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MIRAGE
Insulin receptor signalling cascade

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
Ash-LGRB2-1:SOS1SOS1SHCInsulin:p-6Y-Insulin receptor:SHC1Insulin:p-6Y-Insulin receptorInsulin:p-6Y-Insulin receptor:p-Y427-SHC1ADPATPp-Y427-SHC1GRB2-1:SOS1:p-Y427-SHC1GTPp21 RAS:GTPGDPp21 RAS:GDP
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
Displaying all 6 entries
UniProt ID Protein Name Gene Symbol Pathway Viewer
P01111 GTPase NRas
  • HRAS1
  • NRAS
 view
P01112 GTPase HRas
  • HRAS
  • HRAS1
 view
P06213 Insulin receptor
  • INSR
 view
P29353 SHC-transforming protein 1
  • SHC
  • SHC1
  • SHCA
 view
Q07889 Son of sevenless homolog 1
  • SOS1
 view
Q13322 Growth factor receptor-bound protein 10
  • GRB10
  • GRBIR
  • KIAA0207
 view
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025