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Guidelines
MIRAGE
Insulin receptor

Summary
UniProt ID
P06213
Gene Symbol
  • INSR
Gene ID
3643
Organism
Homo sapiens (human)
GlycoProtDB
GPDB0011401
GlyConnect
GlyGen
P06213
PubChem
P06213
The Human Metabolome Database
HMDBP01521
The O-GlcNAc Database
P06213
Re-Glyco
P06213
Annotation
Keyword
  • 3D-structure
  • ATP-binding
  • Alternative splicing
  • Carbohydrate metabolism
  • Cell membrane
  • Cleavage on pair of basic residues
  • Diabetes mellitus
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Endosome
  • Glycoprotein
  • Lysosome
  • Phosphoprotein
  • Receptor
  • Reference proteome
  • Repeat
  • S-nitrosylation
  • Signal
  • Transmembrane helix
  • Tyrosine-protein kinase
Gene Ontology (GO)
Displaying entries 1 - 10 of 13 in total
GO Term
lysosome
plasma membrane
membrane
axon
receptor complex
late endosome
external side of plasma membrane
insulin receptor complex
caveola
endosome membrane
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MATGGRRGAAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVGNVTVAVPTVAAFPNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPRSNPS
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying entries 1 - 10 of 24 in total
Position Description PubMed ID GlyTouCan ID Source
43 N-linked (GlcNAc...) asparagine
52 N-linked (GlcNAc...) asparagine
105 N-linked (GlcNAc...) asparagine
138 N-linked (GlcNAc...) asparagine
242 N-linked (GlcNAc...) asparagine
282 N-linked (GlcNAc...) asparagine
322 N-linked (GlcNAc...) asparagine
364 N-linked (GlcNAc...) asparagine
424 N-linked (GlcNAc...) asparagine
445 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 6 entries
Pathway Name Organism
IRS activation Homo sapiens
Insulin receptor recycling Homo sapiens
Insulin receptor signalling cascade Homo sapiens
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Homo sapiens
Signal attenuation Homo sapiens
Signaling by Insulin receptor Homo sapiens
Disease
Displaying all 7 entries
DO ID Disease Name Source
DOID:0050470 Donohue syndrome
DOID:0070220 familial hyperinsulinemic hypoglycemia 5
DOID:11714 gestational diabetes
DOID:2526 prostate adenocarcinoma
DOID:3594 choriocarcinoma
DOID:9351 diabetes mellitus
DOID:9352 type 2 diabetes mellitus
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025