The NLRP3 inflammasome

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
ATPATP:P2X7P2X7ATP:P2X7 oligomerK+K+ATP:P2X7 oligomer:PANX1 heptamerPANX1 heptamerNLRP3 elicitor proteinsNLRP3 elicitor proteins:NLRP3NLRP3:SUGT1:HSP90SUGT1:HSP90NLRP3 elicitors:NLRP3NLRP3 elicitors:NLRP3 oligomerHSP90AB1SGT1NLRP3TXNThioredoxin:TXNIPTXNIPROSADFOxidized thioredoxin:TXNIPNLRP3 geneTXNIP:NLRP3NLRP3 elicitor small molecules:NLRP3NLRP3 elicitor small moleculesNLRP3 elicitors:NLRP3 oligomer:ASCASCCASP1NLRP3 elicitors:NLRP3 oligomer:ASC:Procaspase-1PSTPIP1 trimerPSTPIP1 trimer:Pyrin trimerPyrin trimerPyrin trimer:ASC
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025