TRAF3-dependent IRF activation pathway

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
p-T,4S-IRF3:p-T,4S-IRF3IRF3-P dimer:CBP/p300CBP/p300viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3SIKE1TBK1/IKKi:SIKE1dsRNA:RIG-1/MDA5:IPS-1:Ub-TRAF3:TBK1/IKKidsRNA:RIG-1/MDA5:IPS-1:Ub-TRAF3:2xTBK1/IKKidsRNA:RIG-1/MDA5:IPS-1:Ub-TRAF3:2x(TBK1/IKBKE)ATPADPK63polyUb-TRAF3viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVSTBK1, IKBKEdsRNA:RIG-1/MDA5:IPS-1:Ub-TRAF3:TBK1,IKBKE:IRF3,IRF7IRF3,IRF7phosphorylated IRF3/IRF7p-2S-IRF7:p-2S-IRF7p-T,4S-IRF3:p-T,4S-IRF3IRF3-P:IRF7-PIRF3-P:IRF7-P2xp-S477,S479-IRF7IRF3 bound to IFN-beta promoterIFNB1 geneIFNB1
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 4, 2025