Amino acids regulate mTORC1

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
KICSTOR:GATOR1:GATOR2:SESN1,2KICSTOR:GATOR1:GATOR2L-LeuSESN1,2:L-LeuL-ArgCASTOR1:L-Arg:CASTOR2KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR2SAMKICSTOR:GATOR1KICSTOR:GATOR1:BMT2BMT2:AdoMetv-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTPv-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDPPiGTPGDPv-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Argv-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:ArgmTORC1v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDPv-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTPv-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTPKICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR1CASTOR1:L-Arg dimerSLC38A9:L-ArgRHEB:GTP
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying entries 1 - 10 of 19 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
O15342 V-type proton ATPase subunit e 1
  • ATP6H
  • ATP6V0E
  • ATP6V0E1
view
O75140 GATOR1 complex protein DEPDC5
  • DEPDC5
  • KIAA0645
view
P27449 V-type proton ATPase 16 kDa proteolipid subunit c
  • ATP6C
  • ATP6L
  • ATP6V0C
  • ATPL
view
P36543 V-type proton ATPase subunit E 1
  • ATP6E
  • ATP6E2
  • ATP6V1E1
view
P38606 V-type proton ATPase catalytic subunit A
  • ATP6A1
  • ATP6V1A
  • ATP6V1A1
  • VPP2
view
P42345 Serine/threonine-protein kinase mTOR
  • FRAP
  • FRAP1
  • FRAP2
  • MTOR
  • RAFT1
  • RAPT1
view
P55735 Protein SEC13 homolog
  • D3S1231E
  • SEC13
  • SEC13A
  • SEC13L1
  • SEC13R
view
P58004 Sestrin-2
  • Hi95
  • SESN2
  • SEST2
view
Q12980 GATOR1 complex protein NPRL3
  • C16orf35
  • CGTHBA
  • MARE
  • NPRL3
view
Q15382 GTP-binding protein Rheb
  • RHEB
  • RHEB2
view
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025