Response of EIF2AK1 (HRI) to heme deficiency

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
p-T-EIF2AK1:2xferriheme dimerp-T-EIF2AK1:ferriheme dimerFeHMATPp-T,T486,T488-EIF2AK1:ferriheme dimerADPp-S52-EIF2S1:EIF2S2:EIF2S3MPPPP1R15A mRNAGADD34ATF5-201 mRNAATF5DDIT3 geneATF4:DDIT3 geneATF4DDIT3 mRNAATF4:CEBPB,CEBPG,DDIT3:ATF5 geneATF5 geneCEBPB,CEBPG,DDIT3ATF3:ATF4:CEBPB:CHAC1 geneLAPATF3CHAC1 geneCHAC1ATF4:PPP1R15A genePPP1R15A geneGRB10 geneGRB10ATF4 mRNACHOPTRIB3 geneATF4:CEBPB,CEBPG,DDIT3:TRIB3 geneTRIB3CEBPB,CEBPGATF4:CEBPB,CEBPG:ASNS geneASNS geneASNS
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025