Defective homologous recombination repair (HRR) due to BRCA1 loss of function

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
Sister ChromatidPIR51Defective 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:BCDX2 complexPALB2
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying entries 11 - 15 of 15 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
Q92878 DNA repair protein RAD50
  • RAD50
view
Q96B01 RAD51-associated protein 1
  • PIR51
  • RAD51AP1
view
Q99708 DNA endonuclease RBBP8
  • CTIP
  • RBBP8
view
Q99728 BRCA1-associated RING domain protein 1
  • BARD1
view
Q9UQ84 Exonuclease 1
  • EXO1
  • EXOI
  • HEX1
view
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: December 9, 2024