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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
BRCA1-associated RING domain protein 1
Summary
- UniProt ID
- Q99728
- Gene Symbol
-
- BARD1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ANK repeat
- Alternative splicing
- DNA repair
- Isopeptide bond
- Nucleus
- Phosphoprotein
- Reference proteome
- Repeat
- Transferase
- Ubl conjugation
- Ubl conjugation pathway
- Zinc-finger
- Gene Ontology (GO)
| GO Term |
|---|
| nucleus |
| cytoplasm |
| nuclear speck |
| BRCA1-BARD1 complex |
| ubiquitin ligase complex |
| nuclear ubiquitin ligase complex |
| nucleoplasm |
| cytoplasmic ribonucleoprotein granule |
| BRCA1-A complex |
| BRCA1-B complex |
| GO Term |
|---|
| RNA binding |
| metal ion binding |
| kinase binding |
| protein homodimerization activity |
| protein heterodimerization activity |
| ubiquitin-protein transferase activity |
Sequence
MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREPVCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNELSDLKEDKPRKSLFNDAGNKKNSIKMWFSPRSKKVRYVVSKASVQTQPAIKKDASAQQDSYEFVSPSPPADVSERAKKASARSGKKQKKKTLAEINQKWNLEAEKEDGEFDSKEESKQKLVSFCSQPSVISSPQINGEIDLLASGSLTESECFGSLTEVSLPLAEQIESPDTKSRNEVVTPEKVCKNYLTSKKSLPLENNGKRGHHNRLSSPISKRCRTSILSTSGDFVKQTVPSENIPLPECSSPPSCKRKVGGTSGRKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEFDSTVTHVVVPGDAVQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRSRLNREQLLPKLFDGCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTVAYHARPDSDQRFCTQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 103 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Defective DNA double strand break response due to BARD1 loss of function | Homo sapiens |
| Defective DNA double strand break response due to BRCA1 loss of function | Homo sapiens |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function | Homo sapiens |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function | Homo sapiens |
| Defective homologous recombination repair (HRR) due to BRCA1 loss of function | Homo sapiens |
| G2/M DNA damage checkpoint | Homo sapiens |
| HDR through Homologous Recombination (HRR) | Homo sapiens |
| HDR through Single Strand Annealing (SSA) | Homo sapiens |
| Homologous DNA Pairing and Strand Exchange | Homo sapiens |
| Impaired BRCA2 binding to PALB2 | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
