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MIRAGE
Signaling by ALK fusions and activated point mutants

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
ALK fusion proteinsALK fusion protein dimersATPp-7Y ALK fusion protein dimersADPMYH9- and RNF213-ALK fusionsp-7Y MYH9- and RNF213-ALK fusionsALK point mutantsALK point mutant dimersp-7Y ALK point mutant dimersSTAT3STAT3-activating ALK mutants:STAT3STAT3-activating ALK mutantsSTAT3-activating ALK mutants:p-Y STAT3p-Y705,S727-STAT3 dimerSHC1 p46,p52ALK mutant dimers:SHC1SHC-binding ALK mutant dimersALK fusion dimers:p-3Y SHC1ALK fusion dimers:p-3Y SHC1:GRB2GRB2ALK fusion dimers:GRB2GRB2- and PLC gamma-binding ALK fusion protein dimersIRS- and FRS-binding ALK fusion proteinsALK fusions:FRSFRS2,3ALK fusions:p-6Y FRSIRS:ALK fusion proteinsIRS1p-Y IRS1:ALK fusion proteinsPI3K-binding ALK mutantsALK mutants:PIK3R1PIK3R1PIK3CAPI3K-binding ALK fusions:PI3KPIP2PIP3PLC gamma-binding ALK fusion proteins:PLCG1PLC1ALK fusions:p-4Y PLCG1TYK2p-TYK2STAT1, STAT3pY,pS STAT1, STAT3MCL1 geneMCL1MDM2p-MDM2JUNp-S63,S73-JUNADPATPp21 genep21p-T,Y MAPK8,9MAPK8,9p-T,Y MAPK8,9p-T,Y MAPK8,9:TP53 tetramerp-S15,S20-TP53 TetramerUb:p-S15,S20-TP53
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.2.1

Last updated: April 7, 2025