Submissions
GlyTouCan
Glycan Structure Repository
GlyComb
Glycoconjugate Repository
GlycoPOST
Glycomics MS raw data Repository
UniCarb-DR
Glycomics MS Repository for glycan annotations from GlycoWorkbench
LM-GlycoRepo
Repository for lectin-assisted multimodality data
Resources Genes Glycoproteins Lectins Glycolipids Glycans Pathways Diseases Organisms
All Resources
Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Other Information
Release Statistics Download
Tools
SugarDrawer GlycanBuilder Glycan Converters GlycoMaple GlycomeAtlas LM-GlycomeAtlas GALAXY MCAW GlycoSim GRable
Search Tools
Cross Search Glycan Search Publication Search Programmatic Access
Standards Ontologies Notations
Guidelines
MIRAGE
MyD88 cascade initiated on plasma membrane

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
Activated TLR5 or TLR10 homodimerMyD88 complexed with the activated TLR5 or 10 receptorMYD88oligo-MyD88:activated TLR5 or 10IRAK4:oligo-MyD88:activated TLR5 or 10IRAK4ATPp-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10ADPIRAK1 or IRAK2 :p-IRAK4:MyD88 oligomer:activated TLR5 or 10IRAK1, IRAK2IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR5/10p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR5 or 10IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR5/10p-IRAK1:p-IRAK4:oligo-MyD88l:activated TLR5 or 10pp-IRAK1:p-IRAK4:oligo-MyD88 :activated TLR5 or 10 complexhp-IRAK1:activated IRAK4:MyD88oligomer:activated TLR5 or 10hp-IRAK1 or p-IRAK2 : pIRAK4:MyD88:activated TLR5/10TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88 :activated TLR5 or 10TRAF6hp-IRAK1/or p-IRAK2:TRAF6MEKK1:activated TRAF6MEKK1
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".
a simple tooltip
About Release Notes Help Feedback

Click here to visit the beta site.

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

Logo License Policies Site Map

Contact: support@glycosmos.org

This work is licensed under Creative Commons Attribution 4.0 International

GlyCosmos Portal v4.2.1

Last updated: April 7, 2025