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MIRAGE
Regulation of Complement cascade

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
C3AR1C3AR1:C3aC3aC5AR2 ligandsC5AR2:C5AR2 ligandsC5AR2C5aC5AR1:C5aC5AR1C3 convertasesProperdin oligomerC2aCFB(260-764)C3bCell surface:C4bCell surface:C4b:C2aiC3Host cell surfaceCFH:Host cell surfaceCFHCFH, CFHR3Cell surface:FH,FHR3:C3bCell surface:C3bCell surface:CFH, CFHR3:C3bBbCell surface:C3b:BbCFHR dimersCell surface:C3b:CFHR dimersCFICFICFICFI:CFH:C3bCFH:C3bCFI:CFH,FHR3:C3bCFI:CFH,FHR3:iC3bC3CR1:iC3bC3cC3CR1CR1:C3bBb, C4bC2a complexesCR1:C3bCR1:C4bCR2CR2:C3d,C3dg,iC3bC3d, C3dg, iC3bCD19:CD81CR2:C3d,C3dg,iC3b:CD19:CD81CD46:Cell surface:C4bCD46CFI:CD46, CR1:C4b, C3b complexesCD46, CR1:C4b:C3b complexesCD46, CR1C4c, C3fC4d, iC3bC4bC2a, C3bBbCD55:C3 convertase complexesDAFCD55:C3bCD55:C4bC4bC4-binding protein:C4bC4b-binding proteinC4b-binding protein:Factor IC4 binding protein:C4bC2aC4 binding protein:protein Sprotein SC9VTN:C5b:C6:C7:C8:C9VTN:C5b:C6:C7C8VTNC5b:C6:C7H2OC4b with hydrolysed thioesterAntigen:IgG:C1Q:2xActivated C1R:2xActivated C1SAntigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1Activated C1R:SERPING1C1QActivated C1S:SERPING1Antigen:IgGCLUCLU:C5b:C6:C7, C8, C9C5b:C6:C7, C8, C9C3a, C5aC3a-desArg, C5a-desArgiC3bCD46:Cell surface:C3bC4cC4dC5b:C6:C7:C8CD59:C5b-C9CD59Antigen:IgG:C1 with activated C1R, C1SC1InhC5C5aTC5bT
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
Displaying entries 41 - 50 of 54 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
P15529 Membrane cofactor protein
  • CD46
  • MCP
  • MIC10
 view
P17927 Complement receptor type 1
  • C3BR
  • CR1
 view
P20023 Complement receptor type 2
  • C3DR
  • CR2
 view
P20851 C4b-binding protein beta chain
  • C4BPB
 view
P21730 C5a anaphylatoxin chemotactic receptor 1
  • C5AR
  • C5AR1
  • C5R1
 view
P22792 Carboxypeptidase N subunit 2
  • ACBP
  • CPN2
 view
P36980 Complement factor H-related protein 2
  • CFHL2
  • CFHR2
  • FHR2
  • HFL3
 view
Q02985 Complement factor H-related protein 3
  • CFHL3
  • CFHR3
  • FHR3
 view
Q03591 Complement factor H-related protein 1
  • CFHL
  • CFHL1
  • CFHL1P
  • CFHR1
  • CFHR1P
  • FHR1
  • HFL1
  • HFL2
 view
Q16581 C3a anaphylatoxin chemotactic receptor
  • AZ3B
  • C3AR1
  • C3R1
  • HNFAG09
 view
Displaying all 2 entries
GlyCosmos Lectin UniProt ID Lectin Name Pathway Viewer
GL_001413 P0C0L5 Complement C4-B view
GL_002853 P04004 Vitronectin view
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025