Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
p-Y701-STAT1p-Y-STAT1 dimerCa2+Na+Na+K+K+Ca2+Calpain2:Ca2+Calpain2VCLVinculinH2OPiAnnexin A2Annexin A2ITGA5:ITGB1p-S26-ANXA2:ITGA5:ITGB1:Ca2+p-S26-ANXA2:ITGA5:ITGB1:Ca2+:fibronectinFibronectin matrixp-S715-PDE4D5:Zn2+:Mg2+p-S26-ANXA2:p-S715-PDE4D5:ITGA5:ITGB1:fibronectinPPP2R2Ap-S26-ANXA2:PPP2R2A:p-S715-PDE4D5:ITGA5:ITGB1:fibronectinPP2A-subunit Ap-S26-ANXA2:PP2A:p-S715-PDE4D5:ITGA5:ITGB1:fibronectinPPP2CAp-S26-ANXA2:PP2A:PDE4D5:ITGA5:ITGB1:fibronectincAMPAMPp1-YAP1YAP1ABL1ABL1_HUMANATPYAP1_HUMANp-Y407-YAP1p-Y397-PTK2FAKADPIKK complexIKK complexIkB(alpha):NF-kB complexp-S536-RELA:NFKB1(1-433)p-S172-IKBKE homodimerIKBKE:IKBKESTAT12xp-Y-STAT1p-Y701-STAT1:NLRP3 geneNLRP3 gene
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying entries 1 - 10 of 18 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
O14920 Inhibitor of nuclear factor kappa-B kinase subunit beta
  • IKBKB
  • IKKB
view
O15111 Inhibitor of nuclear factor kappa-B kinase subunit alpha
  • CHUK
  • IKKA
  • TCF16
view
P00519 Tyrosine-protein kinase ABL1
  • ABL
  • ABL1
  • JTK7
view
P04632 Calpain small subunit 1
  • CAPN4
  • CAPNS
  • CAPNS1
view
P05106 Integrin beta-3
  • GP3A
  • ITGB3
view
P05556 Integrin beta-1
  • FNRB
  • ITGB1
  • MDF2
  • MSK12
view
P06756 Integrin alpha-V
  • ITGAV
  • MSK8
  • VNRA
  • VTNR
view
P07355 Annexin A2
  • ANX2
  • ANX2L4
  • ANXA2
  • CAL1H
  • LPC2D
view
P08648 Integrin alpha-5
  • FNRA
  • ITGA5
view
P18031 Tyrosine-protein phosphatase non-receptor type 1
  • PTP1B
  • PTPN1
view
a simple tooltip

About Release Notes Help Feedback

Click here to visit the beta site.


International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


Logo License Policies Site Map

Contact: support@glycosmos.org

This work is licensed under Creative Commons Attribution 4.0 International


GlyCosmos Portal v4.2.1

Last updated: April 7, 2025