Oxidative Stress Induced Senescence

Summary
Species
Mus musculus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
ATPADPMAPK8,9,10p-MAPK8,9,10p-MAPK8,9,10p-MKK3,p-MKK6p-MKK3,p-MKK6p38 MAPK:MAPKAPK2,3p-p38 MAPK: MAPKAPK2,3ADPATPp-p38 MAPK:p-MAPKAPK2/3JunP05627FosP01101p-2S-cJUN:p-2S,2T-cFOSp-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53PolyUb-TP53 TetramerUbp-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4p-S37-TP53 TetramerTP53 TetramerCDK4,CDK6CDK4,CDK6:INK4Cdkn2bMAP3K5:TXNTxnMAP3K5ROSMKK3, MKK6Rbbp4PRC2 (EZH2) CoreEzh2Suz12Rbbp7EedFe2+KDM6B:Fe2+KDM6Bp38 MAPK:MAPKAPK5phospho-p38 MAPK: MAPKAPK5phospho-p38 MAPK:p-T-182-MAPKAPK5
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025