HDMs demethylate histones

Summary
Species
Mus musculus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
MeK5-histone H3CH2OHistone H3Me2K5-histone H3MeK37-histone H32OGO2CO2SUCCAMe2K37-histone H3MeK10-histone H3Me2K10-histone H3Me3K10-histone H3Me3K5-histone H3Me2K28-histone H3MeK28-histone H3Me3K28-histone H3MeR3-histone H3Me2aR3-histone H3H4c11H4c11Hist1h4aH4c11
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying all 9 entries
UniProt ID Protein Name Gene Symbol Pathway Viewer
O70546 Lysine-specific demethylase 6A
  • Kdm6a
  • Utx
view
P59997 Lysine-specific demethylase 2A
  • Fbl11
  • Fbxl11
  • Jhdm1a
  • Kdm2a
  • Kiaa1004
view
P62806 Histone H4
  • H4-12
  • H4-53
  • H4c1
  • H4c11
  • H4c12
  • H4c14
  • H4c16
  • H4c2
  • H4c3
  • H4c4
  • H4c6
  • H4c8
  • H4c9
  • H4f16
  • Hist1h4a
  • Hist1h4b
  • Hist1h4c
  • Hist1h4d
  • Hist1h4f
  • Hist1h4h
  • Hist1h4i
  • Hist1h4j
  • Hist1h4k
  • Hist1h4m
  • Hist2h4
  • Hist2h4a
  • Hist4h4
view
Q3U2K5 Lysine-specific demethylase 4D
  • Jhdm3d
  • Jmjd2d
  • Kdm4d
view
Q5NCY0 Lysine-specific demethylase 6B
  • Jmjd3
  • Kdm6b
  • Kiaa0346
view
Q6PCM1 Lysine-specific demethylase 3A
  • Jhdm2a
  • Jmjd1a
  • Kdm3a
  • Kiaa0742
view
Q6ZPY7 Lysine-specific demethylase 3B
  • Jhdm2b
  • Jmjd1b
  • Kdm3b
  • Kiaa1082
view
Q80TJ7 Histone lysine demethylase PHF8
  • Kiaa1111
  • Phf8
view
Q8BM75 AT-rich interactive domain-containing protein 5B
  • Arid5b
  • Desrt
  • Mrf2
view
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025