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MIRAGE
Interleukin-3, Interleukin-5 and GM-CSF signaling

Summary
Species
Mus musculus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
Il5IL5 homodimerIL5 homodimer:IL5RAIl5raIL3RB:JAK2IL5 homodimer:IL5RA:Common beta chain:JAK2High affinity binding complexes of interleukin receptors using the Common beta chainHigh affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2ATPHigh affinity binding complex dimers of cytokine receptors using Bc, activated JAK2ADPSTAT5High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2:p-STAT5p-STAT5High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-BcHigh affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc:SHC1Shc1TECTEC:VAV1Vav1SHP1,SHP2High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-BcHigh affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zetaYwhazp85-containing Class 1A PI3KsHigh affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025