RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

Summary
Species
Mus musculus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
PRMT1RUNX1:CBFB:PRMT1RUNX1:CBFBSAHSAMMeR206,MeR210-RUNX1:CBFB:PRMT1H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2BH3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2BSIN3RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1Hdac1PRMT6RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2-NucleosomeRUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2,H3R2me2a-NucleosomeRUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2-NucleosomeRUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2,H3R2me2a-NucleosomeH3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2BH3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2BH3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2BH3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2BRUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1 gene:H3K4me2-NucleosomeRUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1B gene:H3K4me2,H3R2me2a-NucleosomeH3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2BH3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2BRUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2-NucleosomeRUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2,H3R2me2a-Nucleosome
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying entries 1 - 10 of 21 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
B2RWS6 Histone acetyltransferase p300
  • Ep300
  • P300
view
E9PYH6 Histone-lysine N-methyltransferase SETD1A
  • Setd1a
view
O08550 Histone-lysine N-methyltransferase 2B
  • Kmt2b
  • Mll2
  • Trx2
  • Wbp7
view
O09106 Histone deacetylase 1
  • Hdac1
view
P10853 Histone H2B type 1-F/J/L
  • H2b-f
  • H2b-j
  • H2b-l
  • H2b-n
  • H2bc11
  • H2bc13
  • H2bc15
  • H2bc7
  • Hist1h2bf
  • Hist1h2bj
  • Hist1h2bl
  • Hist1h2bn
view
P10854 Histone H2B type 1-M
  • H2bc14
  • Hist1h2bm
view
P55200 Histone-lysine N-methyltransferase 2A
  • All1
  • Hrx
  • Kmt2a
  • Mll
  • Mll1
view
P62806 Histone H4
  • H4-12
  • H4-53
  • H4c1
  • H4c11
  • H4c12
  • H4c14
  • H4c16
  • H4c2
  • H4c3
  • H4c4
  • H4c6
  • H4c8
  • H4c9
  • H4f16
  • Hist1h4a
  • Hist1h4b
  • Hist1h4c
  • Hist1h4d
  • Hist1h4f
  • Hist1h4h
  • Hist1h4i
  • Hist1h4j
  • Hist1h4k
  • Hist1h4m
  • Hist2h4
  • Hist2h4a
  • Hist4h4
view
Q60520 Paired amphipathic helix protein Sin3a
  • Kiaa4126
  • Sin3a
view
Q64475 Histone H2B type 1-B
  • H2bc3
  • Hist1h2bb
view
a simple tooltip

About Release Notes Help Feedback

Click here to visit the beta site.


International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


Logo License Policies Site Map

Contact: support@glycosmos.org

This work is licensed under Creative Commons Attribution 4.0 International


GlyCosmos Portal v4.2.1

Last updated: April 7, 2025