PKR-mediated signaling

Summary
Species
Mus musculus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
p-EIF2AK2 dimerp-EIF2AK2 dimerTP53 TetramerADPATPp-S392-TP53 tetramerILF2:ILF3ADPATPIlf2Q9Z1X4MAPT-8:MicrotubuleP10637MicrotubuleO55042SNCAQ03963EIF2AK2:CHUK:IKBKB:IKBKGCHUK:IKBKB:IKBKGQ06180PTPN2SPHK1Q8CI15Q8CI15PPP2R5A-specific PP2AActivated PPP2R5A-specific PP2AEIF2AK2 dimer:Host RNA activatorsHost RNA activators of PKRISG15-EIF2AK2 dimerAMPISG15 E3 ligasesUbe2l6PPiISG15:UBCH8:ISG15 E3 ligasep-PRKRA dimerp-PRKRA:EIF2AK2 dimerIlf3ILF3:EIF2AK2 dimerheparinEIF2AK2 dimer:heparinEIF2AK2:NCK1Nck1NPM1:EIF2AK2Npm1P97473p-TARBP2:EIF2AK2DUS2DUS2:EIF2AK2FA Core Complex:HSP70sFA Core Complex:HSP70s:EIF2AK2STAT1,STAT3:EIF2AK2STAT1, STAT3Dnajc3DNAJC3:EIF2AK2ADAR1 dimerADAR1 dimer:EIF2AK2EIF2AK2:p-SPHK1EIF2AK2:PKR inhibitorsPKR inhibitorsO70133DHX9P11440CDK1MAP2K6Phospho MKK6_MOUSE
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
a simple tooltip

About Release Notes Help Feedback

Click here to visit the beta site.


International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


Logo License Policies Site Map

Contact: support@glycosmos.org

This work is licensed under Creative Commons Attribution 4.0 International


GlyCosmos Portal v4.2.1

Last updated: April 7, 2025