Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells

Summary
Species
Mus musculus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
P42225p-Y-STAT1 dimerCa2+Calpain2:Ca2+Calpain2VclVclH2OPiP07356P07356p-S26-ANXA2:ITGA5:ITGB1:Ca2+ITGA5:ITGB1P46938Yap1ABL1P00520ATPP46938P46938PTK2ADPP34152CHUK:IKBKB:IKBKGp-Y187,Y198-CHUK:IKBKB:IKBKGIkB(alpha):NF-kB complexp-S536-RELA:NFKB1(1-433)IKBKE:IKBKEp-S172-IKBKE:p-S172-IKBKEStat12xp-Y-STAT1
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: February 17, 2025