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MIRAGE
Signaling by SCF-KIT

Summary
Species
Rattus norvegicus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
KitlgKitlgKitlgsSCF dimerKITKIT:sSCF dimerKIT:sSCF dimer:KITp-7Y-KIT:sSCF dimer:p-7Y-KITADPATPPI3K:p-KIT:sSCF dimer:p-KITPI3K alphaPIP3PIP2p-VAV1:PIP3Vav1RAC1:GDPRac1:GTPGDPGTPSFKs:p-8Y-KIT:sSCF dimer:p-8Y-KITSFKs:p-KIT complexGRB2:SOS1:p-KIT complexGRB2-1:SOS1SHP2:SFKs:p-KIT:sSCF dimer:p-KITPTPN11p-SHP2:p-KIT complexGrb2GRB2:p-SHP2:p-KIT complexGab2GAB2:GRB2:p-SHP2:p-KIT complexp(Y)-GAB2:GRB2:p-SHP2:p-KIT complexPI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complexp21 RAS:GDPp21 RAS:GTPTyrosine kinasesTyrosine kinases:p-KIT complexAdapter proteinsAdapter proteins:p-KIT complexJAK2:SFKS:p-KIT complexJak2p-JAK2:SFKs:p-KIT complexSTATsp-JAK2:SFKs:p-KIT complex:STATsp-JAK2:SFKs:p-KIT complex:p-STATsp-JAK2:SFKs:p-KIT complex:p-STAT dimersp-STAT dimersPtpruPTPRU:KITtype II KIT binding TKIsKIT:type II TKIstype I KIT binding TKIsKIT:sSCF dimer:KIT:type I KIT binding TKIs:KIT:ripretinibDCC2618
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
Displaying all 4 entries
UniProt ID Protein Name Gene Symbol Pathway Viewer
P05696 Protein kinase C alpha type
  • Pkca
  • Prkca
 view
P21581 Kit ligand
  • Kitl
  • Kitlg
  • Mgf
 view
P50282 Matrix metalloproteinase-9
  • Mmp9
 view
P50339 Chymase
  • Cma1
  • Mcpt3
 view
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025