Downstream TCR signaling

Summary
Species
Rattus norvegicus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
H2OPiPIP3PIP2PI3KPI3K bound to TRATF7F6T0ATPADPPI(3,4)P2PIP3, PI(3,4)P2PDK1:PIP2,PIP3PDPK1DAGPKC-theta (open): DAGPRKCQp-Y90-PKC-theta:DAGActive PKC theta bound to DAGCard11CARMA1 bound to PDK1Activated CARMA1CARMA1 trimerA0A8I6AA96Bcl10 bound to CARMA1Bcl10Phosphorylated Bcl10 bound to CARMA1 and RIP2Bcl10 trimer bound to CARMA1 trimerQ9QYN5MALT1 trimerMALT1 trimer bound to Bcl10 and CARMA1 trimerTRAF6 trimer bound to CBM complexTraf6TAB2/TAK1 complexTAK1/TAB2 complex bound to TRAF6/CBM complexUb-TRAF6 trimer bound to CBM complexCHUK:IKBKB:IKBKGCHUK:p-S177,S181-IKBKB:IKBKG
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 4, 2025