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MIRAGE
Integrin signaling

Summary
Species
Rattus norvegicus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
RAP1:GDPRAP1:GTPGTPGDPD3ZDZ1Rap1-GTP:PIP2:RIAMPIP2Tln1Talin:RIAM complexIntegrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complexIntegrin alphaIIb beta3:p-Y530-SRC:CSKIntegrin binding divalent cationsFocal complexIntegrin alphaIIb beta3 ECM ligandsTalin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK)CSKTalin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC)H2OTalin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC)PiADPATPTalin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC)Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2PTK2Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2Integrin alpha2bbeta3Integrin alpha IIb p(T779)-beta 3Shc1Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHCIntegrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHCQ5M824Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYKSYKTalin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".
a simple tooltip
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025