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MIRAGE
Thrombin signalling through proteinase activated receptors (PARs)

Summary
Species
Rattus norvegicus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
PAR3, 4Thrombin-activated PARsPAR N-teminal fragmentsF2rF2rF2rvorapaxarpro-F2R:vorapaxarThrombin-activated PARs:Gq (inactive)GDPThrombin-activated PAR:Gq (active)GTPThrombin activated PAR:G12/13 (active)Thrombin activated PAR:G12/13 (inactive)ARRB1F2R:ARRB1F2R:ARRB2Arrb2SrcF2R:ARRB1:MAPKs:SRC-1MAPKsF2R:ARRB2:MAPKs:SRC-1F2R:ARRB1:active MAPKs:active SRC-1
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
Displaying all 4 entries
UniProt ID Protein Name Gene Symbol Pathway Viewer
P18292 Prothrombin
  • F2
 view
P26824 Proteinase-activated receptor 1
  • F2r
  • Par1
 view
Q920E0 Proteinase-activated receptor 4
  • F2rl3
  • Par4
 view
Q920E1 Proteinase-activated receptor 3
  • F2rl2
  • Par3
 view
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025