GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **251 - 275** of **557** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism ▲	GlyTouCan ID
HS-GAG biosynthesis	Agrin Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 Exostosin glycosyltransferase 2 Exostosin-1 Glypican 2 Glypican 4 Glypican 5 Glypican-1 Glypican-3 Heparan sulfate 2-O-sulfotransferase 1 Heparan-sulfate 6-O-sulfotransferase Heparan-sulfate 6-O-sulfotransferase Solute carrier family 35 member D2 Sulfotransferase Sulfotransferase Sulfotransferase Sulfotransferase Sulfotransferase Sulfotransferase Syndecan-1 Syndecan-2 Syndecan [heparan sulfate]-glucosamine N-sulfotransferase [heparan sulfate]-glucosamine N-sulfotransferase	A0A3Q1LS54 A0A3Q1LTY7 A0A3Q1LZ29 A0A3Q1M8D2 A0A3S5ZPA0 A5D7I4 A8E4L2 E1B729 E1BCG5 E1BJP5 E1BKJ2 E1BKQ1 E1BKS1 E1BM02 E1BNJ7 E1BP03 F1MCX1 F1MMN3 F1MZX8 Q08DZ5 Q0VCB5 Q0VD21 Q3ZBZ6 Q58DD4	AGRN EXT1 EXT2 GPC1 GPC2 GPC3 GPC4 GPC5 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST5 HS3ST6 HS6ST2 HS6ST3 NDST1 NDST2 NDST4 SDC1 SDC2 SDC4 SLC35D2	Bos taurus (cattle)
Trafficking and processing of endosomal TLR	Cathepsin B Cathepsin K Cathepsin S Endoplasmin Legumain Procathepsin L Protein canopy homolog 3 Toll like receptor 3 Toll like receptor 7 Toll-like receptor 9 Unc-93 homolog B1, TLR signaling regulator	A0A140T8D4 A0A3Q1MK24 A0A3S5ZPK8 A5H631 E1BBH4 P07688 P25326 P25975 Q0P5N1 Q5E968 Q95M18	CNPY3 CTSB CTSK CTSL CTSL1 CTSS GRP94 HSP90B1 HSPC4 LGMN TLR3 TLR7 TLR9 TRA1 UNC93B1	Bos taurus (cattle)
WNT ligand biogenesis and trafficking	Protein Wnt-2 Protein Wnt Protein Wnt Protein Wnt Protein Wnt Protein Wnt Protein Wnt Protein Wnt Protein Wnt Protein Wnt Protein Wnt Protein Wnt Protein Wnt Protein Wnt Protein Wnt Protein Wnt Protein Wnt Sorting nexin-3 Transmembrane emp24 domain-containing protein 5 Vacuolar protein sorting-associated protein 26A Vacuolar protein sorting-associated protein 29 Vacuolar protein sorting-associated protein 35 Wnt ligand secretion mediator	A0A140T847 A0A3Q1LTW2 A0A3Q1M1A0 A0A3Q1MGH5 A0A3Q1MJR6 A0A3Q1MQ82 A4D7S0 A6H6X8 E1BDG5 E1BEN9 E1BKL2 F1MEW8 F1MHG3 F1MK64 F1MN70 F1N4C0 F1N5R1 F1N6L8 Q0VD53 Q1RMH8 Q2HJG5 Q2KJ84 Q3T0M0	SNX3 TMED5 VPS26A VPS29 VPS35 WLS WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT6 WNT7A WNT7B WNT8A WNT8B WNT9B	Bos taurus (cattle)
Metabolism of Angiotensinogen to Angiotensins	Aminopeptidase Angiotensin-converting enzyme Angiotensinogen Carboxylic ester hydrolase Carboxypeptidase A3 Carboxypeptidase B2 Carboxypeptidase B Cathepsin D Cathepsin Z Neprilysin Peptidase S1 domain-containing protein Peptidase S1 domain-containing protein Peptidase S1 domain-containing protein Peptidase S1 domain-containing protein Renin receptor renin	A0A3Q1LTF9 A0A3Q1MQJ1 A0A452DJE0 E1B8U1 E1BAD2 E1BIP7 E1BK06 E1BPL8 F1MEM5 F1MMR6 F1MZL4 P00732 P01017 P05689 P81134 Q2KIG3	ACE2 AGT ATP6AP2 ATP6IP2 CES1 CPA3 CPB CPB1 CPB2 CTSD CTSZ ENPEP LOC100139881 LOC509956 LOC540321 LOC617313 MME REN SERPINA8	Bos taurus (cattle)
Interleukin-7 signaling	Bromodomain and WD repeat domain containing 1 Cytokine receptor common subunit gamma Histone H3.1 Histone H3.2 Insulin receptor substrate 1 Insulin receptor substrate 2 Interleukin-7 receptor subunit alpha Interleukin-7 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphoinositide-3-kinase regulatory subunit 3 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription Signal transducer and activator of transcription Transcription activator BRG1 Tyrosine-protein kinase Tyrosine-protein kinase	A0A140T878 A7Z019 E1BEL4 E1BPM3 F1MDQ5 F1MJE0 F1MTQ0 F1MX38 F1MYE0 F1N0D6 P23726 P23727 P26895 P68432 P84227 Q95115 Q95118	BAF190A BRG1 BRWD1 IL2RG IL7 IL7R IRS1 IRS2 JAK1 JAK3 MGF PIK3R1 PIK3R2 PIK3R3 SMARCA4 SNF2B SNF2L4 STAT3 STAT5A STAT5B	Bos taurus (cattle)
Cross-presentation of particulate exogenous antigens (phagosomes)	Cytochrome b-245 heavy chain Cytochrome b-245 light chain Integrin beta Integrin subunit alpha V Neutrophil cytosolic factor 1 Neutrophil cytosolic factor 2 Neutrophil cytosolic factor 4 Platelet glycoprotein 4	A0A3Q1MKI4 A0A3Q1MTW8 A0A3Q1MXS2 A0A452DHY1 O46521 O46522 P26201 Q8SQB9	CD36 CYBA CYBB ITGAV ITGB5 NCF1 NCF2 NCF4 PAS4	Bos taurus (cattle)
Fatty acyl-CoA biosynthesis	3-oxoacyl-[acyl-carrier-protein] reductase ATP-citrate synthase Acetyl-CoA carboxylase 1 FabG-like protein Fatty acid synthase Long-chain-fatty-acid--CoA ligase Lysosomal thioesterase PPT2 MORC family CW-type zinc finger 2 Palmitoyl-protein thioesterase 1 Stearoyl-CoA desaturase 5 Stearoyl-CoA desaturase	A0A3Q1M4C7 A0A3Q1MUW1 A4IFA7 E1BGP4 F1MSA1 F1N647 Q1JQA0 Q2KIA4 Q32PF2 Q32S21 Q9TT94	ACACA ACLY CBR4 FABGL FASN HKE6 HSD17B8 MORC2 PPT1 PPT2 SCD SCD5 SLC27A2	Bos taurus (cattle)
UCH proteinases	26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 ACTL6A protein ASXL transcriptional regulator 1 ASXL transcriptional regulator 2 Actin, cytoplasmic 1 Actin-related protein 5 Actin-related protein 8 BRCA1 associated RING domain 1 Chromatin-remodeling ATPase INO80 Forkhead box K1 Forkhead box K2 Histone H2A type 1 Histone H2A Histone H2A Histone H2A Histone H2A Histone H2A Histone H2A Host cell factor C1 INO80 complex subunit B INO80 complex subunit C INO80 complex subunit D INO80 complex subunit E Lysine demethylase 1B Methyl-CpG binding domain protein 5 Methyl-CpG binding domain protein 6 Microspherule protein 1 NEDD8 Nuclear factor related to kappaB binding protein Polyubiquitin-B Polyubiquitin-C Proteasomal ubiquitin receptor ADRM1 Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14 Proteasome 26S subunit, ATPase 3 Proteasome 26S subunit, ATPase 6 Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha type Proteasome subunit beta type-10 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Proteasome subunit beta Proteasome subunit beta RuvB-like helicase TCF3 fusion partner homolog UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit Ubiquitin carboxyl-terminal hydrolase isozyme L1 Ubiquitin carboxyl-terminal hydrolase isozyme L3 Ubiquitin carboxyl-terminal hydrolase isozyme L5 Ubiquitin carboxyl-terminal hydrolase Ubiquitin-like protease family profile domain-containing protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein YY1 protein	A0A0A0MP93 A0A3Q1LGR3 A0A3Q1LKK5 A0A3Q1LL22 A0A3Q1MDK7 A0A3Q1MF62 A0A3Q1N8M5 A0A3Q1NAR0 A0A3S5ZPK0 A0A452DI44 A0A452DIY4 A1L5A6 A4IFJ8 A4IFU5 A5D7T6 A7MBA2 A7MBG8 A7YWI5 E1BBH8 E1BBU9 E1BD83 E1BGF3 E1BH22 E1BKK7 F1MAV4 F1MBI1 F1MLV1 F1MP14 F1MPR9 F1MW83 F1MWE0 F1MXE4 F1MYH8 F1N6Z0 F2Z4J1 F6QIL4 G3MYU1 G3N1W1 G5E589 P0C0S9 P0CG53 P0CH28 P23356 P33672 P56701 P60712 P61282 P62194 P62992 P63048 Q08E44 Q17QH7 Q17QP9 Q1LZF2 Q29RS4 Q2KI42 Q2KJ25 Q2KJ46 Q2KJE7 Q2TBG8 Q2YDE4 Q32KL2 Q3MHN0 Q3SX30 Q3SZ19 Q3SZC2 Q3T030 Q3T0T1 Q3T0X5 Q3T0Y5 Q3T108 Q3T112 Q3ZBD0 Q3ZBG0 Q3ZCK9 Q58DU5 Q5E964 Q5E987 Q5E9F9 Q5E9G3 Q5E9K0 Q9XSJ0	ACTB ACTL6A ACTR5 ACTR8 ADRM1 ARP8 ASXL1 ASXL2 BAP1 BARD1 CCDC95 FOXK1 FOXK2 H2AC10 H2AC18 H2AC21 H2AC25 H2AC6 H2AW HCFC1 HIST3H2A INO80 INO80B INO80C INO80D INO80E KDM1B LOC614881 MBD5 MBD6 MCRS1 NEDD8 NFRKB OGT PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RPS27A RUVBL1 SENP8 SUG1 TFPT TRAP2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UCH37 UCHL1 UCHL3 UCHL5 YY1	Bos taurus (cattle)
Negative regulation of FGFR1 signaling	E3 ubiquitin-protein ligase CBL Fibroblast growth factor 1 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Growth factor receptor-bound protein 2 Klotho Mitogen-activated protein kinase 1 Mitogen-activated protein kinase Polyubiquitin-B Polyubiquitin-C Tyrosine-protein phosphatase non-receptor type Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A0A3Q1LN00 A0A3Q1LUE0 A0A3Q1NAV6 A0MTF4 D8KXU9 E1B7I9 E1B8P9 E1BAI2 E1BGY3 E1BHC1 E1BJU2 E1BP37 F1N339 F1N6G8 G3MXR4 G3XGD3 P03968 P03969 P0CG53 P0CH28 P46196 P62992 P63048 Q3T0F9	AFGF CBL ERK2 FGF1 FGF10 FGF17 FGF2 FGF20 FGF23 FGF3 FGF4 FGF4A FGF5 FGF5C FGF6 FGF7B FGF8 FGF9 FGFA FGFR1 FRS2 Fgf4 GRB2 HBGF-1 KL MAPK1 MAPK3 PRKM1 PTPN11 RPS27A UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Bos taurus (cattle)
Orexin and neuropeptides FF and QRFP bind to their respective receptors	Neuropeptide FF receptor 1 Neuropeptide FF receptor 2 Orexin receptor type 2 Orexin/Hypocretin receptor type 1 Pro-FMRFamide-related neuropeptide FF Pyroglutamylated RFamide peptide receptor Pyroglutamylated RFamide peptide	E1BHL6 F1MG23 F1MXG2 F1MXG7 F1N1Y7 Q0GBZ5 Q9TUX7	HCRTR1 HCRTR2 NPFF NPFFR1 NPFFR2 QRFP QRFPR	Bos taurus (cattle)
Sensory perception of salty taste	Amiloride-sensitive sodium channel subunit alpha Amiloride-sensitive sodium channel subunit beta Amiloride-sensitive sodium channel subunit gamma Sodium channel epithelial 1 subunit delta	A5D7U4 F1MJW3 F1MY57 P55270	SCNN1A SCNN1B SCNN1D SCNN1G	Bos taurus (cattle)
TGF-beta receptor signaling activates SMADs	E3 ubiquitin-protein ligase CBL Integrin beta-6 Integrin beta Integrin beta Integrin beta Integrin beta Integrin subunit alpha V Latent transforming growth factor beta binding protein 1 Latent transforming growth factor beta binding protein 2 Latent transforming growth factor beta binding protein 3 Latent transforming growth factor beta binding protein 4 Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog NEDD8-conjugating enzyme Ubc12 NEDD8 Peptidyl-prolyl cis-trans isomerase FKBP1A Serine/threonine-protein kinase receptor TGF-beta receptor type-1 Transforming growth factor beta receptor 3 Transforming growth factor beta-1 proprotein Transforming growth factor beta-2 proprotein Transforming growth factor beta Zinc finger FYVE domain-containing protein furin	A0A140T8D2 A0A3Q1LJU9 A0A3Q1LN00 A0A3Q1MXS2 A0A3Q1N449 A3KN22 A6QP91 B0JYL0 B0JYR0 E1B9H5 E1BE92 F1MF86 F1MKY4 F1MTN1 F1MUZ3 F1MVW3 F1N444 G3MZT8 G3MZV8 O46680 P18203 P21214 P61282 Q8SQB8 Q8SQB9	CBL FKBP1 FKBP1A FURIN ITGAV ITGB1 ITGB3 ITGB5 ITGB6 ITGB8 LTBP1 LTBP2 LTBP3 LTBP4 NEDD8 SMAD2 SMAD3 SMAD4 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3 UBC12 UBE2M ZFYVE9	Bos taurus (cattle)
Formation of the beta-catenin:TCF transactivating complex	ASH2 like, histone lysine methyltransferase complex subunit BCL9 like BCL9 transcription coactivator Catenin beta-1 Cell division cycle 73 Histone H2A.J Histone H2A.V Histone H2A/H2B/H3 domain-containing protein Histone H2A/H2B/H3 domain-containing protein Histone H2A/H2B/H3 domain-containing protein Histone H2A Histone H2A Histone H2A Histone H2A Histone H2B type 1 Histone H2B Histone H2B Histone H2B Histone H2B Histone H2B Histone H2B Histone H2B Histone H3.1 Histone H3.2 Histone H3.3 Histone H3 Histone H4 Histone acetyltransferase Histone deacetylase 1 Lymphoid enhancer binding factor 1 Menin Pygopus family PHD finger 1 RBBP5 protein RNA polymerase-associated protein LEO1 RuvB-like helicase TLE family member 1, transcriptional corepressor TLE family member 2, transcriptional corepressor TLE family member 3, transcriptional corepressor TLE family member 4, transcriptional corepressor Telomerase reverse transcriptase Transcription activator BRG1 Transcription factor 7 like 1 Transcription factor 7 like 2 Transcription factor 7 Transformation/transcription domain associated protein histone acetyltransferase histone acetyltransferase	A0A3Q1LJY1 A0A3Q1LTE2 A0A3Q1LW99 A0A3Q1M3K5 A0A3Q1M6V2 A0A3Q1MAN6 A0A3Q1MBN5 A0A3Q1MF62 A0A3Q1MG64 A0A3Q1MIR9 A0A3Q1MZ99 A4FUE3 A7MBG8 A7Z019 E1B8D6 E1B8G9 E1BEP4 E1BH22 E1BHL3 E1BKJ5 E1BPF3 E1BPQ8 F1MD32 F1MHP8 F1MJS2 F1ML22 F1MUU9 F1MXC3 F2Z4F9 F2Z4J1 G3MWX6 G3MYB1 G3N0M9 G5E6I9 P62803 P62808 P68432 P84227 Q0P5I0 Q0VBX4 Q0VCX4 Q2KII5 Q32LA7 Q32PJ8 Q32S29 Q3ZBX9 Q5E9F8	ASH2L BAF190A BCL9 BCL9L BRG1 CDC73 CREBBP CTNNB1 EP300 H2AC12 H2AC18 H2AC21 H2AC6 H2AJ H2AV H2AZ2 H2B H2BC26 H2BC5 H3-3A H3-3B H3F3A H3F3B HDAC1 HIST1H2BI KAT5 LEF1 LEO1 LOC100297725 LOC528006 MEN1 PYGO1 RBBP5 RUVBL1 SMARCA4 SNF2B SNF2L4 TCF7 TCF7L1 TCF7L2 TERT TLE1 TLE2 TLE3 TLE4 TRRAP	Bos taurus (cattle)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	AMICA1 protein B-cell receptor CD22 Beta-2-microglobulin C-type lectin domain family 4 member G C5H12ORF53 protein CD19 molecule CD200 molecule CD200 molecule CD300 molecule like family member b CD300a molecule CD40 ligand CD40 ligand CD8 subunit beta CD81 antigen CD99 molecule CMRF35-like molecule 9 CRTAM protein Cell surface glycoprotein CD200 receptor 1 Collectin-12 Complement C3 Coxsackievirus and adenovirus receptor homolog Fc fragment of IgG receptor Ia Hematopoietic cell signal transducer Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Immunoglobulin subtype domain-containing protein Immunoglobulin subtype domain-containing protein Integrin alpha-L Integrin beta-2 Integrin beta Integrin beta Integrin subunit alpha 4 Intercellular adhesion molecule 1 Intercellular adhesion molecule 3 Intercellular adhesion molecule 5 Intercellular adhesion molecule N-terminal domain-containing protein Interferon induced transmembrane protein 3 (1-8U) Interferon induced transmembrane protein 3 Interferon-induced transmembrane protein 1 Interferon-induced transmembrane protein 1 Interferon-induced transmembrane protein 3 KLRF1 protein Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A Killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1 MHC class I-like antigen recognition-like domain-containing protein MHC class I-like antigen recognition-like domain-containing protein MHC class I-like antigen recognition-like domain-containing protein MHC class I-like antigen recognition-like domain-containing protein MHC class I-like antigen recognition-like domain-containing protein MHC class I-like antigen recognition-like domain-containing protein MHC class I-like antigen recognition-like domain-containing protein MHC class I-like antigen recognition-like domain-containing protein MHC class I-like antigen recognition-like domain-containing protein Major histocompatibility class I related protein NKG2-D type II integral membrane protein NPDC1 protein Natural cytotoxicity triggering receptor 3 Natural killer cell cytotoxicity receptor 3 ligand 1 Nectin cell adhesion molecule 2 Osteoclast associated Ig-like receptor Paired immunoglobin like type 2 receptor alpha SLAM family member 6 SLAM family member 7 Sialic acid binding Ig like lectin 10 Sialic acid binding Ig like lectin 1 T-cell surface glycoprotein CD1b-1-like T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD3 zeta chain T-cell surface glycoprotein CD8 alpha chain TRAV29-1*01 Triggering receptor expressed on myeloid cells 1 Triggering receptor expressed on myeloid cells like 1 Triggering receptor expressed on myeloid cells like 2 Tumor necrosis factor receptor superfamily member 5 UL16 binding protein 21 UL16-binding protein 17 ULBP13 Uncharacterized protein Uncharacterized protein Uncharacterized protein VCAM1 protein	A0A140T8D2 A0A3Q1LRW6 A0A3Q1LSQ1 A0A3Q1LT76 A0A3Q1M205 A0A3Q1M3D2 A0A3Q1M8C4 A0A3Q1MA43 A0A3Q1MAE8 A0A3Q1MD45 A0A3Q1ME80 A0A3Q1MKD6 A0A3Q1ML46 A0A3Q1MLJ0 A0A3Q1MNF5 A0A3Q1MQ30 A0A3Q1MRJ9 A0A3Q1MT21 A0A3Q1MT87 A0A3Q1MTX6 A0A3Q1NI55 A0A3Q1NLL2 A0A3Q1NN33 A0A3S5ZP99 A0A452DIT3 A4IFJ4 A5D7B2 A5D7V5 A5PJG8 A6H6Y6 A6QP79 A6QPH6 A6QQ36 A7MAZ7 A7MBB0 A7YW30 A7YWT5 E1B7F4 E1B8E5 E1B8Y2 E1BFU3 E1BGL8 E1BHM4 E1BI37 E1BI56 E1BLR0 F1MEF6 F1MG16 F1MGI2 F1MI38 F1MI53 F1MIE5 F1MJX3 F1MLN1 F1MNL2 F1MQD8 F1MQF0 F1MQX6 F1MRK8 F1MST2 F1MZE6 F1MZQ5 F1N4Y5 F1N586 F6RKH9 F7VJN2 G3MZR7 G3N2K2 G3X797 G3X7K3 G5E542 G5E587 G5E5B4 G5E5F5 G5E5G6 G5E5L3 G5E5L8 G5E5X5 G5E6I1 G8JL01 P01888 P32592 P61625 Q09YM2 Q09YM5 Q0VCU4 Q1XF11 Q28072 Q28073 Q28203 Q2UVX4 Q32LF2 Q3ZBV6 Q3ZC60 Q3ZCD0 Q8SPQ5 Q8WMV3	AMICA1 B2M BOLA BOLA-NC1 C3 C5H12ORF53 CAR CD18 CD19 CD1B5 CD200 CD200R CD200R1 CD22 CD247 CD300A CD300LB CD300LF CD300LG CD3D CD3E CD3G CD40 CD40LG CD81 CD8A CD8B CD99 CLEC4G CLM9 CLP1 COLEC12 CRTAM CXADR DAP10 FCGR1A HCST ICAM1 ICAM3 ICAM5 IFITM3 ITGA4 ITGAL ITGB1 ITGB2 ITGB7 JAML KIR2DL1 KIR2DL5A KIR2DS1 KIR3DL2 KIR3DS1 KLRF1 KLRK1 LOC100138951 LOC100850276 LOC100852061 LOC112443864 LOC112444847 LOC512286 LOC515418 LOC526163 LOC534578 LOC613699 LOC616254 LOC618268 LOC618463 LOC777594 LOC783508 MIC2 NCR3 NCR3LG1 NECTIN2 NPDC1 OSCAR PIANP PILRA SIGLEC1 SIGLEC10 SLAMF6 SLAMF7 TNFRSF5 TRAV29-1 TREM1 TREML1 TREML2 ULBP13 ULBP17 ULBP21 VCAM1	Bos taurus (cattle)
SCF(Skp2)-mediated degradation of p27/p21	26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 CDKN1A protein Cullin 1 Cyclin E1 Cyclin-A1 Cyclin-A2 Cyclin-dependent kinase 2 Cyclin-dependent kinase 4 Cyclin-dependent kinase inhibitor 1B Cyclin-dependent kinases regulatory subunit 1 G1/S-specific cyclin-D1 G1/S-specific cyclin-E2 Polyubiquitin-B Polyubiquitin-C Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14 Proteasome 26S subunit, ATPase 3 Proteasome 26S subunit, ATPase 6 Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-10 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Proteasome subunit beta Proteasome subunit beta S-phase kinase-associated protein 1 SKP2 protein Tyrosine-protein kinase Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A0A452DI44 A0A452DIV3 A5PKM2 A6QLS3 A7MB09 A7MBA2 E1B9U2 E1BNA8 F1MBI1 F1MLV1 F1MVR8 F1MWE0 F1MXE4 F1MYD0 F1MYH8 F1N6Z0 G5E589 G8JKW1 P0CG53 P0CH28 P33672 P56701 P62194 P62992 P63048 Q0P5A5 Q17QP9 Q2KI42 Q2KJ25 Q2KJ46 Q2KJE7 Q2YDE4 Q32KL2 Q32KY4 Q3MHN0 Q3SX30 Q3SZ19 Q3SZC2 Q3T030 Q3T0T1 Q3T0X5 Q3T0Y5 Q3T108 Q3T112 Q3ZBD0 Q3ZBG0 Q3ZCF3 Q3ZCK9 Q58DU5 Q5E964 Q5E987 Q5E9F9 Q5E9G3 Q5E9K0 Q5E9K7 Q5E9Y0	CCNA1 CCNA2 CCND1 CCNE1 CCNE2 CDK2 CDK4 CDKN1A CDKN1B CDKN2 CKS1 CKS1B CUL1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSMF1 PTK6 RPS27A SKP1 SKP1A SKP2 SUG1 TRAP2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Bos taurus (cattle)
Regulation of IFNG signaling	Interferon gamma receptor 1 Interferon gamma receptor 2 Interferon gamma Protein inhibitor of activated STAT 1 Rad60/SUMO-like domain-containing protein Rad60/SUMO-like domain-containing protein Signal transducer and activator of transcription Suppressor of cytokine signaling 1 Suppressor of cytokine signaling 3 Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type	A0A3Q1LLQ7 A0A3Q1M2W5 A0A3Q1ME65 A0A3Q1ML58 A0A3Q1MPM2 E1BCP6 F1MSN0 F1MXR5 F1N0D6 G3MZL6 P07353 Q9BEG9	IFNG IFNGR1 IFNGR2 JAK1 JAK2 PIAS1 PTPN2 SOCS1 SOCS3 STAT1	Bos taurus (cattle)
Pentose phosphate pathway	6-phosphogluconate dehydrogenase, decarboxylating 6-phosphogluconolactonase Deoxyribose-phosphate aldolase Glucose-6-phosphate 1-dehydrogenase Phosphoglucomutase 2 Ribokinase Ribulose-phosphate 3-epimerase Sedoheptulokinase Transaldolase Transketolase ribose-5-phosphate isomerase	A0A3Q1MM55 A0A3S5ZPM3 A0A3S5ZPP1 A5D7P1 A7Z014 E1BJH7 F1MM83 F6QEU6 G5E534 G5E5C8 Q3T0V9	DERA G6PD PGD PGLS PGM2 RBKS RPE RPIA SHPK TALDO1 TKT	Bos taurus (cattle)	G31080DL
Interleukin-15 signaling	Cytokine receptor common subunit gamma Growth factor receptor-bound protein 2 Interleukin-15 SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1 SOS Ras/Rho guanine nucleotide exchange factor 2 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription Signal transducer and activator of transcription Tyrosine-protein kinase Tyrosine-protein kinase	A0A140T878 E1BEL4 F1MX38 F1N0D6 F1N1J9 F1N7C3 Q0IIE2 Q28028 Q3T0F9 Q95115 Q95118	GRB2 IL15 IL2RG JAK1 JAK3 L2HGDH MGF SHC1 SOS1 SOS2 STAT3 STAT5A STAT5B	Bos taurus (cattle)
Interconversion of nucleotide di- and triphosphates	Adenylate kinase 2, mitochondrial Adenylate kinase 4, mitochondrial Adenylate kinase 5 Adenylate kinase 7 Adenylate kinase 8 Adenylate kinase 9 Adenylate kinase isoenzyme 1 Adenylate kinase isoenzyme 6 CTP synthase 2 CTP synthase DCTD protein Deoxyuridine 5'-triphosphate nucleotidohydrolase Glutathione reductase Guanylate kinase NAD(+) diphosphatase Nucleoside diphosphate kinase A 2 Nucleoside diphosphate kinase B Nucleoside diphosphate kinase Ribonucleoside-diphosphate reductase subunit M2 Ribonucleoside-diphosphate reductase Ribonucleotide reductase regulatory TP53 inducible subunit M2B Thioredoxin reductase 1, cytoplasmic Thioredoxin Thymidylate synthase UMP-CMP kinase nucleoside-diphosphate kinase	A0A3Q1MKM8 A0A3Q1MT44 A0A452DIX8 A0JNE9 A5PJA1 A5PK70 A6QQC3 E1B7Q2 E1BFQ8 E1BI58 E1BKZ1 E1BLG0 F1MSF1 F1MUF5 F1MY63 F1N6T4 O62768 O97680 P00570 P08166 P46195 P52175 Q0VCP1 Q1RMI9 Q1RMS2 Q3T0Q4	AK1 AK2 AK3L1 AK4 AK5 AK6 AK7 AK8 AK9 CINAP CMPK CMPK1 CTPS CTPS1 CTPS2 DCTD DUT GSR GUK GUK1 NME1-2 NME2 NME3 NME4 NUDT13 RRM1 RRM2 RRM2B TXN TXNRD1 TYMS	Bos taurus (cattle)
Elastic fibre formation	Elastin Fibrillin 2 Fibrillin-1 Fibulin-5 Integrin beta-6 Integrin beta Integrin beta Integrin subunit alpha V Lysyl oxidase homolog 2 Lysyl oxidase homolog Lysyl oxidase homolog Microfibril associated protein 5 furin protein-lysine 6-oxidase protein-lysine 6-oxidase	A0A140T828 A0A140T8D2 A0A3Q1M1V6 A0A3Q1MEV3 A0A3Q1MXS2 A0JNB6 A5D7S7 A6H737 B0JYR0 E1BFC8 F1MTN1 F1MTZ4 G1K200 P98133 Q8SQB8	ELN FBLN5 FBN1 FBN2 FURIN ITGAV ITGB1 ITGB3 ITGB6 LOX LOXL1 LOXL2 LOXL3 LOXL4 MFAP5	Bos taurus (cattle)
Collagen biosynthesis and modifying enzymes	A disintegrin and metalloproteinase with thrombospondin motifs 2 ADAM metallopeptidase with thrombospondin type 1 motif 14 ADAM metallopeptidase with thrombospondin type 1 motif 3 COL8A1 protein Collagen alpha-1(I) chain Collagen alpha-1(II) chain Collagen alpha-1(IV) chain Collagen alpha-2(I) chain Collagen beta(1-O)galactosyltransferase 2 Collagen type III alpha 1 chain Collagen type IV alpha 3 chain Collagen type IV alpha 5 chain Collagen type IV alpha 6 chain Collagen type V alpha 1 chain Collagen type V alpha 3 chain Collagen type VI alpha 1 chain Collagen type VI alpha 2 chain Collagen type VI alpha 3 chain Collagen type VI alpha 5 chain Collagen type VI alpha 6 chain Collagen type VIII alpha 2 chain Collagen type X alpha 1 chain Collagen type XI alpha 1 chain Collagen type XI alpha 2 chain Collagen type XII alpha 1 chain Collagen type XIII alpha 1 chain Collagen type XIV alpha 1 chain Collagen type XVI alpha 1 chain Collagen type XVII alpha 1 chain Collagen type XVIII alpha 1 chain Collagen type XX alpha 1 chain Collagen type XXIII alpha 1 chain Collagen type XXVI alpha 1 chain Collagen type XXVII alpha 1 chain Collagen type XXVIII alpha 1 chain Metalloendopeptidase Metalloendopeptidase Metalloendopeptidase Procollagen C-endopeptidase enhancer 2 Procollagen C-endopeptidase enhancer Procollagen galactosyltransferase 1 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 Prolyl 4-hydroxylase subunit alpha-1 Prolyl 4-hydroxylase subunit alpha-3 Protein disulfide-isomerase Serpin H1 procollagen-lysine 5-dioxygenase procollagen-lysine 5-dioxygenase procollagen-proline 3-dioxygenase procollagen-proline 3-dioxygenase procollagen-proline 4-dioxygenase	A0A3Q1LXW3 A0A3Q1LYA4 A0A3Q1M646 A0A3Q1M970 A0A3Q1NK51 A5PK45 A6QLY3 A7E303 A7MB83 E1BA17 E1BB91 E1BBC6 E1BC50 E1BEV7 E1BFV4 E1BI98 E1BKJ9 F1MD40 F1MET0 F1MF35 F1MJQ6 F1MJR6 F1MKG2 F1MKP1 F1MRP6 F1MSJ7 F1MZ30 F1MZU6 F1N0K0 F1N0V8 F1N0X6 F1N401 F1N6W9 F6Q9Q9 F6RND5 G3MXK9 G3MZI7 G3N021 G3N2F2 G8JKV7 P02453 P02459 P02465 P79331 Q08E14 Q1RMU3 Q2HJB6 Q2KJH6 Q75UG4 Q7SIB2 W0SK50	ADAMTS14 ADAMTS2 ADAMTS3 BMP1 COL10A1 COL11A1 COL11A2 COL12A1 COL13A1 COL14A1 COL16A1 COL17A1 COL18A1 COL1A1 COL1A2 COL20A1 COL23A1 COL26A1 COL27A1 COL28A1 COL2A1 COL3A1 COL4A1 COL4A3 COL4A5 COL4A6 COL5A1 COL5A3 COL6A1 COL6A2 COL6A3 COL6A5 COL6A6 COL8A1 COL8A2 COLGALT1 COLGALT2 GLT25D1 LEPREL1 NPI P3H2 P3H3 P4HA1 P4HA2 P4HA3 P4HB PCOLCE PCOLCE2 PLOD1 PLOD2 PLOD3 SERPINH1 TLL1 TLL2	Bos taurus (cattle)
Phase I - Functionalization of compounds	Aldehyde dehydrogenase Alpha/beta hydrolase fold-3 domain-containing protein Amine oxidase [copper-containing] 3 Amine oxidase Amine oxidase Amine oxidase Aryl hydrocarbon receptor nuclear translocator 2 Aryl hydrocarbon receptor nuclear translocator Aryl hydrocarbon receptor Arylacetamide deacetylase Biphenyl hydrolase like CYB5B protein Carbonyl reductase (NADPH) Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxymethylenebutenolidase homolog Cytochrome P450 3A Cytochrome P450 3A Cytochrome P450 3A Cytochrome P450 3A Cytochrome P450 family 2 subfamily B member 6 Epoxide hydrolase Mitochondrial amidoxime reducing component 1 Mitochondrial amidoxime reducing component 2 NAD(P)H dehydrogenase, quinone 2 NADH-cytochrome b5 reductase 3 Primary amine oxidase, liver isozyme	A0A3Q1LGS8 A0A3Q1LKX3 A0A3Q1LZ03 A0A3Q1M7J3 A0A3Q1MQJ1 A0A3Q1MU42 A0A452DHX8 E1BC09 F1MFG7 F1MI11 F1ML85 F1MU22 F1MYL2 F1N015 G3X6I4 G3X6X4 G5E6I5 P07514 Q0P5F6 Q0VC97 Q1LZH1 Q29437 Q29RV2 Q3MHQ1 Q3SZT2 Q3T047 Q3ZCJ6 Q9TTK6	AADAC ABP1 AHR ALDH3A1 AOC1 AOC2 AOC3 ARNT ARNT2 BPHL CBR3 CES1 CES2 CES3 CMBL CYB5B CYB5R3 CYP2B6 CYP3A28 CYP3A4 CYP3A5 CYP3A74 CYP3A76 DIA1 EPHX1 LOC100138645 MARC2 MOSC2 MTARC1 MTARC2 NQO2	Bos taurus (cattle)
Ca activated K+ channels	Calcium-activated potassium channel subunit alpha-1 Calcium-activated potassium channel subunit beta-1 Calcium-activated potassium channel subunit beta Calcium-activated potassium channel subunit beta Potassium calcium-activated channel subfamily N member 1 Potassium calcium-activated channel subfamily N member 2 Potassium calcium-activated channel subfamily N member 3	E1BCE5 E1BGY2 E1BHB0 F1N467 Q1RMW7 Q28067 Q28204	KCNMA KCNMA1 KCNMB1 KCNMB2 KCNMB3 KCNMB4 KCNN1 KCNN2 KCNN3	Bos taurus (cattle)
Gluconeogenesis	Beta-enolase Enolase 4 Fructose-1,6-bisphosphatase 1 Fructose-1,6-bisphosphatase isozyme 2 Fructose-bisphosphate aldolase Fructose-bisphosphate aldolase Fructose-bisphosphate aldolase Glucose-6-phosphatase 3 Glucose-6-phosphatase catalytic subunit 1 Glucose-6-phosphatase Glucose-6-phosphate exchanger SLC37A2 Glucose-6-phosphate isomerase Glyceraldehyde-3-phosphate dehydrogenase, testis-specific Glyceraldehyde-3-phosphate dehydrogenase Phosphoenolpyruvate carboxykinase, cytosolic [GTP] Phosphoglycerate kinase 1 Phosphoglycerate mutase 1 Phosphoglycerate mutase Pyruvate carboxylase, mitochondrial Solute carrier family 37 member 1 Solute carrier family 37 member 4 Triosephosphate isomerase phosphoenolpyruvate carboxykinase (GTP) phosphopyruvate hydratase	A0A3Q1LIP1 A0A3Q1LMG1 A0A3Q1M1A8 A0A3Q1MDS5 A0A3S5ZPB0 A0A452DIX3 A6QR19 E1B9Q0 F1MDS3 F1MSR0 F1N2F2 F6RG16 G3MXL6 P10096 Q148G2 Q29RK2 Q29RU6 Q2KJE5 Q2KJJ9 Q3SZ62 Q3SZB7 Q3T0P6 Q3ZBD7 Q3ZC09	ALDOA ALDOB ALDOC ENO2 ENO3 ENO4 FBP1 FBP2 G6PC G6PC1 G6PC2 G6PC3 GAPD GAPDH GAPDHS GPI PC PCK1 PCK2 PGAM1 PGAM2 PGK1 SLC37A1 SLC37A2 SLC37A4 TPI1	Bos taurus (cattle)	G58161NS
TNFR2 non-canonical NF-kB pathway	26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 B-cell activating factor Baculoviral IAP repeat containing 2 Baculoviral IAP repeat-containing 3 CD40 ligand CD40 ligand LTBR protein Lymphotoxin-alpha Lymphotoxin-beta Mitogen-activated protein kinase kinase kinase 14 Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14 Proteasome 26S subunit, ATPase 3 Proteasome 26S subunit, ATPase 6 Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha type Proteasome subunit beta type-10 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Proteasome subunit beta Proteasome subunit beta TNF receptor superfamily member 11a TNF receptor superfamily member 12A TNF receptor superfamily member 13C TNF receptor superfamily member 1B TNF receptor-associated factor TNF receptor-associated factor TNF superfamily member 12 TNF superfamily member 14 Tumor necrosis factor ligand superfamily member Tumor necrosis factor receptor superfamily member 5 Tumor necrosis factor	A0A3Q1LHY0 A0A3Q1MKD6 A0A452DI44 A0A452DIT3 A0A452DIY4 A0A452DJ61 A6QQ46 A7MBA2 B0LKN7 E1B9D9 E1BBH2 E1BD83 E1BIP0 E1BK50 E1BL08 F1MBI1 F1MJD0 F1MLV1 F1MTC1 F1MWE0 F1MX43 F1MXE4 F1MYH8 F1N0K4 F1N6Z0 G3X822 G5E589 P33672 P56701 P62194 Q06600 Q17QP9 Q28203 Q2KI42 Q2KJ25 Q2KJ46 Q2KJE7 Q2YDE4 Q32KL2 Q3MHI9 Q3MHN0 Q3SX30 Q3SYW8 Q3SZ19 Q3SZC2 Q3T030 Q3T0T1 Q3T0X5 Q3T0Y5 Q3T108 Q3T112 Q3ZBD0 Q3ZBG0 Q3ZCK9 Q58DU5 Q5E964 Q5E987 Q5E9F9 Q5E9G3 Q5E9K0	BIRC2 BIRC3 CD40 CD40LG LTA LTB LTBR MAP3K14 NCR3 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 SUG1 TNF TNFB TNFRSF11A TNFRSF12A TNFRSF13C TNFRSF1B TNFRSF5 TNFSF1 TNFSF11 TNFSF12 TNFSF13B TNFSF14 TNLG1D TNLG7A TRAF2 TRAF3 TRAP2	Bos taurus (cattle)

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