GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **351 - 375** of **557** in total

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Pathway Name ▲	Protein Name	UniProt ID	Gene Symbol	Organism	GlyTouCan ID
PCP/CE pathway	Dishevelled associated activator of morphosis 1 Dishevelled segment polarity protein 1 Dishevelled segment polarity protein 2 Dishevelled segment polarity protein 3 Frizzled class receptor 3 Frizzled class receptor 7 Frizzled-1 Frizzled-6 Profilin-1 Protein Wnt Protein Wnt Protein Wnt Protein Wnt RAC3 protein Ras-related C3 botulinum toxin substrate 2 Transforming protein RhoA	A0A3Q1LHF1 A0A3Q1MDX6 A0A3Q1MJR6 A0A3Q1MSZ4 A5PK69 A7MB15 E1BDG5 E1BEN9 F1MMW6 F1MP23 F1N4C0 F1N4K7 F1N6M9 P02584 P61585 Q9TU25	ARHA DAAM1 DVL1 DVL2 DVL3 FZD1 FZD3 FZD6 FZD7 PFN1 RAC2 RAC3 RHO12 RHOA WNT1 WNT11 WNT4 WNT5A	Bos taurus (cattle)
PD-1 signaling	BOLA-DQA1 protein BoLA-DR-alpha Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein MHC class II antigen MHC class II antigen Major histocompatibility complex, class II, DQ alpha 5 Major histocompatibility complex, class II, DY alpha Programmed cell death 1 ligand 2 Programmed cell death-ligand 1 T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD3 zeta chain T-cell surface glycoprotein CD4 TRAV29-1*01 Tyrosine-protein kinase CSK Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type Tyrosine-protein phosphatase non-receptor type	A0A3Q1M088 A0A3Q1M2W6 A0A3Q1M3D2 A0A3Q1M739 A0A3Q1MT21 A6H6Y1 A6QQE7 C5NU11 E1BLZ1 F1MJK4 F1MJU5 F1ML60 F1N0X9 F1N339 G3MWT2 G8JL01 Q0VBZ0 Q0VCU4 Q28072 Q28073 Q30309 Q3ZCM0 Q70IB5	BLA-DQB BOLA-DQA1 BOLA-DQA2 BOLA-DQA5 BOLA-DRA BOLA-DRB2 BOLA-DRB3 BOLA-DYA BOLA-DYB BoLA-DIB BoLA-DRA BoLA-DYB CD247 CD274 CD3D CD3E CD3G CD4 CSK DYB HLA-DRA LCK LOC100848815 PD-L1 PDCD1LG2 PTPN11 PTPN6 TRAV29-1	Bos taurus (cattle)
PI Metabolism	TNF alpha induced protein 8 like 3 Tumor necrosis factor alpha-induced protein 8-like protein 1 Tumor necrosis factor alpha-induced protein 8-like protein 2 Tumor necrosis factor alpha-induced protein 8	A0A3Q1LVF0 A4IF78 A5PK29 Q3ZBK5	TNFAIP8 TNFAIP8L1 TNFAIP8L2 TNFAIP8L3	Bos taurus (cattle)
PI-3K cascade:FGFR1	Fibroblast growth factor 1 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GRB2-associated-binding protein 1 Growth factor receptor-bound protein 2 Klotho Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Tyrosine-protein phosphatase non-receptor type	A0A3Q1LUE0 A0A3Q1NAV6 A0MTF4 A6QLU3 D8KXU9 E1B7I9 E1BAI2 E1BGY3 E1BHC1 E1BJU2 E1BP37 F1N339 F1N6G8 G3MXR4 G3XGD3 P03968 P03969 P23727 P32871 Q3T0F9	AFGF FGF1 FGF10 FGF17 FGF2 FGF20 FGF23 FGF3 FGF4 FGF4A FGF5 FGF5C FGF6 FGF7B FGF8 FGF9 FGFA FGFR1 FRS2 Fgf4 GAB1 GRB2 HBGF-1 KL PIK3CA PIK3R1 PTPN11	Bos taurus (cattle)
PI-3K cascade:FGFR2	Fibroblast growth factor 1 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GRB2-associated-binding protein 1 Growth factor receptor-bound protein 2 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Tyrosine-protein phosphatase non-receptor type	A0A3Q1LRU7 A0A3Q1M3Q3 A0A3Q1NAV6 A0MTF4 A6QLU3 D8KXU9 E1B7I9 E1BGY3 E1BHC1 E1BJU2 E1BP37 F1MHC6 F1N339 F1N6G8 F2Z4J0 G3MXR4 G3XGD3 P03968 P03969 P23727 P32871 Q3T0F9	AFGF FGF1 FGF10 FGF16 FGF17 FGF18 FGF2 FGF20 FGF23 FGF3 FGF4 FGF4A FGF4C FGF5 FGF5B FGF5C FGF6 FGF6A FGF7 FGF7B FGF8 FGF9 FGFA FGFR2 FRS2 Fgf4 GAB1 GRB2 HBGF-1 PIK3CA PIK3R1 PTPN11	Bos taurus (cattle)
PI-3K cascade:FGFR3	Fibroblast growth factor 1 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GRB2-associated-binding protein 1 Growth factor receptor-bound protein 2 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Tyrosine-protein phosphatase non-receptor type	A0A3Q1MPT9 A0MTF4 A6QLU3 D8KXU9 E1B7I9 E1BJU2 E1BP37 F1MHC6 F1N339 F1N6G8 F2Z4J0 G3MXR4 G3XGD3 P03968 P03969 P23727 P32871 Q3T0F9	AFGF FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF23 FGF4 FGF4A FGF4C FGF5 FGF6A FGF8 FGF9 FGFA FGFR3 FRS2 Fgf4 GAB1 GRB2 HBGF-1 PIK3CA PIK3R1 PTPN11	Bos taurus (cattle)
PI3K Cascade	FLT3LG protein Fibroblast growth factor 1 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GRB2 associated binding protein 2 GRB2-associated-binding protein 1 Growth factor receptor-bound protein 2 Insulin receptor substrate 1 Insulin receptor substrate 2 Klotho beta Klotho Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Toll-like receptor 9 Tyrosine-protein phosphatase non-receptor type non-specific serine/threonine protein kinase phosphatidylinositol-4,5-bisphosphate 3-kinase receptor protein-tyrosine kinase	A0A3Q1LQK4 A0A3Q1LRU7 A0A3Q1LUE0 A0A3Q1M3Q3 A0A3Q1M864 A0A3Q1MPT9 A0A3Q1NAV6 A0MTF4 A2VE24 A5H631 A6QLU3 A6QLW1 D8KXU9 E1B7I9 E1BAI2 E1BFP8 E1BGY3 E1BHC1 E1BJU2 E1BP37 F1MHC6 F1MJE0 F1MN51 F1MRU0 F1MYE0 F1MYM3 F1N339 F1N4S9 F1N6G8 F2Z4J0 G3MXR4 G3XGD3 P03968 P03969 P23726 P23727 P32871 Q3T0F9	AFGF FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF23 FGF3 FGF4 FGF4A FGF4C FGF5 FGF5B FGF5C FGF6 FGF6A FGF7 FGF7B FGF8 FGF8A FGF9 FGFA FGFR1 FGFR2 FGFR3 FGFR4 FLT3 FLT3LG FRS2 Fgf4 GAB1 GAB2 GRB2 HBGF-1 IRS1 IRS2 KL KLB PIK3C3 PIK3CA PIK3CB PIK3R1 PIK3R2 PIK3R4 PTPN11 TLR9	Bos taurus (cattle)
PI3K/AKT Signaling	3-phosphoinositide-dependent protein kinase 1 Amphiregulin Betacellulin CD19 molecule CD80 molecule CD86 molecule Epiregulin Epithelial mitogen Estrogen receptor beta Estrogen receptor FLT3LG protein Fibroblast growth factor 1 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GRB2 associated binding protein 2 GRB2-associated-binding protein 1 Growth factor receptor-bound protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor Inducible T-cell costimulator Insulin receptor substrate 1 Insulin receptor substrate 2 Interleukin 1 receptor like 1 Interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase 4 Interleukin-33 Kit ligand Klotho beta Klotho Mast/stem cell growth factor receptor Myeloid differentiation primary response protein MyD88 Neuregulin 2 Neuregulin 3 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphoinositide-3-kinase adaptor protein 1 Phosphoinositide-3-kinase regulatory subunit 3 Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit A Platelet-derived growth factor subunit B Pro-neuregulin-1, membrane-bound isoform Proheparin-binding EGF-like growth factor Proto-oncogene vav Ras homolog family member G Ras-related C3 botulinum toxin substrate 2 Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Striatin T cell receptor associated transmembrane adaptor 1 T-cell-specific surface glycoprotein CD28 TNF receptor-associated factor 6 Transforming growth factor alpha Tyrosine-protein kinase Fyn Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type Uncharacterized protein phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase receptor protein-tyrosine kinase	A0A3Q1LRU7 A0A3Q1LUE0 A0A3Q1M3Q3 A0A3Q1M535 A0A3Q1M7J4 A0A3Q1M864 A0A3Q1MCW9 A0A3Q1ME99 A0A3Q1MGW7 A0A3Q1MHB0 A0A3Q1MKB4 A0A3Q1MLL9 A0A3Q1MPT9 A0A3Q1N3Z8 A0A3Q1NAV6 A0A3Q1ND77 A0A3S5ZP81 A0A452DHW6 A0A452DHX3 A0JNB0 A0MTF4 A2VE24 A2VE27 A6QLU3 A6QR62 B1H0W5 D8KXU9 E1B7I9 E1BAI2 E1BBE2 E1BDM2 E1BE66 E1BFL8 E1BFP8 E1BGY3 E1BHC1 E1BIM8 E1BIN8 E1BJU2 E1BP37 F1MCQ7 F1MDQ5 F1MEV4 F1MHC6 F1MJE0 F1MN51 F1MPD0 F1MQJ7 F1MRU0 F1MRU1 F1MS28 F1MYE0 F1MYM3 F1MZD6 F1N339 F1N4S9 F1N586 F1N6G8 F2Z4J0 G3MXR4 G3N104 G3XGD3 P03968 P03969 P23726 P23727 P32871 P49884 Q08DN7 Q08DU3 Q1RMI2 Q1RMT8 Q28132 Q2KJ15 Q2LGB3 Q3T0F9 Q3ZCC3 Q3ZCM0 Q58DF9 Q9TU25 Q9XSB5 Z4YHD9	AFGF AREG BTC CD19 CD28 CD80 CD86 EGFR EPGN ERBB2 ERBB3 ERBB4 EREG ESR ESR1 ESR2 FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF23 FGF3 FGF4 FGF4A FGF4C FGF5 FGF5B FGF5C FGF6 FGF6A FGF7 FGF7B FGF8 FGF8A FGF9 FGFA FGFR1 FGFR2 FGFR3 FGFR4 FLT3 FLT3LG FRS2 FYN Fgf4 GAB1 GAB2 GRB2 HBEGF HBGF-1 HGF ICOS IL1RL1 IL33 IRAK1 IRAK4 IRS1 IRS2 KIT KITLG KL KLB LCK MET MYD88 NR3A1 NR3A2 NRG1 NRG2 NRG3 PDGFA PDGFB PDGFRA PDGFRB PDPK1 PIK3AP1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PTPN11 RAC2 RHOG SCF SRC STRN TGFA TRAF6 TRAT1 VAV1	Bos taurus (cattle)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Alpha isoform of regulatory subunit A, protein phosphatase 2 Amphiregulin Betacellulin CD19 molecule CD80 molecule CD86 molecule Epiregulin Epithelial mitogen Estrogen receptor beta Estrogen receptor FLT3LG protein Fibroblast growth factor 1 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GRB2 associated binding protein 2 GRB2-associated-binding protein 1 Growth factor receptor-bound protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor Immediate early response 3 Inducible T-cell costimulator Insulin receptor substrate 1 Insulin receptor substrate 2 Insulin Interleukin 1 receptor like 1 Interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase 4 Interleukin-33 Kit ligand Klotho beta Klotho Mast/stem cell growth factor receptor Mitogen-activated protein kinase 1 Mitogen-activated protein kinase Myeloid differentiation primary response protein MyD88 Neuregulin 2 Neuregulin 3 PIP5K1A protein Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma Phosphatidylinositol-4-phosphate 5-kinase type 1 beta Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma Phosphatidylinositol-5-phosphate 4-kinase type 2 beta Phosphoinositide-3-kinase adaptor protein 1 Phosphoinositide-3-kinase regulatory subunit 3 Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit A Platelet-derived growth factor subunit B Pro-neuregulin-1, membrane-bound isoform Proheparin-binding EGF-like growth factor Protein phosphatase 2 scaffold subunit Abeta Proto-oncogene vav Ras homolog family member G Ras-related C3 botulinum toxin substrate 2 Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Striatin T cell receptor associated transmembrane adaptor 1 T-cell-specific surface glycoprotein CD28 TNF receptor-associated factor 6 Transforming growth factor alpha Tyrosine-protein kinase Fyn Tyrosine-protein kinase receptor Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type Uncharacterized protein phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase receptor protein-tyrosine kinase	A0A3Q1LRU7 A0A3Q1LUE0 A0A3Q1M3Q3 A0A3Q1M535 A0A3Q1M7J4 A0A3Q1M864 A0A3Q1MBL1 A0A3Q1MCW9 A0A3Q1ME99 A0A3Q1MGW7 A0A3Q1MHB0 A0A3Q1MKB4 A0A3Q1MLL9 A0A3Q1MPT9 A0A3Q1N3Z8 A0A3Q1NAV6 A0A3Q1ND77 A0A3S5ZP81 A0A452DHW6 A0A452DHX3 A0JNB0 A0MTF4 A2VDZ0 A2VE24 A2VE27 A4FV68 A5D973 A5PJB2 A6QLC5 A6QLU3 A6QR62 B1H0W5 D8KXU9 E1B7I9 E1B8P9 E1BAI2 E1BBE2 E1BDM2 E1BE66 E1BFL8 E1BFP8 E1BGY3 E1BHC1 E1BIM8 E1BIN8 E1BJU2 E1BP37 F1MCQ7 F1MDQ5 F1MEV4 F1MHC6 F1MHR4 F1MHT2 F1MJE0 F1MN51 F1MPD0 F1MQN0 F1MRU0 F1MRU1 F1MS28 F1MV64 F1MYE0 F1MYM3 F1MZD6 F1N1S8 F1N339 F1N4S9 F1N586 F1N6G8 F1N7M1 F2Z4J0 G3MXR4 G3N104 G3XGD3 P03968 P03969 P23726 P23727 P32871 P46196 P49884 P67774 Q08DN7 Q08DP7 Q08DU3 Q0P594 Q0P5F7 Q0P5G7 Q1RMI2 Q1RMT8 Q28132 Q2KJ15 Q2LGB3 Q3T0F9 Q3ZCC3 Q3ZCM0 Q58DF9 Q9TU25 Q9XSB5 Z4YHD9	AFGF AREG BTC CD19 CD28 CD80 CD86 EGFR EPGN ERBB2 ERBB3 ERBB4 EREG ERK2 ESR ESR1 ESR2 FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF23 FGF3 FGF4 FGF4A FGF4C FGF5 FGF5B FGF5C FGF6 FGF6A FGF7 FGF7B FGF8 FGF8A FGF9 FGFA FGFR1 FGFR2 FGFR3 FGFR4 FLT3 FLT3LG FRS2 FYN Fgf4 GAB1 GAB2 GRB2 HBEGF HBGF-1 HGF ICOS IER3 IL1RL1 IL33 INS INSR IRAK1 IRAK4 IRS1 IRS2 KIT KITLG KL KLB LCK MAPK1 MAPK3 MET MYD88 NR3A1 NR3A2 NRG1 NRG2 NRG3 PDGFA PDGFB PDGFRA PDGFRB PIK3AP1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP4K2B PIP4K2C PIP5K1A PIP5K1B PIP5K1C PIP5K2C PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5D PPP2R5E PRKM1 PTPN11 RAC2 RHOG SCF SRC STRN TGFA TRAF6 TRAT1 VAV1	Bos taurus (cattle)
PKA activation	Adenylate cyclase type 1 Adenylate cyclase type 2 Adenylate cyclase type 3 Adenylate cyclase type 4 Adenylate cyclase type 5 Adenylate cyclase type 6 Adenylate cyclase type 8 Calmodulin-like EF-hand domain-containing protein Protein kinase cAMP-dependent type I regulatory subunit beta adenylate cyclase cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase type II-alpha regulatory subunit cAMP-dependent protein kinase	A0A3Q1MA58 A0A3Q1MCI6 A0A3Q1MR28 A0A452DJE2 E1B9K3 E1BHU9 E1BM79 E1BQ12 F1MJV4 F1MLH6 F1MPC9 P00514 P00515 P00517 P19754	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY8 ADCY9 CALM PRKACA PRKACB PRKAR1A PRKAR1B PRKAR2A	Bos taurus (cattle)
PKMTs methylate histone lysines	ASH1 like histone lysine methyltransferase ASH2 like, histone lysine methyltransferase complex subunit Activating transcription factor 7 interacting protein Euchromatic histone lysine methyltransferase 1 Histone H3.1 Histone H3.2 Histone H4 Histone-binding protein RBBP4 Histone-binding protein RBBP7 Histone-lysine N-methyltransferase EZH2 Histone-lysine N-methyltransferase SETD7 Histone-lysine N-methyltransferase SETDB2 Histone-lysine N-methyltransferase, H3 lysine-79 specific Histone-lysine N-methyltransferase Histone-lysine N-methyltransferase Histone-lysine N-methyltransferase N-lysine methyltransferase KMT5A N-lysine methyltransferase SMYD2 NF-kappaB transcription factor p65 subunit NFKB2 protein Nuclear factor NF-kappa-B p105 subunit Nuclear receptor binding SET domain protein 1 Nuclear receptor binding SET domain protein 2 Nuclear receptor binding SET domain protein 3 PR/SET domain 16 PR/SET domain 9 PR/SET domain 9 Polycomb protein EED RBBP5 protein SET domain bifurcated histone lysine methyltransferase 1 SET domain containing 1A, histone lysine methyltransferase SET domain containing 1B, histone lysine methyltransferase SET domain containing 6, protein lysine methyltransferase SUZ12 polycomb repressive complex 2 subunit WD repeat domain 5 Zinc finger protein AEBP2 [histone H3]-lysine(4) N-methyltransferase [histone H3]-lysine(4) N-methyltransferase [histone H3]-lysine(4) N-trimethyltransferase [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B protein-histidine N-methyltransferase	A0A3Q1LX03 A0A3Q1M6A7 A0A3Q1M792 A0A3Q1M7L9 A0A3Q1MID6 A0A3Q1MJ82 A0A3Q1MSK4 A0A452DJ38 A1XG22 A4FUE3 A4FV57 A7MBB7 E1BEP4 E1BGA4 E1BKH5 E1BKN0 E1BLX2 E1BM66 E1BNH7 F1MHA1 F1MKW9 F1MMY4 F1MTF1 F1MUT0 F1MXG0 F1MYZ3 F1N093 F1N6Y5 F6R2J7 G3N3E5 G3X6G5 G3X6T4 G3X834 P62803 P68432 P84227 Q0P585 Q0P5C5 Q2YDJ8 Q3MHL3 Q3SWX8 Q3SZ25	AEBP2 ASH1L ASH2L ATF7IP DOT1L EED EHMT1 EZH2 KMT2A KMT2B KMT2C KMT5A KMT5B KMT5C NFKB1 NFKB2 NSD1 NSD2 NSD3 PRDM16 PRDM7 RBBP4 RBBP5 RBBP7 RELA SETD1A SETD1B SETD3 SETD6 SETD7 SETD8 SETDB1 SETDB2 SMYD2 SMYD3 SUV39H1 SUV39H2 SUZ12 WDR5	Bos taurus (cattle)
PLC beta mediated events	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase Guanine nucleotide-binding protein subunit alpha-11 Guanine nucleotide-binding protein subunit alpha-14 Guanine nucleotide-binding protein subunit alpha Guanine nucleotide-binding protein subunit alpha	E1BA29 F1MSD7 F1N2V3 P10894 P38408 P38409	GNA11 GNA14 GNA15 GNAQ PLCB1 PLCB4	Bos taurus (cattle)
Passive transport by Aquaporins	Aquaporin 10 Aquaporin 5 Aquaporin 7 Aquaporin 8 Aquaporin 9 Aquaporin-1 Aquaporin-2 Aquaporin-3 Aquaporin-4 Aquaporin Aquaporin Lens fiber major intrinsic protein	A0A3Q1LWN9 A0A3S5ZPM1 E1BDW5 F1MNJ1 F1N1C3 F1N3R5 F1N7X5 O77750 P06624 P47865 P79099 Q08DE6	AQP1 AQP10 AQP11 AQP12 AQP2 AQP3 AQP4 AQP5 AQP6 AQP7 AQP8 AQP9 MIP	Bos taurus (cattle)
Pentose phosphate pathway	6-phosphogluconate dehydrogenase, decarboxylating 6-phosphogluconolactonase Deoxyribose-phosphate aldolase Glucose-6-phosphate 1-dehydrogenase Phosphoglucomutase 2 Ribokinase Ribulose-phosphate 3-epimerase Sedoheptulokinase Transaldolase Transketolase ribose-5-phosphate isomerase	A0A3Q1MM55 A0A3S5ZPM3 A0A3S5ZPP1 A5D7P1 A7Z014 E1BJH7 F1MM83 F6QEU6 G5E534 G5E5C8 Q3T0V9	DERA G6PD PGD PGLS PGM2 RBKS RPE RPIA SHPK TALDO1 TKT	Bos taurus (cattle)	G31080DL
Peptide hormone biosynthesis	Neuroendocrine convertase 1 Pro-opiomelanocortin	F1MFR6 P01190	PCSK1 POMC	Bos taurus (cattle)
Peptide ligand-binding receptors	APLNR protein Adrenocorticotropic hormone receptor Angiotensinogen Apelin Atypical chemokine receptor 1 B1 bradykinin receptor Bombesin receptor subtype-3 C3a anaphylatoxin chemotactic receptor C5L2 C5a anaphylatoxin chemotactic receptor 1 Cholecystokinin Coagulation factor II (Thrombin) receptor-like 2 Complement C3 Complement C5 Cortistatin Endothelin receptor type B Endothelin-1 receptor Endothelin-1 Endothelin-2 Endothelin-3 Endothelin-converting enzyme 1 Endothelin-converting enzyme 2 F2R like thrombin or trypsin receptor 3 F2R like trypsin receptor 1 G protein-coupled receptor 37 like 1 G protein-coupled receptor 37 GALR2 protein Galanin peptides Galanin receptor 1 Galanin receptor 3 Gastrin releasing peptide receptor Gastrin-releasing peptide Gastrin/cholecystokinin type B receptor Interleukin-8 KISS1 receptor Kappa-type opioid receptor KiSS-1 metastasis suppressor Kininogen 1 Melanin concentrating hormone receptor 2 Melanin-concentrating hormone receptor 1 Melanocortin receptor 4 Melanocortin receptor 5 Melanocortin-3-receptor Melanocyte-stimulating hormone receptor Motilin receptor Mu-type opioid receptor Neurolysin, mitochondrial Neuromedin B receptor Neuromedin S Neuromedin U receptor 1 Neuromedin U receptor 2 Neuropeptide B Neuropeptide S receptor 1 Neuropeptide S Neuropeptide Y receptor type 1 Neuropeptide Y receptor type 2 Neuropeptide Y receptor type 5 Neuropeptides B and W receptor 1 Neuropeptides B/W receptor type 2 Neurotensin receptor 1 Neurotensin receptor 2 Neurotensin/neuromedin N Nociceptin receptor Opioid receptor delta 1 Pancreatic polypeptide receptor 1 Pancreatic polypeptide Peptide YY Prepronociceptin Pro-MCH Pro-neuropeptide Y Pro-opiomelanocortin Pro-thyrotropin-releasing hormone Proenkephalin-A Proenkephalin-B Prokineticin 1 Prokineticin 2 Prokineticin receptor 2 Prolactin-releasing peptide receptor Promotilin Prosaposin Proteinase-activated receptor 1 Prothrombin Somatostatin receptor 1 Somatostatin receptor type 2 Somatostatin receptor type 5 Somatostatin Thyrotropin-releasing hormone receptor Type-1 angiotensin II receptor Type-2 angiotensin II receptor	A0A140T858 A0A140T8C6 A0A140T8C8 A0A3Q1LWC2 A0A3Q1MCT6 A0A3Q1MSN3 A0A3Q1MXN7 A0A3Q1MXY0 A0A452DI66 A0A452DII4 A0A452DIK5 A0A452DJT3 A0A452DKE4 A1Z2Z3 A4IFB7 A4IFF5 A6QL98 A6QLK3 A6QLQ7 A6QM11 A6QQX6 B1H0W3 C3W8S1 E1B8V8 E1B9Q7 E1BCM7 E1BCZ7 E1BFS5 E1BFV6 E1BKZ6 E1BL07 E1BMI3 E1BMN4 F1MCC4 F1MEN6 F1MJD1 F1MJZ0 F1MKB6 F1MMX1 F1MN36 F1MPG4 F1MPN9 F1MV99 F1MWG2 F1MY53 F1MY85 F1N018 F1N083 F1N145 F1N476 F1N4J9 F1N4Y7 F1N5B6 G3N364 G3X795 G5E5J0 G5E6F7 O46639 O62647 P01017 P01156 P01190 P01211 P11242 P17322 P21450 P25104 P28088 P34974 P41520 P42891 P47798 P51694 P56451 P79255 Q08DZ7 Q0VD43 Q1RMU8 Q2KIP6 Q2UVX4 Q4EW11 Q673L2 Q6RUW3 Q863C3 Q867A9 Q8MJV2 Q8MJV4 Q8SPN1 Q9GLJ8	ACKR1 AGT AGTR1 AGTR2 APLN APLNR BDKRB2 BRS3 C3 C3AR1 C5 C5AR1 C5AR2 C5L2 CCK CCKBR CORT CXCL8 ECE1 ECE2 EDN1 EDN2 EDN3 EDNRA EDNRB F2 F2R F2RL1 F2RL2 F2RL3 GAL GALN GALR1 GALR2 GALR3 GPR10 GPR37 GPR37L1 GPR73L1 GPR77 GPR8 GRP GRPR IL8 KISS1 KISS1R KNG1 LOC112445811 MC1R MC2R MC3R MC4R MC5R MCHR1 MCHR2 MLN MLNR MSHR NLN NMBR NMS NMUR1 NMUR2 NPB NPBWR1 NPBWR2 NPS NPSR1 NPY NPY1R NPY2R NPY4R NPY5R NTS NTSR1 NTSR2 OPRD1 OPRK1 OPRL1 OPRM1 PDYN PENK PKR2 PMCH PNOC POMC PPY PPYR1 PRLHR PROK1 PROK2 PROKR2 PSAP PYY SERPINA8 SST SSTR1 SSTR2 SSTR5 TRH TRHR mln	Bos taurus (cattle)
Phase 0 - rapid depolarisation	Calcium voltage-gated channel auxiliary subunit alpha2delta 2 Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calmodulin-like EF-hand domain-containing protein Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor RAN guanine nucleotide release factor Sodium channel protein Sodium channel protein Sodium channel protein Sodium channel protein Sodium channel protein Sodium channel protein Sodium channel regulatory subunit beta-3 Sodium channel subunit beta-1 Sodium channel subunit beta-4 Sodium voltage-gated channel beta subunit 2 Voltage-dependent L-type calcium channel subunit alpha Voltage-dependent L-type calcium channel subunit beta-1 Voltage-dependent L-type calcium channel subunit beta-2 Voltage-dependent calcium channel gamma-4 subunit Voltage-dependent calcium channel gamma-6 subunit Voltage-dependent calcium channel gamma-7 subunit Voltage-dependent calcium channel gamma-8 subunit calcium/calmodulin-dependent protein kinase	A0A3Q1LKG2 A0A3Q1LLX7 A0A3Q1MKC7 A0A3Q1MR28 A0A3Q1NE86 E1B757 E1B9G2 E1BHM6 E1BIG3 E1BLK4 E1BLM4 F1MHP0 F1MLH6 F1MV40 F1MW14 F1MX37 F1N5T3 F6QLW0 M0QVY7 M0QW12 Q08E08 Q17QN4 Q2HJF7 Q2KI11 Q3MHJ9 Q9MZL5 Q9MZL7	CACNA1C CACNA2D2 CACNB1 CACNB2 CACNG4 CACNG6 CACNG7 CACNG8 CALM CAMK2A CAMK2B CAMK2D FGF12 FGF13 FGF14 RANGRF SCN11A SCN1A SCN1B SCN2B SCN3A SCN3B SCN4B SCN5A SCN8A SCN9A	Bos taurus (cattle)
Phase 1 - inactivation of fast Na+ channels	Kv channel-interacting protein 4 Potassium voltage-gated channel interacting protein 1 Potassium voltage-gated channel interacting protein 2 Potassium voltage-gated channel interacting protein 3 Potassium voltage-gated channel subfamily D member 1 Potassium voltage-gated channel subfamily D member 2 Potassium voltage-gated channel subfamily D member 3	A0A3Q1LV43 A0A3Q1M5I5 A0A3Q1M784 F1MVI5 F1MY95 Q2KI69 Q52PG9	KCND1 KCND2 KCND3 KCNIP1 KCNIP2 KCNIP3 KCNIP4	Bos taurus (cattle)
Phase 2 - plateau phase	Calcium voltage-gated channel auxiliary subunit alpha2delta 2 KCNE1-like MinK-related peptide 3 Potassium voltage-gated channel subfamily E member 1 Potassium voltage-gated channel subfamily E member 2 Potassium voltage-gated channel subfamily KQT member 1 Uncharacterized protein Voltage-dependent L-type calcium channel subunit alpha Voltage-dependent L-type calcium channel subunit beta-1 Voltage-dependent L-type calcium channel subunit beta-2 Voltage-dependent calcium channel gamma-4 subunit Voltage-dependent calcium channel gamma-6 subunit Voltage-dependent calcium channel gamma-7 subunit Voltage-dependent calcium channel gamma-8 subunit	A0A3Q1LKG2 A0A3Q1MT75 A2VDV8 E1BGG9 E1BIG3 E1BLK4 F1MV40 F1MX37 F1N5T3 Q0IIF1 Q2KHV0 Q2NKS7 Q9MZL5 Q9MZL7	CACNA1C CACNA2D2 CACNB1 CACNB2 CACNG4 CACNG6 CACNG7 CACNG8 KCNE1 KCNE1L KCNE2 KCNE3 KCNE4 KCNE5 KCNQ1	Bos taurus (cattle)
Phase 4 - resting membrane potential	ATP-sensitive inward rectifier potassium channel 12 Inward rectifier potassium channel 2 Potassium channel subfamily K member 1 Potassium channel subfamily K member 9 Potassium channel subfamily K member Potassium channel subfamily K member Potassium channel subfamily K member Potassium inwardly rectifying channel subfamily J member 14 Potassium inwardly rectifying channel subfamily J member 4 Potassium two pore domain channel subfamily K member 10 Potassium two pore domain channel subfamily K member 12 Potassium two pore domain channel subfamily K member 13 Potassium two pore domain channel subfamily K member 15 Potassium two pore domain channel subfamily K member 16 Potassium two pore domain channel subfamily K member 18 Potassium two pore domain channel subfamily K member 2 Potassium two pore domain channel subfamily K member 4 Potassium two pore domain channel subfamily K member 5	A0A3Q1LQ50 A0A3Q1M4V6 A0A3Q1MT89 E1B9M4 E1BCI4 E1BEH1 E1BEH3 E1BGH7 E1BIA3 E1BNW6 F1MLI5 F1MW24 G3N1D1 G3N1Q6 O19182 Q0P5A0 Q4TZY1 Q8HZT2	IRK1 KCNJ12 KCNJ14 KCNJ2 KCNJ4 KCNK1 KCNK10 KCNK12 KCNK13 KCNK15 KCNK16 KCNK17 KCNK18 KCNK2 KCNK3 KCNK4 KCNK5 KCNK7 KCNK9	Bos taurus (cattle)
Phase I - Functionalization of compounds	Aldehyde dehydrogenase Alpha/beta hydrolase fold-3 domain-containing protein Amine oxidase [copper-containing] 3 Amine oxidase Amine oxidase Amine oxidase Aryl hydrocarbon receptor nuclear translocator 2 Aryl hydrocarbon receptor nuclear translocator Aryl hydrocarbon receptor Arylacetamide deacetylase Biphenyl hydrolase like CYB5B protein Carbonyl reductase (NADPH) Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxymethylenebutenolidase homolog Cytochrome P450 3A Cytochrome P450 3A Cytochrome P450 3A Cytochrome P450 3A Cytochrome P450 family 2 subfamily B member 6 Epoxide hydrolase Mitochondrial amidoxime reducing component 1 Mitochondrial amidoxime reducing component 2 NAD(P)H dehydrogenase, quinone 2 NADH-cytochrome b5 reductase 3 Primary amine oxidase, liver isozyme	A0A3Q1LGS8 A0A3Q1LKX3 A0A3Q1LZ03 A0A3Q1M7J3 A0A3Q1MQJ1 A0A3Q1MU42 A0A452DHX8 E1BC09 F1MFG7 F1MI11 F1ML85 F1MU22 F1MYL2 F1N015 G3X6I4 G3X6X4 G5E6I5 P07514 Q0P5F6 Q0VC97 Q1LZH1 Q29437 Q29RV2 Q3MHQ1 Q3SZT2 Q3T047 Q3ZCJ6 Q9TTK6	AADAC ABP1 AHR ALDH3A1 AOC1 AOC2 AOC3 ARNT ARNT2 BPHL CBR3 CES1 CES2 CES3 CMBL CYB5B CYB5R3 CYP2B6 CYP3A28 CYP3A4 CYP3A5 CYP3A74 CYP3A76 DIA1 EPHX1 LOC100138645 MARC2 MOSC2 MTARC1 MTARC2 NQO2	Bos taurus (cattle)
Phospholipase C-mediated cascade: FGFR1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma Fibroblast growth factor 1 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Klotho	A0A3Q1LUE0 A0A3Q1NAV6 A0MTF4 D8KXU9 E1BAI2 E1BGY3 E1BHC1 E1BJU2 E1BP37 F1MYF9 F1N6G8 G3MXR4 G3XGD3 P03968 P03969	AFGF FGF1 FGF10 FGF17 FGF2 FGF20 FGF23 FGF3 FGF4 FGF4A FGF5 FGF5C FGF6 FGF7B FGF8 FGF9 FGFA FGFR1 Fgf4 HBGF-1 KL PLCG1	Bos taurus (cattle)
Phospholipase C-mediated cascade; FGFR2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma Fibroblast growth factor 1 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor	A0A3Q1LRU7 A0A3Q1M3Q3 A0A3Q1NAV6 A0MTF4 D8KXU9 E1BGY3 E1BHC1 E1BJU2 E1BP37 F1MHC6 F1MYF9 F1N6G8 F2Z4J0 G3MXR4 G3XGD3 P03968 P03969	AFGF FGF1 FGF10 FGF16 FGF17 FGF18 FGF2 FGF20 FGF23 FGF3 FGF4 FGF4A FGF4C FGF5 FGF5B FGF5C FGF6 FGF6A FGF7 FGF7B FGF8 FGF9 FGFA FGFR2 Fgf4 HBGF-1 PLCG1	Bos taurus (cattle)
Phospholipase C-mediated cascade; FGFR3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma Fibroblast growth factor 1 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor	A0A3Q1MPT9 A0MTF4 D8KXU9 E1BJU2 E1BP37 F1MHC6 F1MYF9 F1N6G8 F2Z4J0 G3MXR4 G3XGD3 P03968 P03969	AFGF FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF23 FGF4 FGF4A FGF4C FGF5 FGF6A FGF8 FGF9 FGFA FGFR3 Fgf4 HBGF-1 PLCG1	Bos taurus (cattle)
Phosphorylation of CD3 and TCR zeta chains	BOLA-DQA1 protein BoLA-DR-alpha Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein MHC class II antigen MHC class II antigen Major histocompatibility complex, class II, DQ alpha 5 Major histocompatibility complex, class II, DY alpha Phosphoprotein membrane anchor with glycosphingolipid microdomains 1 T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD3 zeta chain T-cell surface glycoprotein CD4 TRAV29-1*01 Tyrosine-protein kinase CSK Tyrosine-protein kinase peptidylprolyl isomerase protein-tyrosine-phosphatase protein-tyrosine-phosphatase	A0A3Q1M088 A0A3Q1M3D2 A0A3Q1M6K1 A0A3Q1MT21 A6H6Y1 A6QQE7 E1BLZ1 F1MJK4 F1MJS9 F1MJU5 F1ML60 F1MQC1 F1N0X9 F1N6L3 G3MWT2 G8JL01 Q0VBZ0 Q0VCU4 Q28072 Q28073 Q30309 Q3ZCM0 Q70IB5	BLA-DQB BOLA-DQA1 BOLA-DQA2 BOLA-DQA5 BOLA-DRA BOLA-DRB2 BOLA-DRB3 BOLA-DYA BOLA-DYB BoLA-DIB BoLA-DRA BoLA-DYB CD247 CD3D CD3E CD3G CD4 CSK DYB HLA-DRA LCK LOC100848815 PAG1 PTPN22 PTPRC PTPRJ TRAV29-1	Bos taurus (cattle)

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