GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **526 - 550** of **557** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism ▼	GlyTouCan ID
Regulation of insulin secretion	ATP binding cassette subfamily C member 8 ATP-sensitive inward rectifier potassium channel 11 Calcium voltage-gated channel auxiliary subunit alpha2delta 2 Rap guanine nucleotide exchange factor 3 Rap guanine nucleotide exchange factor 4 Solute carrier family 2, facilitated glucose transporter member 1 Solute carrier family 2, facilitated glucose transporter member 2 Voltage-dependent L-type calcium channel subunit alpha Voltage-dependent L-type calcium channel subunit alpha Voltage-dependent L-type calcium channel subunit beta-2 Voltage-dependent L-type calcium channel subunit beta-3 cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase	A0A3Q1LHN3 A0A3Q1LQ06 A0A452DJE2 A2VDS4 E1BKR6 E1BPX7 F1MTK5 F1MX37 F1N5T3 P00517 P27674 P58351 Q9MZL5	ABCC8 CACNA1C CACNA1D CACNA2D2 CACNB2 CACNB3 GLUT1 GLUT2 KCNJ11 PRKACA PRKACB RAPGEF3 RAPGEF4 SLC2A1 SLC2A2	Bos taurus (cattle)	G58161NS
RHOC GTPase cycle	A-kinase anchoring protein 13 ABCD3 protein Active breakpoint cluster region-related protein Acyl-CoA-binding domain-containing protein 5 Anillin, actin binding protein BCR activator of RhoGEF and GTPase Caveolae associated protein 1 Caveolin-1 Coiled-coil domain containing 187 Complement component 1 Q subcomponent-binding protein, mitochondrial DEP domain containing 1B Delta(14)-sterol reductase LBR Diaphanous related formin 1 Diaphanous related formin 3 Dishevelled associated activator of morphosis 1 Flotillin-1 Flotillin-2 Formin like 3 Formin-like protein 2 IQ motif containing GTPase activating protein 1 IQGAP3 protein Junction plakoglobin Lectin, mannose binding 1 MCF.2 cell line derived transforming sequence like MCF.2 cell line derived transforming sequence Melanoma cell adhesion molecule Myosin IXB Oligophrenin-1 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 Rac GTPase activating protein 1 Rho GDP-dissociation inhibitor 1 Rho GTPase activating protein 18 Rho GTPase activating protein 1 Rho GTPase activating protein 32 Rho GTPase activating protein 39 Rho GTPase activating protein 5 Rho GTPase-activating protein 26 Rho GTPase-activating protein 35 Rho GTPase-activating protein 7 Rho guanine nucleotide exchange factor 10 like Rho guanine nucleotide exchange factor 10 Rho guanine nucleotide exchange factor 11 Rho guanine nucleotide exchange factor 12 Rho guanine nucleotide exchange factor 17 Rho guanine nucleotide exchange factor 1 Rho guanine nucleotide exchange factor 25 Rho guanine nucleotide exchange factor 28 Rho guanine nucleotide exchange factor 5 Rho-associated protein kinase Rho-related GTP-binding protein RhoC Rhotekin STOM protein Serine/threonine-protein kinase N1 StAR related lipid transfer domain containing 13 Syntaxin-5 Tight junction protein 2 Transferrin receptor protein 1 Transforming protein RhoA Vang-like protein Vav guanine nucleotide exchange factor 2 Vesicle-associated membrane protein-associated protein B non-specific serine/threonine protein kinase non-specific serine/threonine protein kinase protein kinase C protein kinase C	A0A3Q1LFQ5 A0A3Q1LHF1 A0A3Q1LKT3 A0A3Q1LM61 A0A3Q1LNB6 A0A3Q1LNE2 A0A3Q1LQ45 A0A3Q1LSX9 A0A3Q1LUD9 A0A3Q1LUW4 A0A3Q1LWV5 A0A3Q1M4M7 A0A3Q1M851 A0A3Q1MEH9 A0A3Q1MN47 A0A3Q1MQP9 A0A3Q1MRV3 A0A3Q1MSA1 A0A3Q1MW77 A0A3Q1N6F4 A0A3Q1N6J8 A0A452DJ82 A1A4I4 A2VDZ9 A6H7H0 A6QLR4 A6QNS3 A6QQV8 A7Z038 A8E4P3 E1B718 E1B801 E1BH05 E1BHQ9 E1BIG6 E1BJP2 E1BLB3 E1BM23 E1BMN2 E1BNE7 E1BNR7 E1BNV7 E1BP14 F1MBT6 F1MC48 F1MCN4 F1MDL7 F1MEK6 F1MF50 F1MFK1 F1MIZ6 F1MJH8 F1MS34 F1N1Q7 F1N2G5 F1N7Q8 F6RWK1 G3X696 P23727 P61585 P79132 Q08DB5 Q08DN8 Q1RMJ6 Q3T0B6 Q8SPJ1	ABCD3 ABR ACBD5 AKAP13 ANLN ARHA ARHC ARHGAP1 ARHGAP18 ARHGAP26 ARHGAP32 ARHGAP35 ARHGAP39 ARHGAP5 ARHGDIA ARHGEF1 ARHGEF10 ARHGEF10L ARHGEF11 ARHGEF12 ARHGEF17 ARHGEF25 ARHGEF28 ARHGEF5 BCR C1QBP CAV1 CAVIN1 DAAM1 DEPDC1B DIAPH1 DIAPH3 DLC1 FLOT1 FLOT2 FMNL2 FMNL3 IQGAP1 IQGAP3 JUP LBR LMAN1 LOC787891 MCAM MCF2L MYO9B OPHN1 PIK3R1 PKN PKN1 PKN2 PKN3 PREX1 PRK1 PRKCL1 RACGAP1 RHO12 RHOA RHOC ROCK1 ROCK2 RTKN SLK STARD13 STOM STX5 TFRC TJP2 VANGL1 VAPB VAV2	Bos taurus (cattle)
Lectin pathway of complement activation	Collectin subfamily member 10 Collectin-11 Ficolin-2 MBL associated serine protease 1 MBL associated serine protease 2 Mannose-binding protein C	A0A3Q1MLF4 E1BJ49 F1MVS9 O02659 Q17QH6 Q5I2E5	COLEC10 COLEC11 FCN2 MASP1 MASP2 MBL	Bos taurus (cattle)	G49108TO G57321FI
FGFRL1 modulation of FGFR1 signaling	Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor receptor like 1 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor	A0A3Q1NAV6 A0MTF4 E1BGY3 E1BJU2 F1MQI5 F1N6G8 F2Z4J0 G3MXR4 G3XGD3 P03969	FGF10 FGF17 FGF18 FGF2 FGF23 FGF3 FGF4 FGF5 FGF5C FGF6A FGF8 FGFRL1 Fgf4	Bos taurus (cattle)
Mitotic Prometaphase	AT-hook containing transcription factor 1 Alpha isoform of regulatory subunit A, protein phosphatase 2 Aurora kinase B9 domain-containing protein 2 BUB1 mitotic checkpoint serine/threonine kinase B BUB1 protein Baculoviral IAP repeat-containing protein 5 Borealin CAP-Gly domain containing linker protein 1 CENPI protein CENPP protein Cell division cycle 20 Centromere protein C Centromere protein E Centromere protein F Centromere protein H Centromere protein K Centromere protein L Centromere protein M Centromere protein N Centromere protein O Centromere protein Q Centromere protein S Centromere protein T Cytoplasmic dynein 1 intermediate chain 1 Cytoplasmic linker associated protein 1 Cytoplasmic linker associated protein 2 Cytoskeleton associated protein 5 DNA excision repair protein ERCC-6-like DSN1 component of MIS12 kinetochore complex Dynein cytoplasmic 1 heavy chain 1 Dynein light chain 1, cytoplasmic Dynein light chain 2, cytoplasmic Dynein light intermediate chain Dynein light intermediate chain Exportin 1 Histone H3-like centromeric protein A Inner centromere protein Integrin subunit beta 3 binding protein Kinesin-like protein Kinetochore associated 1 Kinetochore protein NDC80 Kinetochore protein Spc24 Kinetochore protein Spc25 Kinetochore scaffold 1 Microtubule-associated protein RP/EB family member 1 Mitotic arrest deficient 1 like 1 Mitotic arrest deficient 2 like 1 Mitotic checkpoint protein BUB3 NDE1 protein NSL1 protein NUF2 component of NDC80 kinetochore complex NUP43 protein Nuclear distribution protein nudE-like 1 Nuclear migration protein nudC Nuclear pore complex protein Nup85 Nuclear pore complex protein Nup98-Nup96 Nuclear pore complex protein Nucleoporin 133 Nucleoporin 160 Nucleoporin 37 Nucleoporin SEH1 Platelet-activating factor acetylhydrolase IB subunit alpha Polyamine-modulated factor 1 Protein MIS12 homolog Protein SEC13 homolog Protein Spindly Protein phosphatase 2 scaffold subunit Abeta Protein zwilch homolog RAN binding protein 2 RCC2 protein Ran GTPase activating protein 1 Serine/threonine-protein kinase PLK1 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Serine/threonine-protein phosphatase PP1-gamma catalytic subunit Shugoshin 1 Shugoshin 2 Small ribosomal subunit protein eS27 Spindle and kinetochore-associated protein 1 Spindle and kinetochore-associated protein 2 ZW10 interacting kinetochore protein ZW10, kinetochore associated, homolog (Drosophila) non-specific serine/threonine protein kinase	A0A3Q1LLS4 A0A3Q1LQI2 A0A3Q1LTH6 A0A3Q1M302 A0A3Q1M6A8 A0A3Q1MAP0 A0A3Q1MMV9 A0A3Q1MQQ6 A0A3Q1MWV1 A0A3Q1NEK5 A0A3Q1NEU9 A2VDZ0 A3KMW1 A4FV68 A4IFM5 A5D7P3 A5D973 A6H7B3 A6QL85 A6QLS4 A6QLW0 A6QM04 A6QPS5 A6QQ16 A6QQ81 A6QQR4 A7YWP8 A7YY75 E1B7K5 E1BAK5 E1BBQ0 E1BCV4 E1BD42 E1BDU0 E1BE98 E1BF82 E1BG49 E1BJ19 E1BLA0 E1BQ15 F1MBQ0 F1MFD5 F1MGX8 F1MLG9 F1MM55 F1MNP7 F1MQN0 F1MR95 F1MRW5 F1MT24 F1MUQ7 F1MWP1 F1MZR0 F1N0Y3 F1N1F8 F1N1S8 F1N7G9 G3MX31 G3MXW4 G3N2Y5 G5E613 P61285 P61287 P67774 Q08DN4 Q08DP7 Q08DW5 Q0P594 Q0P5L6 Q17QG2 Q1JQB2 Q29RQ3 Q2KHT7 Q2KII9 Q2T9N4 Q2TA25 Q2TBH1 Q2TBR7 Q3MHR3 Q3T0L1 Q3ZBD9 Q3ZBK3 Q3ZBK8 Q3ZC98 Q3ZCC9 Q5EA18 Q5EA49 Q6J1J1	AHCTF1 APITD1 AURKB B9D2 BIRC5 BUB1 BUB1B BUB3 CCDC99 CDC20 CDCA8 CENPC CENPE CENPF CENPH CENPI CENPK CENPL CENPM CENPO CENPP CENPQ CENPS CENPT CKAP5 CLASP1 CLASP2 CLIP1 DNCL1 DSN1 DYNC1H1 DYNC1I1 DYNC1LI1 DYNC1LI2 DYNLL1 DYNLL2 ERCC6L FAAP16 INCENP ITGB3BP KIF2B KNL1 KNTC1 LIS1 MAD1L1 MAD2L1 MAPRE1 MCM21R MHF1 MIS12 NDC80 NDE1 NDEL1 NSL1 NUDC NUF2 NUP107 NUP133 NUP160 NUP37 NUP43 NUP85 NUP98 PAFAH1B1 PLK1 PMF1 PPP1CC PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5D PPP2R5E RANBP2 RANGAP1 RCC2 RPS27 SEC13 SEC13L1 SEH1L SGO1 SGO2 SKA1 SKA2 SPBC25 SPC24 SPC25 SPDL1 TAOK1 XPO1 ZW10 ZWILCH ZWINT	Bos taurus (cattle)
Iron uptake and transport	Broad substrate specificity ATP-binding cassette transporter ABCG2 Cullin 1 Cullin-associated NEDD8-dissociated protein 1 Cytoplasmic aconitate hydratase F-box/LRR-repeat protein 5 FLVCR heme transporter 1 Ferritin heavy chain Ferritin light chain Ferritin Heme oxygenase 1 Hephaestin Iron-responsive element-binding protein 2 Lipocalin 2 NEDD8 Plasma membrane ascorbate-dependent reductase CYBRD1 Polyubiquitin-B Polyubiquitin-C Proton-coupled folate transporter S-phase kinase-associated protein 1 Serotransferrin Solute carrier family 11 member 2 Solute carrier family 22 member 17 Solute carrier family 40 member Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein ferroxidase heme oxygenase (biliverdin-producing)	A0A3Q1MHC4 A0A3Q1MRJ4 A0A3Q1MUL6 A0JNB7 A2VE78 A7MBJ5 B2D1N9 E1B6Z6 E1B7A6 F1MLZ1 F1MMZ2 F1MTY9 F1MYD0 F1N076 G3MXE7 G3X6N3 O46414 O46415 P0CG53 P0CH28 P61282 P62992 P63048 Q05B81 Q3SZQ2 Q3ZCF3 Q5E9F2	ABCG2 ACO1 CAND1 CP CUL1 CYBRD1 FBXL5 FLVCR1 FTH FTH1 FTL FTMT HCP1 HEPH HMOX1 HMOX2 IREB2 LCN2 NEDD8 PCFT RPS27A SKP1 SKP1A SLC11A2 SLC22A17 SLC40A1 SLC46A1 TF UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Bos taurus (cattle)
Ubiquinol biosynthesis	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial 4-hydroxybenzoate polyprenyltransferase, mitochondrial 5-demethoxyubiquinone hydroxylase, mitochondrial Atypical kinase COQ8A, mitochondrial Decaprenyl diphosphate synthase subunit 1 Decaprenyl diphosphate synthase subunit 2 Ubiquinone biosynthesis O-methyltransferase, mitochondrial Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial Ubiquinone biosynthesis protein COQ9, mitochondrial	A6QR05 E1BK08 F1N1G6 F1N5A4 F6RJN8 Q0P5A2 Q29RI0 Q2KIL4 Q2NL34 Q58CW1	ADCK3 CABC1 COQ2 COQ3 COQ4 COQ5 COQ6 COQ7 COQ8A COQ9 PDSS1 PDSS2	Bos taurus (cattle)
Transport of inorganic cations/anions and amino acids/oligopeptides	Amino acid transporter Amino acid transporter Amino acid transporter Amino acid transporter Cystinosin Excitatory amino acid transporter 1 Mitochondrial S-adenosylmethionine carrier protein Vesicular inhibitory amino acid transporter	A0A3Q1MR13 A6H774 A6QR09 A7MB63 F1MJN4 F1MUT8 G3N354 P46411	CTNS EAAT1 GLAST GLAST1 SAMC SLC1A1 SLC1A2 SLC1A3 SLC1A6 SLC1A7 SLC25A26 SLC32A1	Bos taurus (cattle)
Transport of vitamins, nucleosides, and related molecules	PDZ domain-containing protein 11 Solute carrier family 33 (Acetyl-CoA transporter), member 1 Solute carrier family 5 member 6	F1MN65 Q0VCP0 Q32LE7	PDZD11 SLC33A1 SLC5A6	Bos taurus (cattle)
Glycogen breakdown (glycogenolysis)	Alpha-1,4 glucan phosphorylase Calmodulin-like EF-hand domain-containing protein Glycogen debranching enzyme Glycogen phosphorylase, liver form Lysosomal alpha-glucosidase Phosphorylase b kinase gamma catalytic chain, liver/testis isoform Phosphorylase b kinase regulatory subunit Phosphorylase b kinase regulatory subunit glycogenin glucosyltransferase glycogenin glucosyltransferase	A0A3Q1LZJ1 A0A3Q1MR28 A0A3Q1N3K8 A0A3Q1NLJ5 F1MHT1 F1MJ28 F1MLH6 G3X778 Q0VCM4 Q2KJ16 Q9MYM4	AGL CALM GAA GYG1 GYG2 PHKA1 PHKA2 PHKG2 PYGL PYGM	Bos taurus (cattle)	G58161NS
Heme degradation	ABC-type glutathione-S-conjugate transporter Albumin Biliverdin reductase A Broad substrate specificity ATP-binding cassette transporter ABCG2 Fatty acid-binding protein, liver Flavin reductase (NADPH) Glutathione S-transferase A2 Glutathione S-transferase Glutathione S-transferase Glutathione S-transferase Heme oxygenase 1 Multidrug resistance-associated protein 1 Solute carrier organic anion transporter family member Solute carrier organic anion transporter family member UDP-glucuronosyltransferase heme oxygenase (biliverdin-producing)	A0A140T897 A0A3Q1M423 A0A3Q1MEC8 A0A3Q1MQ83 A0A3S5ZP51 B2D1N9 E1BKD8 F1MIP7 F1MTY9 F1MX44 F1MYV0 O18879 P52556 P80425 Q5E9F2 Q8HXQ5	ABCC1 ABCC2 ABCG2 ALB BLVRA BLVRB FABP1 GSTA1 GSTA2 GSTA5 HMOX1 HMOX2 MRP1 SCAN SLCO1B3 SLCO2B1 UGT1A6	Bos taurus (cattle)
Terminal pathway of complement	Clusterin Complement C5 Complement C7 Complement C8 alpha chain Complement component C8 beta chain Complement component C9	A0A3Q1LI40 F1MX87 F1MY85 F1N102 P17697 Q3MHN2	C5 C7 C8A C8B C9 CLU	Bos taurus (cattle)
Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)	Potassium channel subfamily K member 1 Potassium channel subfamily K member	E1B9M4 Q0P5A0	KCNK1 KCNK7	Bos taurus (cattle)
HS-GAG degradation	Agrin Alpha-L-iduronidase Beta-galactosidase Beta-galactosidase Beta-glucuronidase Galactosidase beta 1 like Glypican 2 Glypican 4 Glypican 5 Glypican-1 Glypican-3 Heparanase 2 (inactive) Heparanase Iduronate 2-sulfatase N-acetyl-alpha-glucosaminidase N-sulfoglucosamine sulfohydrolase Syndecan-1 Syndecan-2 Syndecan	A0A3Q1LN81 A0A3Q1LRF3 A0A3Q1LTY7 A0A3Q1LZ29 A0A3Q1NAQ3 A0A3Q1NDQ7 A3KMY8 E1BCP9 E1BFX4 E1BKJ2 E1BKS1 F1MCX1 F1MY73 F1MZX8 F1N1G1 F1N2D5 Q08DZ5 Q3ZBZ6 Q58DD4	AGRN GLB1 GLB1L GLB1L2 GPC1 GPC2 GPC3 GPC4 GPC5 GUSB HPSE HPSE2 IDS IDUA NAGLU SDC1 SDC2 SDC4 SGSH	Bos taurus (cattle)	G01550VL G09546QO
Degradation of the extracellular matrix	72 kDa type IV collagenase A disintegrin and metalloproteinase with thrombospondin motifs 4 ADAM metallopeptidase domain 15 ADAM metallopeptidase with thrombospondin type 1 motif 5 Aggrecan core protein Basigin Brevican core protein CD44 antigen Cadherin-1 Calpain 10 Calpain 12 Calpain 13 Calpain 14 Calpain 5 Calpain 6 Calpain 7 Calpain 8 Calpain small subunit 1 Calpain-1 catalytic subunit Calpain-2 catalytic subunit Calpain-3 Calpastatin Cathepsin K Cathepsin S Collagenase 3 Decorin Disintegrin and metalloproteinase domain-containing protein 10 Elastase, neutrophil expressed HtrA serine peptidase 1 Kallikrein-related peptidase 7 Matrix metallopeptidase 12 Matrix metallopeptidase 19 Matrix metallopeptidase 7 Matrix metallopeptidase 8 Matrix metalloproteinase-14 Matrix metalloproteinase-9 NID1 protein Opticin Peptidase S1 domain-containing protein Procathepsin L Secreted phosphoprotein 1 Signal peptide, CUB domain and EGF like domain containing 1 Signal peptide, CUB domain and EGF like domain containing 3 Stromelysin-1 Transmembrane serine protease 6 interstitial collagenase	A0A3Q1LJS3 A0A3Q1LZU0 A0A3Q1M4A6 A0A3Q1MG91 A0A3Q1MSS6 A0A3Q1MZC5 A0A452DI93 A0A452DJ01 A6QNS6 A6QP82 E1BAD2 E1BI66 E1BIX3 E1BJ18 E1BKJ3 F1MB09 F1MBN8 F1MJF1 F1MKH8 F1MQ31 F1MQD1 F1MQT9 F1MRZ2 F1MT97 F1MTX6 F1MU56 F1MW26 F1MWW8 F1N121 F1N1E3 F1N368 F6RFP6 G3MWP1 G3N0J0 G8JKX1 P13135 P21793 P25326 P25975 P52176 P58874 Q08D90 Q08DI9 Q10741 Q27971 Q5E968	ACAN ADAM10 ADAM15 ADAMTS4 ADAMTS5 BCAN BSG CAPN1 CAPN10 CAPN12 CAPN13 CAPN14 CAPN2 CAPN3 CAPN4 CAPN5 CAPN6 CAPN7 CAPN8 CAPNS1 CAST CD44 CDH1 CTSK CTSL CTSL1 CTSS DCN ELANE HTRA1 KLK7 LOC112441463 LOC509956 MADM MMP12 MMP13 MMP14 MMP19 MMP2 MMP3 MMP7 MMP8 MMP9 NID1 OPT OPTC SCUBE1 SCUBE3 SPP1 TMPRSS6	Bos taurus (cattle)
P2Y receptors	G protein-coupled receptor 17 LPAR4 protein Lysophosphatidic acid receptor 6 P2Y purinoceptor 14 P2Y purinoceptor 1 P2Y purinoceptor 2 P2Y purinoceptor 4 P2Y receptor family member 10 Purinergic receptor P2Y, G-protein coupled, 12 Purinergic receptor P2Y11 Pyrimidinergic receptor P2Y6	A2VEA2 A4IFV1 A6QL49 F1MDI7 F1MDW9 F1MTB2 F1MU50 G3X6Q0 P48042 Q0IIL0 Q3SX17	GPR17 LPAR4 LPAR6 P2RY1 P2RY10 P2RY11 P2RY12 P2RY14 P2RY2 P2RY4 P2RY5 P2RY6	Bos taurus (cattle)
NTF3 activates NTRK3 signaling	Neurotrophin-3 Tyrosine-protein kinase receptor	G3N3T6 Q08DT3	NTF3 NTRK3	Bos taurus (cattle)
Stimuli-sensing channels	Acid sensing ion channel subunit 1 Acid sensing ion channel subunit family member 4 Acid sensing ion channel subunit family member 5 Amiloride-sensitive cation channel 1, neuronal Amiloride-sensitive sodium channel subunit alpha Amiloride-sensitive sodium channel subunit beta Amiloride-sensitive sodium channel subunit gamma Anoctamin-4 Anoctamin Anoctamin Anoctamin Anoctamin Anoctamin Anoctamin Anoctamin Aspartyl/asparaginyl beta-hydroxylase Bestrophin-2 Bestrophin Bestrophin Bestrophin Calcium-activated chloride channel regulator 1 Calmodulin-like Chloride channel accessory 4 Chloride channel protein 2 Chloride channel protein Chloride channel protein Chloride channel protein Chloride intracellular channel 2 Chloride voltage-gated channel 1 EF-hand domain-containing protein H(+)/Cl(-) exchange transporter 7 Osteoclastosis associated transmembrane protein 1 Peptidyl-prolyl cis-trans isomerase FKBP1B Protein tweety homolog Protein tweety homolog Protein tweety homolog Ryanodine receptor 2 STOM protein Sodium channel epithelial 1 subunit delta Sodium leak channel, non-selective Solute carrier family 17 (Sodium phosphate), member 3 Solute carrier family 9 member B2 Solute carrier family 9, subfamily B (cation proton antiporter 2), member 1 Sorcin Stomatin like 3 Two pore segment channel 1 Two pore segment channel 2 Unc-79 homolog, NALCN channel complex subunit Unc-80 homolog, NALCN channel complex subunit Uncharacterized protein	A0A3Q1LL71 A0A3Q1LNC2 A0A3Q1LUZ5 A0A3Q1M2M7 A0A3Q1M2Y5 A0A3Q1MHC3 A0A3Q1MQ38 A0A3Q1MR28 A0A3Q1MUE0 A0A3Q1N2G9 A1A4I7 A2VE46 A5D7U4 A6QLE6 A6QNR5 A7YWH0 A8E4P3 E1B792 E1BF86 E1BF90 E1BFC4 E1BFF1 E1BHV1 E1BJF8 E1BK15 E1BLQ0 E1BMN1 F1MCB3 F1MFR7 F1MGK7 F1MGZ5 F1MJ95 F1MJW3 F1MLH6 F1MN45 F1MPC2 F1MTH0 F1MX70 F1MY57 F1N0S4 F6QQY9 G3N0G4 G3N3A9 P55270 P68107 Q0VC38 Q17QE9 Q28056 Q3SYU0 Q4PKH3	ACCN1 ANO10 ANO2 ANO3 ANO4 ANO5 ANO6 ANO8 ANO9 ASIC1 ASIC2 ASIC4 ASIC5 ASPH BEST1 BEST2 BEST3 BEST4 CALM CLCA1 CLCA4 CLCN1 CLCN2 CLCN3 CLCN5 CLCN6 CLCN7 CLCNKA CLIC2 FKBP12.6 FKBP1B NALCN NHEDC1 OSTM1 RYR2 SCNN1A SCNN1B SCNN1D SCNN1G SLC17A3 SLC9B2 SRI STOM STOML3 TMEM16D TPCN1 TPCN2 TTYH1 TTYH2 TTYH3 UNC79 UNC80	Bos taurus (cattle)
Nuclear events mediated by NFE2L2	5'-AMP-activated protein kinase catalytic subunit alpha-2 NFE2 like bZIP transcription factor 2 histone acetyltransferase histone acetyltransferase	A0A3Q1LRK0 E1B8D6 F1MD32 F1MQV7	CREBBP EP300 NFE2L2 PRKAA2	Bos taurus (cattle)
RHOA GTPase cycle	A-kinase anchoring protein 13 ABCD3 protein Actin, alpha cardiac muscle 1 Active breakpoint cluster region-related protein Acyl-CoA-binding domain-containing protein 5 Aladin WD repeat nucleoporin Anillin, actin binding protein ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 B-cell receptor-associated protein BCR activator of RhoGEF and GTPase Caveolae associated protein 1 Caveolin-1 Coiled-coil domain-containing protein 115 Complement component 1 Q subcomponent-binding protein, mitochondrial DDRGK domain-containing protein 1 DEP domain containing 1B Dedicator of cytokinesis 2 Delta(14)-sterol reductase LBR Diaphanous related formin 1 Diaphanous related formin 3 Dishevelled associated activator of morphosis 1 ER membrane protein complex subunit 3 Endoplasmic reticulum protein 27 FAS-associated factor 2 FERM, ARHGEF and pleckstrin domain-containing protein 1 Family with sequence similarity 13 member A Flotillin-1 Flotillin-2 Formin like 3 GMIP protein IQ motif containing GTPase activating protein 1 IQGAP3 protein Junction plakoglobin Kinectin 1 Lectin, mannose binding 1 MCF.2 cell line derived transforming sequence like MCF.2 cell line derived transforming sequence Melanoma cell adhesion molecule Myosin IXB Neuroepithelial cell transforming 1 Neuronal guanine nucleotide exchange factor Oligophrenin-1 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 Phospholipase Pleckstrin homology and RhoGEF domain containing G3 Pleckstrin homology and RhoGEF domain containing G5 Pleckstrin homology and RhoGEF domain containing G6 Progesterone receptor membrane component 2 Proto-oncogene vav Protocadherin 7 Rac GTPase activating protein 1 Ras protein specific guanine nucleotide releasing factor 2 Rho GDP-dissociation inhibitor 1 Rho GTPase activating protein 18 Rho GTPase activating protein 19 Rho GTPase activating protein 1 Rho GTPase activating protein 20 Rho GTPase activating protein 22 Rho GTPase activating protein 23 Rho GTPase activating protein 24 Rho GTPase activating protein 28 Rho GTPase activating protein 30 Rho GTPase activating protein 31 Rho GTPase activating protein 32 Rho GTPase activating protein 39 Rho GTPase activating protein 42 Rho GTPase activating protein 44 Rho GTPase activating protein 45 Rho GTPase activating protein 4 Rho GTPase activating protein 5 Rho GTPase activating protein 6 Rho GTPase activating protein 8 Rho GTPase activating protein 9 Rho GTPase-activating protein 10 Rho GTPase-activating protein 26 Rho GTPase-activating protein 29 Rho GTPase-activating protein 35 Rho GTPase-activating protein 7 Rho guanine nucleotide exchange factor 10 like Rho guanine nucleotide exchange factor 10 Rho guanine nucleotide exchange factor 11 Rho guanine nucleotide exchange factor 12 Rho guanine nucleotide exchange factor 15 Rho guanine nucleotide exchange factor 17 Rho guanine nucleotide exchange factor 19 Rho guanine nucleotide exchange factor 1 Rho guanine nucleotide exchange factor 25 Rho guanine nucleotide exchange factor 28 Rho guanine nucleotide exchange factor 2 Rho guanine nucleotide exchange factor 3 Rho guanine nucleotide exchange factor 5 Rho guanine nucleotide exchange factor 7 Rho-GAP domain-containing protein Rho-associated protein kinase Rho/Rac guanine nucleotide exchange factor 18 Rhophilin-2 Rhotekin SLIT-ROBO Rho GTPase activating protein 1 STOM protein Sec1 family domain containing 1 Serine/threonine-protein kinase N1 StAR related lipid transfer domain containing 13 StAR related lipid transfer domain containing 8 Starch binding domain 1 Synaptobrevin homolog YKT6 Synaptosomal-associated protein Syntaxin-5 T-cell activation GTPase activating protein TMEM87A protein Testis expressed 2 Tight junction protein 2 Transferrin receptor protein 1 Transforming protein RhoA V-type proton ATPase subunit S1 Vang-like protein Vav guanine nucleotide exchange factor 2 Vav guanine nucleotide exchange factor 3 Vesicle-associated membrane protein-associated protein B heme oxygenase (biliverdin-producing) non-specific serine/threonine protein kinase non-specific serine/threonine protein kinase non-specific serine/threonine protein kinase protein kinase C protein kinase C	A0A3Q1LFQ5 A0A3Q1LGT5 A0A3Q1LHF1 A0A3Q1LKT3 A0A3Q1LM61 A0A3Q1LNB6 A0A3Q1LNE2 A0A3Q1LQ45 A0A3Q1LUD9 A0A3Q1LUW4 A0A3Q1LVS2 A0A3Q1LWV5 A0A3Q1LWX5 A0A3Q1LX25 A0A3Q1M2Q1 A0A3Q1M4A0 A0A3Q1M4M7 A0A3Q1M851 A0A3Q1M8D9 A0A3Q1MA88 A0A3Q1MAP3 A0A3Q1MD11 A0A3Q1MEH9 A0A3Q1MFP5 A0A3Q1MN47 A0A3Q1MPX1 A0A3Q1MQP9 A0A3Q1MRV3 A0A3Q1MSA1 A0A3Q1MT43 A0A3Q1MW77 A0A3Q1N5A2 A0A3Q1N6F4 A0A3Q1N6J8 A0A452DIS6 A0A452DJ82 A1A4I4 A2VDZ9 A4FUC9 A4FV18 A4FV22 A6H7H0 A6QLR4 A6QNS3 A6QQV8 A7YY57 A7Z038 A8E4P3 E1B718 E1B801 E1B9G8 E1BAJ4 E1BBA0 E1BBD2 E1BCC1 E1BCK4 E1BDL7 E1BDY4 E1BG76 E1BH05 E1BH51 E1BHQ9 E1BI70 E1BIG6 E1BIM3 E1BJP2 E1BLB3 E1BM23 E1BMN2 E1BNE7 E1BNR7 E1BNV7 E1BP14 E1BQ24 F1MBM9 F1MBT6 F1MC48 F1MCL8 F1MCN4 F1MEK6 F1MF50 F1MFA5 F1MFC6 F1MFK1 F1MFS4 F1MGB9 F1MHI2 F1MIZ6 F1MJA6 F1MJH8 F1MK36 F1MLS2 F1MM72 F1MPJ6 F1MS34 F1MTN6 F1MTY9 F1MWY5 F1MYQ4 F1N1Q7 F1N2G5 F1N6V1 F1N7Q8 F6QCG0 F6QJJ8 F6RWK1 G3N2T3 G3X696 G5E6T2 P23726 P23727 P40682 P61585 P79132 Q08DA6 Q08DB1 Q08DB5 Q08DN7 Q08DN8 Q08DP6 Q2HJD0 Q2T9M8 Q3SZB5 Q3T000 Q3T0B6 Q3ZC07 Q3ZCB8 Q5E9F1 Q8SPJ1	AAAS ABCD3 ABR ACBD5 ACTC ACTC1 AKAP13 ANLN ARAP1 ARAP2 ARAP3 ARHA ARHGAP1 ARHGAP10 ARHGAP11A ARHGAP18 ARHGAP19 ARHGAP20 ARHGAP22 ARHGAP23 ARHGAP24 ARHGAP26 ARHGAP28 ARHGAP29 ARHGAP30 ARHGAP31 ARHGAP32 ARHGAP35 ARHGAP39 ARHGAP4 ARHGAP42 ARHGAP44 ARHGAP45 ARHGAP5 ARHGAP6 ARHGAP8 ARHGAP9 ARHGDIA ARHGEF1 ARHGEF10 ARHGEF10L ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF18 ARHGEF19 ARHGEF2 ARHGEF25 ARHGEF28 ARHGEF3 ARHGEF5 ARHGEF7 ATP6AP1 ATP6IP1 ATP6S1 BCAP31 BCR C1QBP CAV1 CAVIN1 CCDC115 DAAM1 DDRGK1 DEPDC1B DIAPH1 DIAPH3 DLC1 DOCK2 EMC3 ERP27 FAF2 FAM13A FARP1 FLOT1 FLOT2 FMNL3 GMIP HMOX2 IQGAP1 IQGAP3 JUP KTN1 LBR LMAN1 MCAM MCF2L MYO9B NET1 NGEF OPHN1 PCDH7 PGRMC2 PIK3R1 PIK3R2 PKN PKN1 PKN2 PKN3 PLD1 PLEKHG3 PLEKHG5 PLEKHG6 PREX1 PREX2 PRK1 PRKCL1 RACGAP1 RASGRF2 RHO12 RHOA RHPN2 ROCK1 ROCK2 RTKN SCFD1 SLK SNAP23 SRGAP1 STARD13 STARD8 STBD1 STOM STX5 TAGAP TEX2 TFRC TJP2 TMEM111 TMEM87A TRIO UBXD8 VANGL1 VAPB VAV1 VAV2 VAV3 YKT6	Bos taurus (cattle)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	ABC-type antigen peptide transporter Aminopeptidase Beta-2-microglobulin Calnexin Calreticulin Endoplasmic reticulum aminopeptidase 2 Endoplasmic reticulum chaperone BiP Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Protein SEC13 homolog Protein disulfide-isomerase Protein transport protein SEC23 Protein transport protein Sec24A Protein transport protein Sec31A SEC24 homolog B, COPII coat complex component SEC24 homolog C, COPII coat complex component SEC24 homolog D, COPII coat complex component Small COPII coat GTPase SAR1B Tapasin Transporter 1, ATP binding cassette subfamily B member	A0A3Q1LRW6 A0A3Q1MD45 A5D7E8 A5D7J6 A6QNT8 A6QPT7 A7Z066 E1BI37 E1BIU0 E1BJS0 E1BMP2 E1BPR4 F1MU34 F1MV07 F1MVW5 F1MVY8 F1MZQ5 F1N4Y5 P01888 Q0VCX2 Q2NL04 Q3T0T7 Q3ZCC9	B2M BOLA BOLA-NC1 CALR CANX ERAP1 ERAP2 GRP78 HSPA5 PDIA3 SAR1B SEC13 SEC13L1 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A TAP1 TAP2 TAPBP canx	Bos taurus (cattle)
PI3K Cascade	FLT3LG protein Fibroblast growth factor 1 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GRB2 associated binding protein 2 GRB2-associated-binding protein 1 Growth factor receptor-bound protein 2 Insulin receptor substrate 1 Insulin receptor substrate 2 Klotho beta Klotho Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Toll-like receptor 9 Tyrosine-protein phosphatase non-receptor type non-specific serine/threonine protein kinase phosphatidylinositol-4,5-bisphosphate 3-kinase receptor protein-tyrosine kinase	A0A3Q1LQK4 A0A3Q1LRU7 A0A3Q1LUE0 A0A3Q1M3Q3 A0A3Q1M864 A0A3Q1MPT9 A0A3Q1NAV6 A0MTF4 A2VE24 A5H631 A6QLU3 A6QLW1 D8KXU9 E1B7I9 E1BAI2 E1BFP8 E1BGY3 E1BHC1 E1BJU2 E1BP37 F1MHC6 F1MJE0 F1MN51 F1MRU0 F1MYE0 F1MYM3 F1N339 F1N4S9 F1N6G8 F2Z4J0 G3MXR4 G3XGD3 P03968 P03969 P23726 P23727 P32871 Q3T0F9	AFGF FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF23 FGF3 FGF4 FGF4A FGF4C FGF5 FGF5B FGF5C FGF6 FGF6A FGF7 FGF7B FGF8 FGF8A FGF9 FGFA FGFR1 FGFR2 FGFR3 FGFR4 FLT3 FLT3LG FRS2 Fgf4 GAB1 GAB2 GRB2 HBGF-1 IRS1 IRS2 KL KLB PIK3C3 PIK3CA PIK3CB PIK3R1 PIK3R2 PIK3R4 PTPN11 TLR9	Bos taurus (cattle)
Integrin cell surface interactions	Basigin CD44 antigen Cadherin-1 Cartilage oligomeric matrix protein Collagen alpha-1(IV) chain Collagen type IV alpha 3 chain Collagen type XIII alpha 1 chain Collagen type XVI alpha 1 chain Collagen type XVIII alpha 1 chain Fibrillin-1 Fibronectin Integrin alpha-3 Integrin alpha-L Integrin beta-2 Integrin beta-6 Integrin beta Integrin beta Integrin beta Integrin beta Integrin beta Integrin subunit alpha 10 Integrin subunit alpha 11 Integrin subunit alpha 1 Integrin subunit alpha 2 Integrin subunit alpha 2b Integrin subunit alpha 4 Integrin subunit alpha 6 Integrin subunit alpha 9 Integrin subunit alpha M Integrin subunit alpha V Integrin-binding sialoprotein Intercellular adhesion molecule 1 Intercellular adhesion molecule 3 Intercellular adhesion molecule 5 Intercellular adhesion molecule N-terminal domain-containing protein JAM2 protein Junctional adhesion molecule A Leukocyte surface antigen CD47 Lumican Platelet and endothelial cell adhesion molecule 1 Purinergic receptor P2X 5 Secreted phosphoprotein 1 Tenascin C Thrombospondin 1 VCAM1 protein VWFA domain-containing protein Vitronectin	A0A140T8D2 A0A3Q1LT76 A0A3Q1LZT3 A0A3Q1LZU0 A0A3Q1M8K4 A0A3Q1MFX6 A0A3Q1MHJ9 A0A3Q1MQV3 A0A3Q1MSS6 A0A3Q1MXS2 A4IFI9 A7MBB0 E1BDD5 E1BFX5 E1BLR0 F1MBA3 F1MEF6 F1MGZ4 F1MI38 F1MMH2 F1MMN6 F1MMS9 F1MQF0 F1MQT9 F1MRZ6 F1MTN1 F1MVW3 F1MZU6 F1N157 F1N6W9 F6RFP6 F6RKH9 F6RND5 G3MXK9 G3MYD9 G5E5A9 P32592 P35445 P61625 P98133 Q05443 Q28862 Q3ZBS7 Q7SIB2 Q8SQB8 Q8SQB9 Q9XT56	BSG CD18 CD44 CD47 CDH1 COL13A1 COL16A1 COL18A1 COL4A1 COL4A3 COMP F11R FBN1 FN1 IBSP ICAM1 ICAM3 ICAM5 ITGA1 ITGA10 ITGA11 ITGA2 ITGA2B ITGA3 ITGA4 ITGA6 ITGA9 ITGAL ITGAM ITGAV ITGAX ITGB1 ITGB2 ITGB3 ITGB5 ITGB6 ITGB7 ITGB8 JAM1 JAM2 LDC LOC534578 LOC616254 LUM P2RX5 PECAM1 SPP1 THBS1 TNC VCAM1 VTN	Bos taurus (cattle)
GDP-fucose biosynthesis	Fucose kinase Fucose-1-phosphate guanylyltransferase GDP-L-fucose synthase GDP-fucose transporter 1 GDP-mannose 4,6-dehydratase	A0A3Q1M2A1 A0A3Q1M4E5 A6QM03 E1B9U5 Q3ZBY8	FCSK FPGT FUCT1 GFUS GMDS SLC35C1	Bos taurus (cattle)	G85196CF G96881BQ
Phospholipase C-mediated cascade; FGFR2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma Fibroblast growth factor 1 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor	A0A3Q1LRU7 A0A3Q1M3Q3 A0A3Q1NAV6 A0MTF4 D8KXU9 E1BGY3 E1BHC1 E1BJU2 E1BP37 F1MHC6 F1MYF9 F1N6G8 F2Z4J0 G3MXR4 G3XGD3 P03968 P03969	AFGF FGF1 FGF10 FGF16 FGF17 FGF18 FGF2 FGF20 FGF23 FGF3 FGF4 FGF4A FGF4C FGF5 FGF5B FGF5C FGF6 FGF6A FGF7 FGF7B FGF8 FGF9 FGFA FGFR2 Fgf4 HBGF-1 PLCG1	Bos taurus (cattle)

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