GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	November 12, 2024
ECODAB	April 1, 2019

Displaying entries **101 - 125** of **361** in total

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Pathway Name	Protein Name ▼	UniProt ID	Gene Symbol	Organism	GlyTouCan ID
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	Erythropoietin receptor Erythropoietin GRB2 associated binding protein 1 Insulin receptor substrate 2 Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 2 Phosphoinositide 3-kinase regulatory subunit 5 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase	A0A286ZR76 A0A287B726 A0A5K1UB41 A0A5K1UPW2 A0A8X9AEI7 F1RT53 F1SKR9 I3LJB7 K7GMT0 O19064 P49157 Q9MYZ9	EPO EPOR GAB1 IRS2 JAK2 LYN PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R5	Sus scrofa (pig)
Interleukin-4 and Interleukin-13 signaling	Endoplasmin Interleukin 13 receptor subunit alpha 1 Interleukin 13 receptor subunit alpha 2 Interleukin 2 receptor gamma Interleukin-13 Interleukin-4 receptor subunit alpha Interleukin-4 Signal transducer and activator of transcription 3 Signal transducer and activator of transcription Signal transducer and activator of transcription Signal transducer and activator of transcription Suppressor of cytokine signaling 1 Suppressor of cytokine signaling 5 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase	A0A286ZLI2 A0A286ZN85 A0A287AFA5 A0A2C9F3G4 E5F1H4 E5F1H9 E7CR04 F1RFF9 F1RU78 F1RWT5 F1S3L9 K7GSE8 O19064 Q04745 Q19S50 Q76KD0 Q95J68	HSP90B1 IL13 IL13RA1 IL13RA2 IL2RG IL4 IL4R JAK1 JAK2 JAK3 SOCS1 SOCS5 STAT1 STAT3 STAT6 TYK2 socs1	Sus scrofa (pig)
Elastic fibre formation	Elastin Fibrillin 2 Fibrillin 3 Fibulin-5 Lysyl oxidase homolog Lysyl oxidase homolog Lysyl oxidase homolog Microfibril associated protein 2 Microfibril associated protein 5 furin protein-lysine 6-oxidase protein-lysine 6-oxidase	A0A287AM88 A0A287AXU0 A0A5G2QM06 A0A5G2QNS3 A0A5G2R2Y0 F1RLC4 F1RMJ1 F1S8X0 F1SD87 F1SIC9 F1SNV7 I3LI73	ELN FBLN5 FBN2 FBN3 FURIN LOX LOXL1 LOXL2 LOXL3 LOXL4 MFAP2 MFAP5	Sus scrofa (pig)
Vitamin B2 (riboflavin) metabolism	Ectonucleotide pyrophosphatase/phosphodiesterase 1 FAD synthase Riboflavin transporter Riboflavin transporter Tartrate-resistant acid phosphatase type 5 riboflavin kinase	A0A287AT99 A0A480TEK5 A0A5G2RJ73 F1RSN6 F1S866 P09889	ACP5 ENPP1 FLAD1 RFK SLC52A2 SLC52A3	Sus scrofa (pig)
Toll Like Receptor 9 (TLR9) Cascade	Early endosome antigen 1 Phosphatidylinositol 3-kinase catalytic subunit type 3 Rabenosyn, RAB effector Toll-like receptor 9 non-specific serine/threonine protein kinase	A0A287AVI7 A0A287BHR8 A0A5G2RJ76 F1SAI0 Q5I2M3	EEA1 PIK3C3 PIK3R4 RBSN TLR9	Sus scrofa (pig)
Negative regulation of FGFR4 signaling	E3 ubiquitin-protein ligase CBL Fibroblast growth factor 23 Fibroblast growth factor 9 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Growth factor receptor bound protein 2 Klotho beta Mitogen-activated protein kinase Mitogen-activated protein kinase Multifunctional fusion protein Polyubiquitin-C Tyrosine-protein phosphatase non-receptor type Ubiquitin B Ubiquitin C Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A0A286ZQE1 A0A287AFX3 A0A287AXR0 A0A287AZA7 A0A287B3V5 A0A287BGK8 A0A2C9F3G2 A0A480LMF4 A0A480NH74 A0A5G2QUY7 A0A5G2R7G2 A0A5G2RG05 A7U5U2 B6E241 F1RM38 F1RY80 F1S3B8 F1S911 F1SET9 I3L560 I3LR27 P0CG68 Q95L12	CBL FGF1 FGF16 FGF18 FGF19 FGF2 FGF20 FGF23 FGF4 FGF6 FGF8 FGF9 FGFR4 Fgf4 GRB2 KLB MAPK1 MAPK3 PTPN11 RPS27A UBA52 UBB UBC	Sus scrofa (pig)
Negative regulation of MET activity	E3 ubiquitin-protein ligase CBL Endophilin-A2 Epidermal growth factor receptor pathway substrate 15 Growth factor receptor bound protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor-regulated tyrosine kinase substrate Hepatocyte growth factor Leucine rich repeats and immunoglobulin like domains 1 Polyubiquitin-C SH3 domain containing GRB2 like 3, endophilin A3 SH3 domain containing kinase binding protein 1 Signal transducing adaptor molecule 2 Signal transducing adaptor molecule Tyrosine-protein phosphatase non-receptor type Tyrosine-protein phosphatase non-receptor type Ubiquitin B Ubiquitin C Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein ubiquitinyl hydrolase 1	A0A286ZQE1 A0A287A000 A0A287AZA7 A0A287BAQ6 A0A287BNZ9 A0A2C9F3G2 A0A5G2Q9Y0 A0A5G2QFX7 A0A5G2RE13 A7U5U2 B6E241 F1RYL9 F1S7L8 F1S911 F1SB93 F1SFR8 F1SHW8 I3LPZ5 P0CG68 Q2QLE0	CBL EPS15 GRB2 HGF HGS LRIG1 MET PTPN1 PTPN2 RPS27A SH3GL1 SH3GL3 SH3KBP1 STAM STAM2 UBA52 UBB UBC USP8	Sus scrofa (pig)
Regulation of IFNG signaling	E3 SUMO-protein ligase PIAS1 isoform 2 Interferon gamma receptor 1 Interferon gamma receptor 2 Interferon gamma Signal transducer and activator of transcription Small ubiquitin-related modifier 1 Suppressor of cytokine signaling 1 Suppressor of cytokine signaling 3 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type	A0A286ZLI2 A0A286ZN85 A0A287B963 A0A287BNZ9 A7WLH8 E5EZY0 E7CR04 F1S692 I3LJA1 O19064 P17803	IFNG IFNGR1 IFNGR2 JAK1 JAK2 PIAS1 PTPN2 SOCS1 SOCS3 STAT1 SUMO1 socs1	Sus scrofa (pig)
TGF-beta receptor signaling activates SMADs	E2 NEDD8-conjugating enzyme E3 ubiquitin-protein ligase CBL Integrin beta Integrin beta Integrin beta Integrin beta Integrin beta Integrin subunit alpha 8 Integrin subunit alpha V Latent transforming growth factor beta binding protein 1 Latent transforming growth factor beta binding protein 3 Latent transforming growth factor beta binding protein 4 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 4 Mothers against decapentaplegic homolog NEDD8 Serine/threonine-protein kinase receptor TGF-beta receptor type-1 Transforming growth factor beta receptor 3 Transforming growth factor beta-1 proprotein Transforming growth factor beta-3 proprotein Transforming growth factor beta-3 proprotein Transforming growth factor beta Zinc finger FYVE domain-containing protein furin peptidylprolyl isomerase	A0A286ZQE1 A0A286ZV08 A0A286ZWQ1 A0A287AE63 A0A287AZ66 A0A287BE69 A0A287BIH5 A0A287BIQ9 A0A287BLR9 A0A287BNE4 A0A287BPI7 A0A5G2R7K7 A0A5G2RC56 A0A5K1V6L8 A0A8W4FF41 A9X6R3 F1RMJ1 F1RRJ9 F1RW86 K7GQ83 K7GSJ9 P07200 P15203 P84024 Q2VTP6 Q9GKQ9	CBL FKBP1A FURIN ITGA8 ITGAV ITGB1 ITGB3 ITGB5 ITGB6 ITGB8 LTBP1 LTBP3 LTBP4 MADH3 MADH4 NEDD8 SMAD2 SMAD3 SMAD4 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3 UBE2M ZFYVE9	Sus scrofa (pig)
Thyroxine biosynthesis	Dual oxidase 1 Glycoprotein hormones alpha chain Iodotyrosine deiodinase 1 NAD(P)H oxidase (H2O2-forming) NAD(P)H oxidase (H2O2-forming) Sodium iodide symporter Thyroid peroxidase Thyrotropin subunit beta	A0A287AZ10 A0A287B129 A0A287BQ51 K7GR01 P01219 P01224 Q8HZK3 Q9GJX7	CGA DUOX1 DUOX2 IYD SLC5A5 TPO TSHB	Sus scrofa (pig)
Mitochondrial unfolded protein response (UPRmt)	DnaJ homolog subfamily A member 1 Estrogen receptor Forkhead box O3 Heat shock 70 kDa protein 1B Heat shock factor protein 1 Sirtuin 3 Uncharacterized protein	A0A287BQU9 A0A5G2R1I1 F1RSM7 F1RT23 F1SE73 Q29040 Q6S4N2	DNAJA1 ESR ESR1 FOXO3 HSF1 HSPA1B NR3A1 SIRT3	Sus scrofa (pig)
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	Dipeptidyl peptidase 4 G protein-coupled receptor 119 Gastric inhibitory polypeptide	F1RTG3 I3LI45 P22411	CD26 DPP4 GIP GPR119	Sus scrofa (pig)
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	Dipeptidyl peptidase 4 Free fatty acid receptor 4 G protein subunit beta 3 G protein-coupled receptor 119 Gastrin-releasing peptide Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Leptin Pro-glucagon	A0A287AW90 E7EDN1 F1RTG3 F1SLU8 P01274 P22411 P63153 Q29406	CD26 DPP4 FFAR4 GCG GNB1 GNB3 GPR119 GPR120 GRP LEP O3FAR1 OB OBS	Sus scrofa (pig)	G58161NS
FMO oxidises nucleophiles	Dimethylaniline monooxygenase [N-oxide-forming] 3 Flavin-containing monooxygenase 1 Flavin-containing monooxygenase	F1S6B6 I3LS94 P16549	FMO-1 FMO1 FMO2 FMO3	Sus scrofa (pig)
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	DEK proto-onco Transcription factor AP-2-alpha	A0A287B9K7 A0A5G2QII0	DEK TFAP2A	Sus scrofa (pig)
Vitamin C (ascorbate) metabolism	Cytochrome b5 Glutathione S-transferase omega-1 NADH-cytochrome b5 reductase Solute carrier family 2, facilitated glucose transporter member 1 Solute carrier family 2, facilitated glucose transporter member 3 Solute carrier family 23 member 1	A0A5G2QPB6 I3LCS3 O62787 P00172 P20303 Q9N1F5	CYB5 CYB5A CYB5R3 GLUT1 GLUT3 GSTO1 SLC23A1 SLC2A1 SLC2A3	Sus scrofa (pig)
Activation of the phototransduction cascade	Cyclic nucleotide gated channel subunit beta 1 Cyclic nucleotide-gated channel alpha-1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Phosphodiesterase Rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma Rhodopsin	A0A287AW90 A0A5G2R841 A0A8W4FII8 F1RF40 F1RL89 O18766	CNGA1 CNGB1 GNB1 PDE6A PDE6G RHO RHO1	Sus scrofa (pig)
Prolactin receptor signaling	Cullin 1 Growth hormone 1 Prolactin receptor Prolactin S-phase kinase-associated protein 1 SH2B adaptor protein 1 Somatotropin Tyrosine-protein kinase JAK2 cullin-RING-type E3 NEDD8 transferase	A0A286ZMM6 A0A287ARU4 A0A287B501 A0A5S6I4D7 F1RFI0 O19064 P01238 P01248 Q6JTA8	CUL1 GH1 JAK2 PRL PRLR RBX1 SH2B1 SKP1	Sus scrofa (pig)
RUNX3 regulates p14-ARF	Core-binding factor subunit beta G1/S-specific cyclin-D1 Histone deacetylase Runt-related transcription factor Transforming growth factor beta-1 proprotein histone acetyltransferase	A0A287BQF9 A0A287BRJ4 A0A5G2QVF3 A0A5G2R2L4 I3L9U8 P07200	CBFB CCND1 EP300 HDAC4 RUNX3 TGFB1	Sus scrofa (pig)
RUNX1 regulates estrogen receptor mediated transcription	Core-binding factor subunit beta Estrogen receptor Runt-related transcription factor	A0A5G2R2L4 F8SIP5 Q29040	CBFB ESR ESR1 NR3A1 RUNX1	Sus scrofa (pig)
Inactivation of CSF3 (G-CSF) signaling	Colony stimulating factor 3 receptor Granulocyte colony-stimulating factor Granulocyte colony-stimulating factor Tyrosine-protein kinase JAK2 Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase	A0A286ZLI2 A0A287BSA9 A0A5G2QVW3 A0A5G2QXL6 F1RT53 F1S3L9 O02837 O19064	CSF3 CSF3R HCK JAK1 JAK2 LYN TYK2	Sus scrofa (pig)
Other interleukin signaling	Colony stimulating factor 3 receptor Granulocyte colony-stimulating factor Granulocyte colony-stimulating factor Interferon lambda receptor 1 Interferon lambda-1 Interleukin 34 Interleukin-10 receptor subunit beta Macrophage colony-stimulating factor 1 Pro-interleukin-16 Syndecan Syntaxin 3 Syntaxin 4 Syntaxin-1A Syntaxin-binding protein 2 T-cell surface glycoprotein CD4 Taxilin alpha Tyrosine-protein kinase Tyrosine-protein kinase Vesicle-associated membrane protein 2 protein-tyrosine-phosphatase receptor protein-tyrosine kinase	A0A286ZLI2 A0A286ZQU5 A0A286ZTU8 A0A286ZYA3 A0A287A6Q8 A0A287A948 A0A287BPE2 A0A287BQK7 A0A288CFU1 A0A5G2QA44 A0A5G2QIU0 A0A5G2QVW3 A0A5G2QXL6 A0A5G2R276 A0A8W4FDM0 F1RGA3 F1RIR2 F1S3L9 I3L556 K7GNF5 O02837	CD4 CSF1 CSF1R CSF3 CSF3R IFNLR1 IL10RB IL16 IL29 IL34 JAK1 PTPRZ1 SDC1 STX1A STX3 STX4 STXBP2 TXLNA TYK2 VAMP2	Sus scrofa (pig)
Signaling by CSF3 (G-CSF)	Colony stimulating factor 3 receptor GRB2 associated binding protein 2 Granulocyte colony-stimulating factor Granulocyte colony-stimulating factor Growth factor receptor bound protein 2 SHC-transforming protein 1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type small monomeric GTPase	A0A286ZLI2 A0A287B630 A0A287BSA9 A0A480LMF4 A0A5G2QVW3 A0A5G2QXL6 A0A5K1V5Y3 B6E241 F1RT53 F1S3L9 I3LCQ9 O02837 O19064	CSF3 CSF3R GAB2 GRB2 HCK JAK1 JAK2 KRAS LYN PTPN11 SHC1 TYK2	Sus scrofa (pig)
Interleukin receptor SHC signaling	Colony stimulating factor 2 receptor subunit beta Fibronectin type-III domain-containing protein GRB2 associated binding protein 2 Granulocyte-macrophage colony-stimulating factor Growth factor receptor bound protein 2 Interleukin 2 receptor gamma Interleukin 5 receptor subunit alpha Interleukin-2 receptor subunit alpha Interleukin-2 receptor subunit beta Interleukin-2 Interleukin-5 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 2 Phosphatidylinositol 3-kinase regulatory subunit beta SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase Tyrosine-protein kinase phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase	A0A286ZLI2 A0A286ZUQ0 A0A287A7A4 A0A287ABR0 A0A287AFR0 A0A287B630 A0A287BFJ1 A0A5G2QEJ3 A0A5G2RAE7 A0A5K1UB41 A0A5K1UPW2 A0A5K1V5Y3 A0A8X9AEI7 B6E241 F1S916 F1SFL9 F1SKR9 K7GSE8 O19064 P26891 Q29118 Q76KD0 Q9MYM5	CSF2 CSF2RA CSF2RB GAB2 GRB2 IL2 IL2RA IL2RB IL2RG IL5 IL5RA INPP5D INPPL1 JAK1 JAK2 JAK3 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 SHC1 SOS1	Sus scrofa (pig)
Lectin pathway of complement activation	Collectin subfamily member 10 Collectin-11 Ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) Ficolin (collagen/fibrinogen domain containing) 1 MBL associated serine protease 1 MBL associated serine protease 2 Mannose-binding protein C	A0A287ATF0 A0A5G2QE59 A0A5G2QFX9 A0A5G2QP75 A0A8W4FNY0 I3LEW0 K7GKU8	COLEC10 COLEC11 FCN1 FCN2 MASP1 MASP2 MBL2	Sus scrofa (pig)	G49108TO G57321FI

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