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MIRAGE
EGFR downregulation

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
CBLEGF-like ligands:p-6Y-EGFR:CBLEGF-like ligands:p-6Y EGFR dimerATPEGF-like ligands:p-6Y-EGFR:p-Y371-CBLADPUbEGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2SPRY1/2EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBLCBL:GRB2Ash-LEGF-like ligands:p-6Y-EGFR:CBL:GRB2EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2p-Y55-SPRY2CBL:SPRY1/2CBL:Beta-Pix:CDC42:GTPBeta-Pix:CDC42:GTPEGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:EndophilinEGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTPCIN85:endophilinUb-Beta-Pix:CDC42:GTPEps15REGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15EPN1EPS15:HGS:STAMEGF:Phospho-EGFR dimer:CBL:Phospho-SproutyEGF-like ligands:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15L1:Eps15SPRY1/2EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15H2OPiEGF:p-6Y-EGFR dimerEGF:p-EGFR dimer dephosphorylated at Y1172 (Y1148)EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAMPIP2EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".
a simple tooltip
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025