Oxidative Stress Induced Senescence

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4ADPATPCDKN2A Gene:H3K27Me3-Nucleosomep-PRC1.4 complexUbp-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53PolyUb-TP53 Tetramerp14ARF mRNAp14ARFp14ARFMINK1/TNIK genesMINK1/TNIKSEK1p-S257,T261-SEK1ATPADPEED GeneEEDEZH2 GeneEZH2 Gene:E2F1/2/3:DP1/2E2F1/2/3:DP1/2EZH2SUZ12 GeneSUZ12SAMCDKN2A Gene:NucleosomeSAHCDKN2A geneKDM6B Genep-2S-cJUN:p-2S,2T-cFOS:KDM6B Genep-2S-cJUN:p-2S,2T-cFOSFe2+KDM6B:Fe2+KDM6Bp16INK4A mRNAphospho-p38 MAPK:p-T-182-MAPKAPK5phospho-p38 MAPK: MAPKAPK5p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4:TP53p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4TP53 TetramermiR-24 Nonendonucleolytic RISCp16INK4A/p14ARF mRNA: miR-24 Nonendonucleolytic RISCp16INK4A/p14ARF mRNACDK4,CDK6CDK4,CDK6:INK4INK4p-MAPK8,9,10p-MAPK8,9,10p-MKK3,p-MKK6p-MKK3,p-MKK6p38 MAPK:MAPKAPK2,3p-p38 MAPK: MAPKAPK2,3JUNp-S63,S73-JUNphosphorylated c-FOSROSADFMAP3K5:TXNASK1MKK3, MKK6EED Gene:E2F1/2/3:DP1/2SUZ12 Gene:E2F1/2/3:DP1/2PRC2 (EZH2) CoreRBBP7RBBP4PRC1.42OGSUCCAp38 MAPK:MAPKAPK5p-S37-TP53 TetramerMTS1MAPK8,9,10p-p38 MAPK:p-MAPKAPK2/3FOS
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying entries 1 - 10 of 55 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
O00257 E3 SUMO-protein ligase CBX4
  • CBX4
view
O15054 Lysine-specific demethylase 6B
  • JMJD3
  • KDM6B
  • KIAA0346
view
O60814 Histone H2B type 1-K
  • H2BC12
  • H2BFT
  • HIRIP1
  • HIST1H2BK
view
O95819 Mitogen-activated protein kinase kinase kinase kinase 4
  • HGK
  • KIAA0687
  • MAP4K4
  • NIK
view
P01100 Protein c-Fos
  • FOS
  • G0S7
view
P01574 Interferon beta
  • IFB
  • IFNB
  • IFNB1
view
P04637 Cellular tumor antigen p53
  • P53
  • TP53
view
P04908 Histone H2A type 1-B/E
  • H2AC4
  • H2AC8
  • H2AFA
  • H2AFM
  • HIST1H2AB
  • HIST1H2AE
view
P05412 Transcription factor Jun
  • JUN
view
P06899 Histone H2B type 1-J
  • H2BC11
  • H2BFR
  • HIST1H2BJ
view
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 4, 2025