Disassembly of the destruction complex and recruitment of AXIN to the membrane

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
GSK3BFRAT1,2:GSK3betaFRAT1,2p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complexbeta-catenin:destruction complexGSK3B:AXIN1WNT:FZD:LRP5/6:DVL:AXIN:GSK3BWNT:FZD:LRP5/6:DVLWNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3BATPADPWNT:FZD:p10S/T-LRP5/6:DVL:AXIN:GSK3BWNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1APC_HUMANCTNNB1PP2ACSNK1A1WTX
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
a simple tooltip

About Release Notes Help Feedback

Click here to visit the beta site.


International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


Logo License Policies Site Map

Contact: support@glycosmos.org

This work is licensed under Creative Commons Attribution 4.0 International


GlyCosmos Portal v4.2.1

Last updated: April 7, 2025