Synthesis of active ubiquitin: roles of E1 and E2 enzymes

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
UBBUBBUBB(77-152)UBB(153-228)ATPPPiUBA1:ubiquitin adenylateUBA1UbUBA6UBA6:ubiquitin adenylateATPPPiUbUBA1:ubiquitin adenylateUBA1Ub-Cys632-UBA1:ubiquitin adenylateUb-Cys632-UBA1UBCUBC(457-532)UBC(229-304)UBC(153-228)UBC(77-152)UBCUBC(381-456)UBC(305-380)UBC(533-608)UBC(609-684)RL40_HUMANRPL40UBA52RPS27ARPS27ARPS27A(77-156)Ub-Cys632-UBA1AMPUb-Cys632-UBA1:ubiquitin adenylateE2 ubiquitin conjugating enzyme (UBA1 substrate)Ub:E2 (UBA1 substrate)Ub-Cys625-UBA6Ub-Cys625-UBA6:ubiquitin adenylateUb:E2 (UBA6 substrate)E2 ubiquitin conjugating enzyme (UBA6 substrate)AMPUb:E2 (UBA1 substrate)E2 ubiquitin conjugating enzyme (UBA1 substrate)
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025