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MIRAGE
TICAM1-dependent activation of IRF3/IRF7

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
viral dsRNA:TLR3:TRIFTRAF3:TRIF:activated TLR3TRAF3K63polyUb-TRAF3:TRIF:activated TLR3UbTANKTANK:K63-poly-Ub-TRAF3:TRIF:activated TLR3K63pUb-TANK:K63pUb-TRAF3:TRIF:activated TLR3IKKEIKBKE:K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNAATPp-S172-IKBKE:K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNAADPTBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3TBK1p-S172-TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKEactivated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7IRF3,IRF7phosphorylated IRF3/IRF7phosphorylated IRF3 and/or IRF7 dimerphosphorylated IRF3 and/or IRF7 dimer
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
Displaying all 6 entries
UniProt ID Protein Name Gene Symbol Pathway Viewer
O15455 Toll-like receptor 3
  • TLR3
 view
P62979 Ubiquitin-ribosomal protein eS31 fusion protein
  • RPS27A
  • UBA80
  • UBCEP1
 view
P62987 Ubiquitin-ribosomal protein eL40 fusion protein
  • UBA52
  • UBCEP2
 view
Q92844 TRAF family member-associated NF-kappa-B activator
  • ITRAF
  • TANK
  • TRAF2
 view
Q92985 Interferon regulatory factor 7
  • IRF7
 view
Q96CV9 Optineurin
  • FIP2
  • GLC1E
  • HIP7
  • HYPL
  • NRP
  • OPTN
 view
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025