Degradation of the extracellular matrix

Summary
Species
Mus musculus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
BsgBSG:MMP1(100-469)Q9EPL5ElastinCleaved elastinFibrillin 1,2,(3)Cleaved fibrillin 1,2,(3)Fibrillin-1Cleaved fibrillin-1Fibronectin matrixCleaved fibronectin matrixCleaved fibronectin matrix Ala(271)/Val(272)Nid1Nid1Nid1H2OACAN(17-375)ACANACAN(376-2415)BcanBcanBcanBcanBcanDcnDcnDcnCDH1(155-882):Ca2+ dimerE-cadherin strand dimer fragment 701-882E-cadherin strand dimer fragment 155-700MMP1, 3, 13, (2, 7-12, 19)Alpha 2-macroglobulin:MMP1, 3, 13, (2, 7-12, 19)A2M tetramerCD44CD44:MMP2, MMP7, MMP9MMP2, MMP7, MMP9Spp1Spp1Spp1substrate protein for calpainscalpain-cleaved proteinOptcOptcOptcOptcOptcOptcOptcScube3Scube3Scube3SCUBE1,SCUBE3SCUBE1,SCUBE3 polymer, SCUBE3 polymer
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying entries 1 - 10 of 31 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
O35598 Disintegrin and metalloproteinase domain-containing protein 10
  • Adam10
  • Kuz
  • Madm
view
O70138 Neutrophil collagenase
  • Mmp8
view
O70370 Cathepsin S
  • Cats
  • Ctss
view
O88839 Disintegrin and metalloproteinase domain-containing protein 15
  • Adam15
  • Mdc15
view
P06797 Procathepsin L
  • Ctsl
  • Ctsl1
view
P09803 Cadherin-1
  • Cdh1
view
P10493 Nidogen-1
  • Ent
  • Nid1
view
P10923 Osteopontin
  • Eta-1
  • Op
  • Spp-1
  • Spp1
view
P15379 CD44 antigen
  • Cd44
  • Ly-24
view
P18572 Basigin
  • Bsg
view
Displaying all 3 entries
GlyCosmos Lectin UniProt ID Lectin Name Pathway Viewer
GL_000048 Q61282 Aggrecan core protein view
GL_000111 Q61361 Brevican core protein view
GL_004623 P18572 Basigin view
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025