Signaling by ALK

Summary
Species
Mus musculus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
ALKALK dimer:ALKAL2:(ALKAL1)ALKAL2:(ALKAL1)ligand-bound ALK dimerActive ALK dimerATPADPtype I ALK-binding TKIsALK dimer:ligand:type I ALK binding TKIActive ALK:IRS1Irs1Active ALK:pY-IRS1Active ALK:SHC1Shc1Active ALK:p-3Y SHC1PI3KActive ALK:PI3KPIP2PIP3Active ALK:PLCG1PLCG1Active ALK:p-4Y PLCG1Active ALK:JAK3JAK3Active ALK:p-Y980 JAK3H2OPiP42227Stat3p-Y705,S727-STAT3 dimerp-Y705,S727-STAT3 dimer
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025