GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **1 - 25** of **250** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism	GlyTouCan ID
Transport of RCbl within the body	Oligomycin resistance ATP-dependent permease YOR1	P53049	YOR1 YRS1	Saccharomyces cerevisiae (brewer's yeast)
RNA Polymerase I Promoter Escape	Cyclin CCL1 DNA-directed RNA polymerase I subunit RPA12 DNA-directed RNA polymerase I subunit RPA135 DNA-directed RNA polymerase I subunit RPA190 DNA-directed RNA polymerase I subunit RPA43 DNA-directed RNA polymerase I subunit RPA49 DNA-directed RNA polymerases I and III subunit RPAC1 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2 General transcription and DNA repair factor IIH subunit SSL1 General transcription and DNA repair factor IIH subunit TFB1 General transcription and DNA repair factor IIH subunit TFB2 General transcription and DNA repair factor IIH subunit TFB4 General transcription and DNA repair factor IIH subunit TFB5 Histone H2A.1 Histone H2A.2 Histone H2A.Z Histone H2B.1 Histone H2B.2 Histone H3-like centromeric protein CSE4 Histone H3 Histone H4 RNA polymerase I-specific transcription initiation factor RRN3 RNA polymerase I-specific transcription initiation factor RRN7 RNA polymerase II transcription factor B subunit 3 Serine/threonine-protein kinase KIN28 TATA-box-binding protein	P02293 P02294 P02309 P04911 P04912 P06242 P06839 P07703 P10964 P13393 P20434 P20435 P20436 P22138 P22139 P32529 P32776 P36012 P36070 P37366 P40422 P40992 P46669 P61830 Q00578 Q01080 Q02939 Q03290 Q04673 Q12004 Q12692 Q3E7C1	BTF1 CCL1 CSE4 CSL2 H2A1 H2A2 H2AZ H2B1 H2B2 HHF1 HHF2 HHT1 HHT2 HTA1 HTA2 HTA3 HTB1 HTB2 HTZ1 KIN28 LOM3 RAD25 RAD3 REM1 RIG2 RPA1 RPA12 RPA135 RPA190 RPA2 RPA43 RPA49 RPA7 RPB10 RPB12 RPB5 RPB6 RPB8 RPC10 RPC40 RPC5 RPC9 RPO26 RRN1 RRN12 RRN13 RRN2 RRN3 RRN4 RRN7 SIN2 SPT11 SPT12 SPT15 SRP3 SSL1 SSL2 TBP1 TFB1 TFB2 TFB3 TFB4 TFB5 UVS112	Saccharomyces cerevisiae (brewer's yeast)
DNA replication initiation	DNA polymerase alpha catalytic subunit A DNA polymerase alpha subunit B DNA polymerase epsilon catalytic subunit A DNA polymerase epsilon subunit B DNA polymerase epsilon subunit C DNA polymerase epsilon subunit D DNA primase large subunit DNA primase small subunit Protein DLS1	P10363 P13382 P20457 P21951 P24482 P27344 P38121 P40366 Q04603	CDC17 DLS1 DPB2 DPB3 DPB4 DUN2 POL1 POL12 POL2 PRI1 PRI2	Saccharomyces cerevisiae (brewer's yeast)
HSF1 activation	ATP-dependent molecular chaperone HSC82 ATP-dependent molecular chaperone HSP82 Cell division control protein 48 Co-chaperone protein SBA1 Elongation factor 1 alpha-like protein Elongation factor 1-alpha Heat shock transcription factor Histone deacetylase HDA1 Protein BMH2	P02829 P02994 P10961 P15108 P25694 P28707 P32769 P34730 P53973	BMH2 CDC48 HBS1 HDA1 HSC82 HSF1 HSP82 HSP90 SBA1 TEF1 TEF2	Saccharomyces cerevisiae (brewer's yeast)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	Kexin	P13134	KEX2 QDS1	Saccharomyces cerevisiae (brewer's yeast)
Transport of vitamins, nucleosides, and related molecules	Uncharacterized membrane protein YBR220C	P38318	YBR220C	Saccharomyces cerevisiae (brewer's yeast)
Hydrolysis of LPE	Lysophospholipase 1 Lysophospholipase 2 Lysophospholipase 3 Putative meiotic phospholipase SPO1	P39105 P53541 Q03674 Q08108	PLB1 PLB2 PLB3 SPO1	Saccharomyces cerevisiae (brewer's yeast)
DNA Damage/Telomere Stress Induced Senescence	DNA repair protein RAD50 Double-strand break repair protein MRE11 Histone acetyltransferase ESA1 Serine/threonine-protein kinase TEL1	P12753 P32829 P38110 Q08649	ESA1 MRE11 RAD50 TEL1	Saccharomyces cerevisiae (brewer's yeast)
Regulation of HSF1-mediated heat shock response	Endoplasmic reticulum chaperone BiP Heat shock protein SSA1 Heat shock protein SSA2 Heat shock protein SSA3 Heat shock protein SSA4 Heat shock protein homolog SSE1 Heat shock protein homolog SSE2 Heat shock transcription factor Import motor subunit, mitochondrial Mitogen-activated protein kinase FUS3 Mitogen-activated protein kinase KSS1 Mitogen-activated protein kinase SLT2/MPK1 Nucleoporin ASM4 Nucleoporin NDC1 Nucleoporin NIC96 Nucleoporin NSP1 Nucleoporin NUP116/NSP116 Nucleoporin NUP120 Nucleoporin NUP133 Nucleoporin NUP170 Nucleoporin NUP188 Nucleoporin NUP192 Nucleoporin NUP1 Nucleoporin NUP2 Nucleoporin NUP42 Nucleoporin NUP57 Nucleoporin NUP82 Nucleoporin NUP84 Nucleoporin NUP85 Nucleoporin SEH1 Protein BMH2 Protein MLP1 Protein OPI10 Protein kinase MCK1 Protein transport protein SEC13 Ran-specific GTPase-activating protein 1 Ran-specific GTPase-activating protein 2 Ribosome-associated molecular chaperone SSB1 Ribosome-associated molecular chaperone SSB2 Serine/threonine-protein kinase MRK1 Serine/threonine-protein kinase RIM11/MSD1 Sporulation-specific mitogen-activated protein kinase SMK1 Zuotin mRNA export factor GLE2	P09435 P0CS90 P10591 P10592 P10961 P11484 P14681 P14907 P16474 P16892 P20676 P21965 P22202 P32499 P32500 P32527 P32589 P32590 P34077 P34730 P35729 P36161 P38181 P38615 P40066 P40150 P40368 P40517 P41808 P41920 P46673 P47054 P48837 P49686 P50873 P52593 P52891 P53011 Q00772 Q02455 Q02630 Q04491 Q05166 Q08202	ANU3 ASM4 BMH2 CST20 DAC2 ENS1 FUS3 GLE2 GRP78 GSK3 HSF1 HSP HTN1 KAR2 KSS1 MCK1 MDS1 MLP1 MPK1 MRK1 MSI3 NDC1 NIC96 NLE3 NSP1 NSP116 NUP1 NUP116 NUP120 NUP133 NUP170 NUP188 NUP192 NUP2 NUP42 NUP57 NUP59 NUP82 NUP84 NUP85 OPI10 RAE1 RAT2 RAT3 RAT9 RIM11 RIP1 SEC13 SEH1 SFO1 SLT2 SMK1 SSA1 SSA2 SSA3 SSA4 SSB1 SSB2 SSC1 SSD1 SSE1 SSE2 UIP1 YG101 YG103 YPK1 YRB1 YRB2 ZUO1	Saccharomyces cerevisiae (brewer's yeast)
CDC42 GTPase cycle	Actin cytoskeleton-regulatory complex protein END3 Actin cytoskeleton-regulatory complex protein PAN1 Cell division control protein 42 EH domain-containing and endocytosis protein 1 GTPase-activating protein BEM2/IPL2 GTPase-activating protein BEM3 GTPase-activating protein SAC7 Guanine nucleotide-binding protein alpha-1 subunit Increased rDNA silencing protein 4 Nuclear fusion protein FUS2 Protein ECM25 RHO GTPase-activating protein RGD1 Rho GDP-dissociation inhibitor Rho-GTPase-activating protein BAG7 Rho-type GTPase-activating protein 1 Rho-type GTPase-activating protein 2 Uncharacterized protein YHR182W	P08539 P17121 P19073 P32521 P32525 P32873 P34216 P36115 P38339 P38870 P39013 P39083 P39960 Q05670 Q06407 Q12128 Q12434	BAG7 BEM2 BEM3 BUD15 CDC42 CDC70 DAC1 DBM1 DIM2 ECM25 EDE1 END3 FUS2 GPA1 IPL2 IRS4 MDP3 MIP3 PAN1 RDI1 RGA1 RGA2 RGD1 SAC7 SCG1 SRO2 SUP9 THE1 YHR182W	Saccharomyces cerevisiae (brewer's yeast)
Glycerophospholipid catabolism	Ectonucleotide pyrophosphatase/phosphodiesterase 1 Ectonucleotide pyrophosphatase/phosphodiesterase 2 Lysophospholipase NTE1	P25353 P39997 Q04958	NPP1 NPP2 NTE1	Saccharomyces cerevisiae (brewer's yeast)
Linoleic acid (LA) metabolism	Fatty acid elongase 1 Fatty acid elongase 2 Fatty acid elongase 3 Peroxisomal long-chain fatty acid import protein 2	P25358 P39540 P40319 P41909	APA1 ELO1 ELO2 ELO3 FEN1 GNS1 PAL1 PAT2 PXA1 SRE1 SSH2 SUR4 VBM1 VBM2	Saccharomyces cerevisiae (brewer's yeast)
Vitamin C (ascorbate) metabolism	Cytochrome b5 NADH-cytochrome b5 reductase 1 Probable metabolite transport protein YBR241C Vacuolar protein sorting-associated protein 73	P38142 P38626 P40312 P53142	CBR CBR1 CBR5 CYB5 VPS73 YBR241C	Saccharomyces cerevisiae (brewer's yeast)
Translation initiation complex formation	ATP-dependent RNA helicase eIF4A Eukaryotic initiation factor 4F subunit p150 Eukaryotic translation initiation factor 1A Eukaryotic translation initiation factor 2 subunit alpha Eukaryotic translation initiation factor 2 subunit beta Eukaryotic translation initiation factor 2 subunit gamma Eukaryotic translation initiation factor 3 subunit A Eukaryotic translation initiation factor 3 subunit B Eukaryotic translation initiation factor 3 subunit C Eukaryotic translation initiation factor 3 subunit G Eukaryotic translation initiation factor 3 subunit I Eukaryotic translation initiation factor 3 subunit J Eukaryotic translation initiation factor 4B Eukaryotic translation initiation factor 4E Nucleolar protein 13 Protein PES4 Small ribosomal subunit protein eS10A Small ribosomal subunit protein eS10B Small ribosomal subunit protein eS12 Small ribosomal subunit protein eS17A Small ribosomal subunit protein eS17B Small ribosomal subunit protein eS19A Small ribosomal subunit protein eS1B Small ribosomal subunit protein eS21B Small ribosomal subunit protein eS24A Small ribosomal subunit protein eS24B Small ribosomal subunit protein eS25A Small ribosomal subunit protein eS26A Small ribosomal subunit protein eS27A Small ribosomal subunit protein eS27B Small ribosomal subunit protein eS28B Small ribosomal subunit protein eS4A Small ribosomal subunit protein eS4B Small ribosomal subunit protein eS6A Small ribosomal subunit protein eS6B Small ribosomal subunit protein eS7A Small ribosomal subunit protein eS8A Small ribosomal subunit protein eS8B Small ribosomal subunit protein uS10 Small ribosomal subunit protein uS11B Small ribosomal subunit protein uS12A Small ribosomal subunit protein uS12B Small ribosomal subunit protein uS13A Small ribosomal subunit protein uS13B Small ribosomal subunit protein uS14A Small ribosomal subunit protein uS15 Small ribosomal subunit protein uS17A Small ribosomal subunit protein uS17B Small ribosomal subunit protein uS19 Small ribosomal subunit protein uS2A Small ribosomal subunit protein uS3 Small ribosomal subunit protein uS4A Small ribosomal subunit protein uS4B Small ribosomal subunit protein uS5 Small ribosomal subunit protein uS7 Small ribosomal subunit protein uS8A Small ribosomal subunit protein uS9A Small ribosomal subunit protein uS9B Ubiquitin-ribosomal protein eS31 fusion protein	O13516 P02407 P05750 P05755 P05756 P05759 P06103 P07260 P07280 P09064 P0C0W1 P0C0X0 P0CX29 P0CX30 P0CX31 P0CX32 P0CX35 P0CX36 P0CX37 P0CX38 P0CX39 P0CX40 P0CX47 P0CX48 P0CX51 P0CX52 P0CX55 P0CX56 P10081 P14127 P20459 P23248 P25443 P26783 P26786 P32481 P32497 P32905 P34167 P35997 P38249 P38701 P38711 P38912 P39516 P39684 P39935 P39938 P40217 P41057 P46784 P48589 P53883 Q01855 Q04067 Q05775 Q08745 Q3E754 Q3E792	CDC33 CDC63 CRY2 GCD11 HCR1 NAB1 NAB1A NIP1 NOP13 PES4 PLC2 PRT1 RP51A RP51B RP55A RP61R RPG1 RPS0A RPS101 RPS102 RPS10A RPS10B RPS11A RPS11B RPS12 RPS13 RPS13A RPS13B RPS13C RPS14A RPS14B RPS15 RPS16A RPS16AA RPS16B RPS17A RPS17B RPS18A RPS18B RPS19A RPS1B RPS2 RPS20 RPS21 RPS21B RPS22A RPS23A RPS23B RPS24 RPS24A RPS24B RPS24EA RPS24EB RPS25A RPS25B RPS26 RPS26A RPS26B RPS27A RPS27B RPS28A RPS28B RPS29A RPS3 RPS30 RPS31 RPS31A RPS33B RPS36A RPS37 RPS4 RPS4A RPS4B RPS5 RPS6A RPS6B RPS7A RPS7B RPS8A RPS8B RPS9A RPS9B STM1 SUF14 SUI2 SUI3 SUI4 SUP38 SUP44 SUP46 TIF1 TIF11 TIF2 TIF211 TIF212 TIF213 TIF3 TIF32 TIF34 TIF35 TIF41A TIF41B TIF42 TIF45 TIF4631 UBI3 URP2 YS11A YS29A YST1	Saccharomyces cerevisiae (brewer's yeast)
RNA Polymerase II Transcription Initiation And Promoter Clearance	Cyclin CCL1 DNA-directed RNA polymerase II subunit RPB11 DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB3 DNA-directed RNA polymerase II subunit RPB4 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit RPB9 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2 General transcription and DNA repair factor IIH subunit SSL1 General transcription and DNA repair factor IIH subunit TFB1 General transcription and DNA repair factor IIH subunit TFB2 General transcription and DNA repair factor IIH subunit TFB4 General transcription and DNA repair factor IIH subunit TFB5 Protein SPT3 RNA polymerase II transcription factor B subunit 3 Serine/threonine-protein kinase KIN28 TATA-box-binding protein Transcription initiation factor IIA large subunit Transcription initiation factor IIA subunit 2 Transcription initiation factor IIB Transcription initiation factor IIE subunit alpha Transcription initiation factor IIE subunit beta Transcription initiation factor IIF subunit alpha Transcription initiation factor IIF subunit beta Transcription initiation factor TFIID subunit 10 Transcription initiation factor TFIID subunit 11 Transcription initiation factor TFIID subunit 12 Transcription initiation factor TFIID subunit 13 Transcription initiation factor TFIID subunit 1 Transcription initiation factor TFIID subunit 2 Transcription initiation factor TFIID subunit 4 Transcription initiation factor TFIID subunit 5 Transcription initiation factor TFIID subunit 6 Transcription initiation factor TFIID subunit 7 Transcription initiation factor TFIID subunit 9	P04050 P06242 P06839 P06844 P08518 P11747 P13393 P16370 P20433 P20434 P20435 P20436 P22139 P23255 P27999 P29055 P32773 P32774 P32776 P34087 P36100 P36145 P37366 P38129 P38902 P40422 P41895 P41896 P46677 P50105 P53040 Q00578 Q02939 Q03290 Q03761 Q04226 Q04673 Q05021 Q05027 Q12004 Q12030 Q3E7C1	BTF1 CCL1 FUN81 KIN28 LOM3 MPT1 RAD25 RAD3 REM1 RIG2 RPA7 RPB1 RPB10 RPB11 RPB12 RPB150 RPB2 RPB220 RPB3 RPB4 RPB5 RPB6 RPB7 RPB8 RPB9 RPC10 RPC9 RPO21 RPO22 RPO26 SPT15 SPT3 SSL1 SSL2 SSU71 SUA7 SUA8 TAF1 TAF10 TAF11 TAF12 TAF13 TAF130 TAF145 TAF150 TAF17 TAF19 TAF2 TAF23 TAF25 TAF4 TAF40 TAF48 TAF5 TAF6 TAF60 TAF61 TAF67 TAF68 TAF7 TAF9 TAF90 TBP1 TFA1 TFA2 TFB1 TFB2 TFB3 TFB4 TFB5 TFG1 TFG2 TOA1 TOA2 TSG2 TSM1 UVS112	Saccharomyces cerevisiae (brewer's yeast)
Sodium/Proton exchangers	Endosomal/prevacuolar sodium/hydrogen exchanger	Q04121	NHA2 NHX1 VPL27 VPS44	Saccharomyces cerevisiae (brewer's yeast)
Glycolysis	ATP-dependent 6-phosphofructokinase subunit alpha ATP-dependent 6-phosphofructokinase subunit beta Enolase 1 Enolase 2 Enolase-related protein 1 Enolase-related protein 2 Enolase-related protein 3 Glucokinase-1 Glucose-6-phosphate isomerase Glyceraldehyde-3-phosphate dehydrogenase 1 Glyceraldehyde-3-phosphate dehydrogenase 2 Glyceraldehyde-3-phosphate dehydrogenase 3 Hexokinase-1 Hexokinase-2 N-acetylglucosamine kinase Phosphoglycerate kinase Phosphoribomutase Putative glucokinase-2 Pyruvate kinase 1 Pyruvate kinase 2 Triosephosphate isomerase	P00358 P00359 P00360 P00549 P00560 P00924 P00925 P00942 P04806 P04807 P0CX10 P0CX11 P12709 P16861 P16862 P17709 P42222 P52489 Q03262 Q04409 Q06204	CDC19 EMI2 ENO1 ENO2 ENOA ENOB ERR1 ERR2 ERR3 GLK1 GPD1 GPD2 GPD3 HEX1 HKA HKB HOR3 HSP48 HXK1 HXK2 NGK1 PFK1 PFK2 PGI1 PGK1 PGM3 PRM15 PYK1 PYK2 SSS2 TDH1 TDH2 TDH3 TPI1	Saccharomyces cerevisiae (brewer's yeast)	G58161NS
HDACs deacetylate histones	Chromatin assembly factor 1 subunit p50 Histone H2A.1 Histone H2A.2 Histone H2B.1 Histone H2B.2 Histone H3-like centromeric protein CSE4 Histone H4 Histone acetyltransferase type B subunit 2 Histone deacetylase HDA1 Histone deacetylase HOS1 Histone deacetylase RPD3 Probable DNA-binding protein SNT1 Probable histone deacetylase HOS2 SIR4-interacting protein SIF2 SWI/SNF chromatin-remodeling complex subunit SWI1 Transcriptional modulator WTM1 Transcriptional modulator WTM2 Transcriptional regulatory protein DEP1 Transcriptional regulatory protein SAP30 Transcriptional regulatory protein SDS3 Transcriptional regulatory protein UME1	P02293 P02294 P02309 P04911 P04912 P09547 P13712 P25357 P31385 P32561 P36012 P38262 P38429 P39984 P40505 P53096 P53973 Q03010 Q12206 Q12214 Q12363	ADR6 CAC3 CSE4 CSL2 DEP1 EMB1 FUN54 GAM3 H2A1 H2A2 H2B1 H2B2 HAT2 HDA1 HHF1 HHF2 HOS1 HOS2 HTA1 HTA2 HTB1 HTB2 MOF6 MSI1 REC3 RPD3 SAP30 SDI2 SDS3 SDS6 SIF2 SNT1 SPT11 SPT12 SWI1 UME1 WTM1 WTM2 WTM3	Saccharomyces cerevisiae (brewer's yeast)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	26S proteasome regulatory subunit 4 homolog 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B homolog 26S proteasome regulatory subunit 7 homolog 26S proteasome regulatory subunit 8 homolog 26S proteasome regulatory subunit RPN12 26S proteasome regulatory subunit RPN1 26S proteasome regulatory subunit RPN2 26S proteasome regulatory subunit RPN3 26S proteasome regulatory subunit RPN5 26S proteasome regulatory subunit RPN6 26S proteasome regulatory subunit RPN7 26S proteasome regulatory subunit RPN8 26S proteasome regulatory subunit RPN9 26S proteasome subunit RPT4 DNA damage response protein kinase DUN1 M-phase inducer phosphatase Polyubiquitin Probable 26S proteasome regulatory subunit p27 Probable proteasome subunit alpha type-7 Proteasome activator BLM10 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-7 Serine/threonine-protein kinase KSP1 Serine/threonine-protein kinase RCK1 Ubiquitin carboxyl-terminal hydrolase RPN11	P0CG63 P21242 P21243 P22141 P23638 P23639 P23748 P25043 P25451 P30656 P30657 P32379 P32496 P32565 P33297 P33298 P33299 P38622 P38624 P38691 P38764 P39009 P40016 P40302 P40303 P40327 P40555 P43583 P43588 P53549 Q01939 Q04062 Q06103 Q08723 Q12250 Q12377	BLM10 BLM3 CIM3 CIM5 CRL13 CRL3 DOA3 DOA5 DUN1 HRD2 KSP1 MIH1 MPR1 NAS1 NAS2 NAS4 NAS5 NAS7 NIN1 PCS1 PRC1 PRC2 PRE1 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE8 PRE9 PRG1 PRS1 PRS2 PRS4 PRS5 PUP1 PUP2 PUP3 RCK1 RPD1 RPN1 RPN11 RPN12 RPN2 RPN3 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 SCD2 SCL1 SEN3 SUG1 SUG2 SUN2 TBPY TBY1 UBI4 YHS4 YNT1 YTA1 YTA2 YTA3 YTA5	Saccharomyces cerevisiae (brewer's yeast)
RHOU GTPase cycle	Actin cytoskeleton-regulatory complex protein END3 Actin cytoskeleton-regulatory complex protein PAN1 Cell division control protein 42 Class E vacuolar protein-sorting machinery protein HSE1 Clathrin heavy chain E3 ubiquitin-protein ligase RSP5 EH domain-containing and endocytosis protein 1 GTP-binding protein RHO5 Increased rDNA silencing protein 4 LAS seventeen-binding protein 1 Myosin-2 Myosin-4 Ras GTPase-activating-like protein IQG1 Serine/threonine-protein kinase CLA4 Serine/threonine-protein kinase SKM1 Serine/threonine-protein kinase STE20 tRNA (34-2'-O)-methyltransferase regulator RTT10	P19073 P19524 P22137 P32492 P32521 P34216 P36115 P38753 P39013 P39940 P48562 P53281 P53879 Q03497 Q08924 Q12280 Q12469	BUD15 CDC42 CDC66 CHC1 CLA4 CYK1 DIM2 EDE1 END3 ERE2 HSE1 IQG1 IRS4 LSB1 MDP1 MDP3 MIP3 MYO2 MYO4 NPI1 PAN1 RHO5 RSP5 RTT10 SHE1 SKM1 SRO2 STE20 TRM734	Saccharomyces cerevisiae (brewer's yeast)
ERK/MAPK targets	Mitogen-activated protein kinase FUS3 Mitogen-activated protein kinase HOG1 Mitogen-activated protein kinase KSS1 Mitogen-activated protein kinase SLT2/MPK1 Protein phosphatase PP2A regulatory subunit A Serine/threonine-protein kinase YPK3 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase PP2A-1 catalytic subunit Sporulation-specific mitogen-activated protein kinase SMK1	P14681 P16892 P23594 P31383 P32485 P38070 P38903 P41808 Q00772	DAC2 FUS3 HOG1 KSS1 MPK1 PPH21 RTS1 SCS1 SLT2 SMK1 SSK3 TPD3 YPK3	Saccharomyces cerevisiae (brewer's yeast)
PI3K/AKT Signaling	Probable target of rapamycin complex 2 subunit BIT2 Serine/threonine-protein kinase PKH2 Serine/threonine-protein kinase SCH9 Serine/threonine-protein kinase TOR2 Serine/threonine-protein kinase YPK1 Target of rapamycin complex 2 subunit AVO1 Target of rapamycin complex 2 subunit BIT61 Target of rapamycin complex 2 subunit TSC11 Target of rapamycin complex subunit LST8	P11792 P12688 P32600 P38346 P40061 P41318 P47041 Q08236 Q12236	AVO1 AVO3 BIT2 BIT61 DRR2 KOM1 LST8 PKH2 SCH9 SLI2 TOR2 TSC11 TSC14 YPK1	Saccharomyces cerevisiae (brewer's yeast)
Metal ion SLC transporters	Copper transport protein CTR2 Vacuolar zinc transporter COT1 Vacuolar zinc transporter ZRC1	P20107 P32798 P38865	COT1 CTR2 ZRC1	Saccharomyces cerevisiae (brewer's yeast)
Glycosphingolipid catabolism	Ectonucleotide pyrophosphatase/phosphodiesterase 1 Ectonucleotide pyrophosphatase/phosphodiesterase 2 Inositol phosphosphingolipids phospholipase C	P25353 P39997 P40015	ISC1 NPP1 NPP2	Saccharomyces cerevisiae (brewer's yeast)
APAP ADME	ABC transporter ATP-binding protein/permease VMR1 ABC transporter NFT1 ATP-dependent bile acid permease Bile pigment transporter 1 Cys-Gly metallodipeptidase DUG1 Glutathione hydrolase proenzyme Metal resistance protein YCF1 Oligomycin resistance ATP-dependent permease YOR1 Probable ATP-dependent permease	P0CE68 P14772 P25371 P32386 P38735 P39109 P43616 P53049 Q05902	ADP1 BAT1 BPT1 CIS2 DUG1 ECM38 NFT1 VMR1 YBT1 YCF1 YOR1 YRS1	Saccharomyces cerevisiae (brewer's yeast)

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