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Niemann-Pick disease type A
Summary
- Definition
- A Niemann-Pick disease characterized by onset in infancy and involvement of neurological tissues that has_material_basis_in an autosomal recessive mutation of the SMPD1 gene on chromosome 11p15.4.
- Super Class
- Niemann-Pick disease
External Links
- Disease Ontology
- DOID:0070111
- Mondo Disease Ontology
- OMIM
- GARD
- WikiPathways (from TogoID)
Related Genes
Related Glycoprotein
| UniProt ID | Protein Name | Source |
|---|---|---|
| P04062 | Lysosomal acid glucosylceramidase | |
| P17405 | Sphingomyelin phosphodiesterase | |
| Q13231 | Chitotriosidase-1 |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0002205 | Recurrent respiratory infections |
| HP:0001249 | Intellectual disability |
| HP:0003593 | Infantile onset |
| HP:0001541 | Ascites |
| HP:0006579 | Prolonged neonatal jaundice |
| HP:0002013 | Vomiting |
| HP:0001265 | Hyporeflexia |
| HP:0002376 | Developmental regression |
| HP:0000007 | Autosomal recessive inheritance |
| HP:0002188 | Delayed CNS myelination |
