chronic obstructive pulmonary disease

Summary
Synonym
  • COLD
  • COPD
  • chronic obstructive airway disease
  • chronic obstructive lung disease
Definition
An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.
Super Class
obstructive lung disease
External Links
Disease Ontology
DOID:3083
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
OMIM
MGI genotype (from TogoID)
Related Genes
Displaying entries 1 - 10 of 136 in total
Gene ID Gene Symbol Description Source
43 ACHE acetylcholinesterase (Yt blood group)
47 ACLY ATP citrate lyase
142 PARP1 poly(ADP-ribose) polymerase 1
217 ALDH2 aldehyde dehydrogenase 2 family member
246 ALOX15 arachidonate 15-lipoxygenase
248 ALPI alkaline phosphatase, intestinal
250 ALPP alkaline phosphatase, placental
308 ANXA5 annexin A5
410 ARSA arylsulfatase A
411 ARSB arylsulfatase B
Displaying all 10 entries
Gene ID Gene Symbol Description Source
11450 Adipoq adiponectin, C1Q and collagen domain containing
11554 Adrb1 adrenergic receptor, beta 1
12654 Chi3l1 chitinase 3 like 1
15558 Htr2a 5-hydroxytryptamine (serotonin) receptor 2A
16846 Lep leptin
16847 Lepr leptin receptor
17082 Il1rl1 interleukin 1 receptor-like 1
19017 Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
21898 Tlr4 toll-like receptor 4
21926 Tnf tumor necrosis factor
Displaying all 9 entries
Gene ID Gene Symbol Description Source
24536 Lepr leptin receptor
24835 Tnf tumor necrosis factor
24925 Adrb1 adrenoceptor beta 1
25556 Il1rl1 interleukin 1 receptor-like 1
25608 Lep leptin
29260 Tlr4 toll-like receptor 4
29595 Htr2a 5-hydroxytryptamine receptor 2A
83516 Ppargc1a PPARG coactivator 1 alpha
89824 Chi3l1 chitinase 3 like 1
Displaying all 7 entries
Gene ID Gene Symbol Description Source
31926 Idgf4 Imaginal disc growth factor 4
34978 Idgf1 Imaginal disc growth factor 1
34979 Idgf2 Imaginal disc growth factor 2
34981 Idgf3 Imaginal disc growth factor 3
36868 Idgf6 Imaginal disc growth factor 6
37104 Idgf5 Imaginal disc growth factor 5
43222 Tl Toll
Displaying 1 entry
Gene ID Gene Symbol Description Source
180628 cht-1 putative endochitinase
Displaying 1 entry
Gene ID Gene Symbol Description Source
851977 CTS2 putative chitinase
Related Glycoprotein
Displaying entries 101 - 103 of 103 in total
UniProt ID Protein Name Source
Q9UEF7 Klotho
Q9UNK4 Group IID secretory phospholipase A2
Q9Y336 Sialic acid-binding Ig-like lectin 9

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024