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Standards Ontologies Notations
pulmonary fibrosis

Summary
Synonym
  • Fibrosis of lung
Definition
An interstitial lung disease that is characterized by destruction, scarring, and thickening of the interstitial lung tissues and progressive pulmonary function loss in a restrictive pattern, has_symptom progressive shortness of breath, fatigue, and chronic cough, possibly has_material_basis_in exposure to certain chemicals, autoimmune conditions, and radiation.
Super Class
interstitial lung disease
Disease Ontology
DOID:3770
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
MGI genotype (from TogoID)
WikiPathways (from TogoID)
Related Genes
Displaying entries 1 - 10 of 69 in total
Gene ID Gene Symbol Description Source
177 AGER advanced glycosylation end-product specific receptor
182 JAG1 jagged canonical Notch ligand 1
183 AGT angiotensinogen
240 ALOX5 arachidonate 5-lipoxygenase
301 ANXA1 annexin A1
572 BAD BCL2 associated agonist of cell death
623 BDKRB1 bradykinin receptor B1
627 BDNF brain derived neurotrophic factor
847 CAT catalase
948 CD36 CD36 molecule (CD36 blood group)
Displaying entries 31 - 40 of 56 in total
Gene ID Gene Symbol Description Source
16449 Jag1 jagged 1
17128 Smad4 SMAD family member 4
17195 Mbl2 mannose-binding lectin (protein C) 2
17395 Mmp9 matrix metallopeptidase 9
17833 Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric
18024 Nfe2l2 nuclear factor, erythroid derived 2, like 2
18049 Ngf nerve growth factor
18128 Notch1 notch 1
18595 Pdgfra platelet derived growth factor receptor, alpha polypeptide
19225 Ptgs2 prostaglandin-endoperoxide synthase 2
Displaying entries 21 - 30 of 42 in total
Gene ID Gene Symbol Description Source
59086 Tgfb1 transforming growth factor, beta 1
60582 Il1rn interleukin 1 receptor antagonist
63868 Hspd1 heat shock protein family D (Hsp60) member 1
64639 Bad BCL2-associated agonist of cell death
81509 Bdkrb1 bradykinin receptor B1
81687 Mmp9 matrix metallopeptidase 9
81810 Tgfbr2 transforming growth factor, beta receptor 2
83502 Cdh1 cadherin 1
83619 Nfe2l2 NFE2 like bZIP transcription factor 2
84352 Col1a2 collagen type I alpha 2 chain
Displaying entries 11 - 16 of 16 in total
Gene ID Gene Symbol Description Source
37455 Egfr Epidermal growth factor receptor
37892 mAChR-A muscarinic Acetylcholine Receptor, A-type
38868 Snmp2 Sensory neuron membrane protein 2
42514 Snmp1 Sensory neuron membrane protein 1
43275 Ser Serrate
251900 GlcAT-I Glucuronyltransferase I
Displaying all 8 entries
Gene ID Gene Symbol Description Source
30718 notch1a notch receptor 1a
58133 ngfb nerve growth factor b (beta polypeptide)
114424 cdh1 cadherin 1, type 1, E-cadherin (epithelial)
140421 jag1a jagged canonical Notch ligand 1a
386856 pdgfra platelet-derived growth factor receptor, alpha polypeptide
548607 b3gat1a beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) a
565980 ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
100332644 b3gat1b beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) b
Displaying all 6 entries
Gene ID Gene Symbol Description Source Organism
397778 tgfb1.L transforming growth factor beta 1 L homeolog Xenopus laevis (African clawed frog)
100037842 notch1 notch 1 receptor Xenopus tropicalis (tropical clawed frog)
100037907 b3gat1 beta-1,3-glucuronyltransferase 1 Xenopus tropicalis (tropical clawed frog)
100144634 ace angiotensin I converting enzyme Xenopus tropicalis (tropical clawed frog)
100337618 cdh1.S cadherin 1, type 1 S homeolog Xenopus laevis (African clawed frog)
108709389 ngf.S nerve growth factor S homeolog Xenopus laevis (African clawed frog)
Displaying entries 1 - 10 of 15 in total
Gene ID Gene Symbol Description Source
174462 let-23 Receptor tyrosine-protein kinase let-23;receptor protein-tyrosine kinase
174517 sqv-8 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase sqv-8
175182 ver-1 Protein ver-1
175383 zmp-2 Matrix metalloproteinase-B
175781 daf-4 Cell surface receptor daf-4;Serine/threonine-protein kinase receptor;receptor protein serine/threonine kinase
176286 glp-1 glp-1/Notch intracellular domain
177343 skn-1 BZIP domain-containing protein;Protein skinhead-1
178672 srp-3 Serpin domain-containing protein
179197 cri-2 Putative metalloproteinase inhibitor tag-225
179962 gar-3 Muscarinic acetylcholine receptor gar-3
Displaying all 2 entries
Gene ID Gene Symbol Description Source
851977 CTS2 putative chitinase
853177 APL6 Apl6p
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024