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jagged canonical Notch ligand 1a
Summary
- Gene Symbol
-
- jag1a
- Organism
- Danio rerio (zebrafish)
Annotation
- Keyword
-
- Calcium
- Cell membrane
- Developmental protein
- Disulfide bond
- EGF-like domain
- Glycoprotein
- Notch signaling pathway
- Reference proteome
- Repeat
- Signal
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| B8JKQ5 |
|
| A0A8M2BFK4 |
|
| Q90Y57 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| cell communication | ||
| regulation of non-canonical NF-kappaB signal transduction | ||
| animal organ development | ||
| positive regulation of hematopoietic stem cell differentiation | ||
| system development |
GO Hierarchy
biological process
biological regulation [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| calcium ion binding | ||
| receptor ligand activity | ||
| Notch binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Notch
- Functional Category
-
- G: Carbohydrate transport and metabolism
- M: Cell wall/membrane/envelope biogenesis
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| calcium ion binding |
| InterPro |
|---|
| EGF-like calcium-binding domain |
| EGF-like calcium-binding, conserved site |
| EGF-like domain |
| EGF-type aspartate/asparagine hydroxylation site |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:10595 | Charcot-Marie-Tooth disease | |
| DOID:12930 | dilated cardiomyopathy | |
| DOID:13375 | temporal arteritis | |
| DOID:1682 | congenital heart disease | |
| DOID:2377 | multiple sclerosis | |
| DOID:3770 | pulmonary fibrosis | |
| DOID:6419 | tetralogy of Fallot | |
| DOID:684 | hepatocellular carcinoma | |
| DOID:8398 | osteoarthritis | |
| DOID:9245 | Alagille syndrome |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 182 | HGNC:6188 | |||
| 16449 | MGI:1095416 | |||
| 29146 | RGD:2937 | |||
| 43275 | FB:FBgn0004197 | |||
| 100486874 | Xenbase:XB-GENE-485662 | |||
| 100693766 | 8128_0:0039ce | |||
| 101078728 | 31033_0:001121 | |||
| 101168394 | 8090_0:003701 | |||
| 101169088 | 8090_0:00047c | |||
| 102230170 | 8083_0:005189 |
