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MIRAGE
myelofibrosis
Summary
- Synonym
-
- Agnogenic myeloid metaplasia
- Aleukemic myelosis
- Megakaryocytic myelosclerosis
- bone Marrow Fibrosis
- myelosclerosis
- primary myelofibrosis
- Definition
- A myeloid neoplasm that is located in the bone marrow which results in bone marrow being replaced by fibrous (scar) tissue.
- Super Class
- myeloid neoplasm
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 811 | CALR | calreticulin | |
| 2146 | EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | |
| 3077 | HFE | homeostatic iron regulator | |
| 4297 | KMT2A | lysine methyltransferase 2A | |
| 4352 | MPL | MPL proto-oncogene, thrombopoietin receptor | |
| 171023 | ASXL1 | ASXL transcriptional regulator 1 |
Related Glycoprotein
| UniProt ID | Protein Name | Source |
|---|---|---|
| P27797 | Calreticulin | |
| P40238 | Thrombopoietin receptor | |
| Q03164 | Histone-lysine N-methyltransferase 2A | |
| Q15910 | Histone-lysine N-methyltransferase EZH2 | |
| Q30201 | Hereditary hemochromatosis protein | |
| Q8IXJ9 | Polycomb group protein ASXL1 |
| UniProt ID | Protein Name | Source |
|---|---|---|
| P06876 | Transcriptional activator Myb | |
| Q9WU42 | Nuclear receptor corepressor 2 |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000967 | Petechiae |
| HP:0000979 | Purpura |
| HP:0012143 | Abnormal megakaryocyte morphology |
| HP:0001028 | Hemangioma |
| HP:0005561 | Abnormal bone marrow cell morphology |
| HP:0001409 | Portal hypertension |
| HP:0012378 | Fatigue |
| HP:0001871 | Abnormality of blood and blood-forming tissues |
| HP:0004377 | Hematological neoplasm |
| HP:0001873 | Thrombocytopenia |
