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optineurin

Summary

Gene Symbol

OPTN

Organism

Homo sapiens (human)

External Links

NCBI Gene

10133

PubChem

10133

Alliance of Genome Resources

HGNC:17142

Annotation

Keyword

3D-structure
Alternative splicing
Amyotrophic lateral sclerosis
Autophagy
Coiled coil
Cytoplasm
Cytoplasmic vesicle
Disease variant
Endosome
Glaucoma
Golgi apparatus
Host-virus interaction
Innate immunity
Phosphoprotein
Reference proteome
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96CV9	E3-14.7K-interacting protein Huntingtin yeast partner L Huntingtin-interacting protein 7 Huntingtin-interacting protein L NEMO-related protein Optic neuropathy-inducing protein Transcription factor IIIA-interacting protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
autophagy	IEA
positive regulation of xenophagy	IMP	21617041
Golgi ribbon formation	IBA IDA IMP	15837803 27534431
protein localization to Golgi apparatus	IBA IMP	15837803
regulation of canonical NF-kappaB signal transduction	IBA

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

autophagy

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy

cellular process [inference]

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport [inference]

Golgi to plasma membrane transport [inference]

Golgi to plasma membrane protein transport

vesicle-mediated transport to the plasma membrane [inference]

Golgi to plasma membrane transport [inference]

Golgi to plasma membrane protein transport

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

vesicle-mediated transport to the plasma membrane [inference]

Golgi to plasma membrane transport [inference]

Golgi to plasma membrane protein transport

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to Golgi apparatus

establishment of protein localization [inference]

protein transport [inference]

Golgi to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

protein localization to cell periphery [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

response to mitochondrial depolarisation [inference]

regulation of autophagy of mitochondrion in response to mitochondrial depolarization [inference]

positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization [inference]

positive regulation of mitophagy in response to mitochondrial depolarization [inference]

parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

process utilizing autophagic mechanism [inference]

autophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

Golgi organization

Golgi ribbon formation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

innate immune response

cellular response to stress [inference]

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

response to mitochondrial depolarisation [inference]

regulation of autophagy of mitochondrion in response to mitochondrial depolarization [inference]

positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization [inference]

positive regulation of mitophagy in response to mitochondrial depolarization [inference]

parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

response to topologically incorrect protein [inference]

response to unfolded protein [inference]

cellular response to unfolded protein

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

innate immune response

response to chemical [inference]

response to organic substance [inference]

response to topologically incorrect protein [inference]

response to unfolded protein [inference]

cellular response to unfolded protein

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

cellular response to organic substance [inference]

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

response to mitochondrial depolarisation [inference]

regulation of autophagy of mitochondrion in response to mitochondrial depolarization [inference]

positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization [inference]

positive regulation of mitophagy in response to mitochondrial depolarization [inference]

parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to Golgi apparatus

establishment of protein localization [inference]

protein transport [inference]

Golgi to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

protein localization to cell periphery [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport [inference]

Golgi to plasma membrane transport [inference]

Golgi to plasma membrane protein transport

vesicle-mediated transport to the plasma membrane [inference]

Golgi to plasma membrane transport [inference]

Golgi to plasma membrane protein transport

organic substance transport [inference]

protein transport [inference]

Golgi to plasma membrane protein transport

nitrogen compound transport [inference]

protein transport [inference]

Golgi to plasma membrane protein transport

establishment of protein localization [inference]

protein transport [inference]

Golgi to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

vesicle-mediated transport to the plasma membrane [inference]

Golgi to plasma membrane transport [inference]

Golgi to plasma membrane protein transport

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to Golgi apparatus

establishment of protein localization [inference]

protein transport [inference]

Golgi to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

protein localization to cell periphery [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

Golgi to plasma membrane protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of receptor recycling

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

positive regulation of macroautophagy [inference]

positive regulation of xenophagy

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

positive regulation of macroautophagy [inference]

positive regulation of xenophagy

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

positive regulation of macroautophagy [inference]

positive regulation of xenophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy

positive regulation of macroautophagy [inference]

positive regulation of xenophagy

regulation of macroautophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of xenophagy

regulation of xenophagy [inference]

positive regulation of xenophagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

positive regulation of macroautophagy [inference]

positive regulation of xenophagy

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

positive regulation of macroautophagy [inference]

positive regulation of xenophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy

positive regulation of macroautophagy [inference]

positive regulation of xenophagy

regulation of macroautophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of xenophagy

regulation of xenophagy [inference]

positive regulation of xenophagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

positive regulation of macroautophagy [inference]

positive regulation of xenophagy

regulation of macromolecule metabolic process [inference]

regulation of receptor recycling [inference]

negative regulation of receptor recycling

negative regulation of macromolecule metabolic process [inference]

negative regulation of receptor recycling

regulation of signaling [inference]

regulation of receptor recycling [inference]

negative regulation of receptor recycling

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction

negative regulation of canonical NF-kappaB signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of signaling [inference]

negative regulation of receptor recycling

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

positive regulation of macroautophagy [inference]

positive regulation of xenophagy

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

positive regulation of macroautophagy [inference]

positive regulation of xenophagy

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

positive regulation of macroautophagy [inference]

positive regulation of xenophagy

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of xenophagy

positive regulation of response to external stimulus [inference]

positive regulation of xenophagy

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of receptor recycling

negative regulation of signaling [inference]

negative regulation of receptor recycling

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of xenophagy [inference]

positive regulation of xenophagy

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction

negative regulation of canonical NF-kappaB signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of xenophagy

regulation of xenophagy [inference]

positive regulation of xenophagy

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of xenophagy

positive regulation of response to external stimulus [inference]

positive regulation of xenophagy

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of xenophagy

regulation of cellular process [inference]

signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction

negative regulation of canonical NF-kappaB signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

positive regulation of macroautophagy [inference]

positive regulation of xenophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy

positive regulation of macroautophagy [inference]

positive regulation of xenophagy

regulation of macroautophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of xenophagy

regulation of xenophagy [inference]

positive regulation of xenophagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

positive regulation of macroautophagy [inference]

positive regulation of xenophagy

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

positive regulation of macroautophagy [inference]

positive regulation of xenophagy

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

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GO Term	Evidence Code	PMID
Golgi apparatus	IBA IDA	15837803 27534431
nucleoplasm	TAS
trans-Golgi network	IDA	20174559
Golgi membrane	TAS
recycling endosome membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

recycling endosome membrane

bounding membrane of organelle [inference]

Golgi membrane

endosome membrane [inference]

recycling endosome membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

vacuole [inference]

autophagosome

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

vacuole [inference]

autophagosome

Golgi apparatus

perinuclear region of cytoplasm

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GO Term	Evidence Code	PMID
protein binding	IPI	15837803 16189514 17500595 17646400 18307994 19805065 20174559 20195357 20388642 21516116 21617041 21903422 21988832 22854040 23275563 23414517 23956131 24136289 24705354 25026213 25416956 25803835 25910212 26871637 27086836 29892012 30561431 31515488 32296183 32707033 32814053 33961781 34524948
metal ion binding	IEA
protein-macromolecule adaptor activity	IPI	25803835
K63-linked polyubiquitin modification-dependent protein binding	IBA
identical protein binding	IPI	23414517 24983867 25416956 25910212 26871637 32296183

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding

modification-dependent protein binding [inference]

polyubiquitin modification-dependent protein binding

K63-linked polyubiquitin modification-dependent protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

nf-kappa-b essential modulator

Functional Category

I: Lipid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
K63-linked polyubiquitin modification-dependent protein binding
metal ion binding
regulation of canonical NF-kappaB signal transduction

Displaying **all 3** entries
InterPro
NEMO, Zinc finger
NF-kappa-B essential modulator NEMO, CC2-LZ domain
NF-kappa-B essential modulator NEMO, N-terminal

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0060203	amyotrophic lateral sclerosis type 12	Alliance of Genome Resources
DOID:0081294	neuronal intranuclear inclusion disease	Alliance of Genome Resources
DOID:1067	open-angle glaucoma	Alliance of Genome Resources
DOID:1070	primary open angle glaucoma	Alliance of Genome Resources
DOID:12858	Huntington's disease	Alliance of Genome Resources
DOID:13544	low tension glaucoma	Alliance of Genome Resources
DOID:13641	exfoliation syndrome	Alliance of Genome Resources
DOID:13948	bladder neck obstruction	Alliance of Genome Resources
DOID:14330	Parkinson's disease	Alliance of Genome Resources
DOID:1686	glaucoma	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	37967		FB:FBgn0041205
Mus musculus	71648		MGI:1918898	MOUSE31783
Rattus norvegicus	246294		RGD:628886	RATNO12093
Danio rerio	336159		ZFIN:ZDB-GENE-030131-8103	DANRE34386
Sus scrofa	397011			PIGXX00655
Canis lupus familiaris	478003			CANLF06560
Xenopus laevis	496250		Xenbase:XB-GENE-943661
Bos taurus	534150			BOVIN04424
Macaca mulatta	574252			MACMU46058
Pan troglodytes	736417	9598_0:002dc9		PANTR00172

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements