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poly (ADP-ribose) polymerase family, member 2

Summary

Gene Symbol

Parp2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

11546

PubChem

11546

Alliance of Genome Resources

MGI:1341112

Annotation

Keyword

3D-structure
ADP-ribosylation
Acetylation
Allosteric enzyme
Chromosome
DNA repair
DNA-binding
Glycosyltransferase
NAD
Nucleotidyltransferase
Nucleus
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
O88554	ADP-ribosyltransferase diphtheria toxin-like 2 DNA ADP-ribosyltransferase PARP2 NAD(+) ADP-ribosyltransferase 2 Poly[ADP-ribose] synthase 2 Protein poly-ADP-ribosyltransferase PARP2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
DNA repair	ISO
DNA repair	TAS	12065591
base-excision repair	IMP	11948190
double-strand break repair	IBA
cellular response to DNA damage stimulus	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

DNA modification [inference]

DNA ADP-ribosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

DNA modification [inference]

DNA ADP-ribosylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

DNA modification [inference]

DNA ADP-ribosylation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

DNA modification [inference]

DNA ADP-ribosylation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

DNA modification [inference]

DNA ADP-ribosylation

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

macromolecule modification [inference]

DNA modification [inference]

DNA ADP-ribosylation

protein modification process [inference]

post-translational protein modification [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

DNA modification [inference]

DNA ADP-ribosylation

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

DNA modification [inference]

DNA ADP-ribosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

extrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process [inference]

hippocampal neuron apoptotic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

DNA modification [inference]

DNA ADP-ribosylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

DNA modification [inference]

DNA ADP-ribosylation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

DNA modification [inference]

DNA ADP-ribosylation

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

DNA repair-dependent chromatin remodeling

reproductive process [inference]

developmental process involved in reproduction [inference]

decidualization

developmental process [inference]

developmental process involved in reproduction [inference]

decidualization

anatomical structure development [inference]

tissue development [inference]

decidualization

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to oxygen-glucose deprivation

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to oxygen-glucose deprivation

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

biological regulation [inference]

regulation of biological process [inference]

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of developmental growth [inference]

regulation of organ growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of biological process [inference]

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of cellular process [inference]

positive regulation of cell growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of multicellular organismal process [inference]

positive regulation of muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of response to stimulus [inference]

regulation of muscle adaptation [inference]

regulation of cardiac muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of striated muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of developmental growth [inference]

regulation of organ growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of multicellular organismal development [inference]

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

extrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of striated muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of cellular process [inference]

positive regulation of cell growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of striated muscle cell differentiation [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle hypertrophy [inference]

regulation of cardiac muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of muscle adaptation [inference]

regulation of cardiac muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of organ growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of multicellular organismal process [inference]

positive regulation of muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of multicellular organismal development [inference]

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cell growth involved in cardiac muscle cell development

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GO Term	Evidence Code	PMID
nucleus	ISO
nucleus	IDA	12065591
nucleoplasm	ISO
nucleoplasm	IDA	15615785
nucleolus	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

nucleolus

site of DNA damage

Displaying entries **16 - 20** of 25 in total

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GO Term	Evidence Code	PMID
NAD+-protein-serine ADP-ribosyltransferase activity	ISS
NAD+-protein-serine ADP-ribosyltransferase activity	ISO
NAD+- protein-aspartate ADP-ribosyltransferase activity	ISS
NAD+- protein-aspartate ADP-ribosyltransferase activity	ISO
NAD+-protein-glutamate ADP-ribosyltransferase activity	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

pentosyltransferase activity [inference]

NAD+-protein ADP-ribosyltransferase activity

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity

catalytic activity, acting on a protein [inference]

NAD+-protein ADP-ribosyltransferase activity

binding [inference]

protein binding

modification-dependent protein binding [inference]

ADP-D-ribose modification-dependent protein binding [inference]

poly-ADP-D-ribose modification-dependent protein binding

protein-containing complex binding [inference]

chromatin binding

nucleosome binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

damaged DNA binding

carbohydrate derivative binding [inference]

poly-ADP-D-ribose binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

poly(ADP-ribose) polymerase

Functional Category

L: Replication, recombination and repair
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
NAD+ ADP-ribosyltransferase activity
NAD+-protein ADP-ribosyltransferase activity
double-strand break repair
nucleotidyltransferase activity
transferase activity

Displaying **all 5** entries
InterPro
Poly(ADP-ribose) polymerase, catalytic domain
Poly(ADP-ribose) polymerase, regulatory domain superfamily
Poly(ADP-ribose) polymerase, regulatory domain
WGR domain superfamily
WGR domain

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	10038	Xenbase:XB-GENE-1001702	HUMAN17857
Xenopus tropicalis	11546	Xenbase:XB-GENE-1001702
Rattus norvegicus	290027		RATNO09330
Pan troglodytes	465197		PANTR08190
Canis lupus familiaris	475392		CANLF04137
Macaca mulatta	701955		MACMU40305
Xenopus tropicalis	3565967	Xenbase:XB-GENE-1001702
Danio rerio	100007906		DANRE28225
Monodelphis domestica	100029480		MONDO03191
Equus caballus	100072572		HORSE17821

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OrthoDB (Group)

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Acknowledgements