GlyCosmos Portal

Submissions

G protein-coupled bile acid receptor 1

Summary

Gene Symbol

GPBAR1

Organism

Homo sapiens (human)

External Links

NCBI Gene

151306

PubChem

151306

Alliance of Genome Resources

HGNC:19680

Annotation

Keyword

3D-structure
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8TDU6	G-protein coupled receptor GPCR19 Membrane-type receptor for bile acids hBG37

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
regulation of bicellular tight junction assembly	IEA
cell surface bile acid receptor signaling pathway	IDA	12419312 12524422
cellular response to bile acid	IDA	12419312 12524422
G protein-coupled receptor signaling pathway	IBA
positive regulation of ERK1 and ERK2 cascade	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cell surface bile acid receptor signaling pathway

G protein-coupled receptor signaling pathway

bile acid signaling pathway [inference]

cell surface bile acid receptor signaling pathway

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to bile acid

cellular response to organic cyclic compound [inference]

cellular response to bile acid

cellular response to oxygen-containing compound [inference]

cellular response to bile acid

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to organic cyclic compound [inference]

cellular response to organic cyclic compound [inference]

cellular response to bile acid

response to bile acid [inference]

cellular response to bile acid

response to lipid [inference]

cellular response to lipid [inference]

cellular response to bile acid

response to bile acid [inference]

cellular response to bile acid

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to bile acid

cellular response to organic cyclic compound [inference]

cellular response to bile acid

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to bile acid

cellular response to organic cyclic compound [inference]

cellular response to bile acid

cellular response to oxygen-containing compound [inference]

cellular response to bile acid

response to oxygen-containing compound [inference]

cellular response to oxygen-containing compound [inference]

cellular response to bile acid

response to bile acid [inference]

cellular response to bile acid

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to bile acid

cellular response to organic cyclic compound [inference]

cellular response to bile acid

cellular response to oxygen-containing compound [inference]

cellular response to bile acid

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of cholangiocyte proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cell surface bile acid receptor signaling pathway

G protein-coupled receptor signaling pathway

bile acid signaling pathway [inference]

cell surface bile acid receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of cholangiocyte proliferation

regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of cholangiocyte proliferation

regulation of cholangiocyte proliferation [inference]

positive regulation of cholangiocyte proliferation

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of bicellular tight junction assembly

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of cholangiocyte proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of cellular component organization [inference]

regulation of cell junction assembly [inference]

regulation of bicellular tight junction assembly

Displaying **all 3** entries
GO Term	Evidence Code	PMID
receptor complex	IDA	12419312 12524422
plasma membrane	IBA IDA TAS	12419312 12524422
cytoplasm	IDA	12524422

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	31978385
G protein-coupled bile acid receptor activity	IBA IDA NAS	12419312 12524422

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled bile acid receptor activity

bile acid receptor activity [inference]

G protein-coupled bile acid receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

G-protein coupled bile acid receptor 1

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
G protein-coupled bile acid receptor activity

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0080322	polycystic kidney disease	Alliance of Genome Resources
DOID:0080547	metabolic dysfunction-associated steatohepatitis	Alliance of Genome Resources
DOID:0110861	autosomal recessive polycystic kidney disease	Alliance of Genome Resources
DOID:898	autosomal dominant polycystic kidney disease	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 64 in total

« First

‹ Prev

1

2

3

4

5

6

7

Next ›

Last »
Species	Gene ID	Orthologous MAtrix
Capra hircus	102175999	CAPHI20359
Latimeria chalumnae	102347752	LATCH04735
Myotis lucifugus	102418921	MYOLU01007
Astyanax mexicanus	103021352	ASTMX16733
Chlorocebus sabaeus	103217859	CHLSB01607
Nannospalax galili	103727710	NANGA00439
Macaca nemestrina	105481207	MACNE17810
Mandrillus leucophaeus	105528031	MANLE05158
Cercocebus atys	105587072	CERAT22428
Dipodomys ordii	106002542	DIPOR00466