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G protein-coupled bile acid receptor 1

Summary

Gene Symbol

GPBAR1

Organism

Homo sapiens (human)

External Links

NCBI Gene

151306

PubChem

151306

Alliance of Genome Resources

HGNC:19680

Annotation

Keyword

3D-structure
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8TDU6	G-protein coupled receptor GPCR19 Membrane-type receptor for bile acids hBG37

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

1

2

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GO Term	Evidence Code	PMID
regulation of bicellular tight junction assembly	IEA
cell surface bile acid receptor signaling pathway	IDA	12419312 12524422
cellular response to bile acid	IDA	12419312 12524422
G protein-coupled receptor signaling pathway	IBA
positive regulation of ERK1 and ERK2 cascade	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cell surface bile acid receptor signaling pathway

G protein-coupled receptor signaling pathway

bile acid signaling pathway [inference]

cell surface bile acid receptor signaling pathway

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to bile acid

cellular response to organic cyclic compound [inference]

cellular response to bile acid

cellular response to oxygen-containing compound [inference]

cellular response to bile acid

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to organic cyclic compound [inference]

cellular response to organic cyclic compound [inference]

cellular response to bile acid

response to bile acid [inference]

cellular response to bile acid

response to lipid [inference]

cellular response to lipid [inference]

cellular response to bile acid

response to bile acid [inference]

cellular response to bile acid

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to bile acid

cellular response to organic cyclic compound [inference]

cellular response to bile acid

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to bile acid

cellular response to organic cyclic compound [inference]

cellular response to bile acid

cellular response to oxygen-containing compound [inference]

cellular response to bile acid

response to oxygen-containing compound [inference]

cellular response to oxygen-containing compound [inference]

cellular response to bile acid

response to bile acid [inference]

cellular response to bile acid

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to bile acid

cellular response to organic cyclic compound [inference]

cellular response to bile acid

cellular response to oxygen-containing compound [inference]

cellular response to bile acid

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of cholangiocyte proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cell surface bile acid receptor signaling pathway

G protein-coupled receptor signaling pathway

bile acid signaling pathway [inference]

cell surface bile acid receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of cholangiocyte proliferation

regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of cholangiocyte proliferation

regulation of cholangiocyte proliferation [inference]

positive regulation of cholangiocyte proliferation

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of bicellular tight junction assembly

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of cholangiocyte proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of cellular component organization [inference]

regulation of cell junction assembly [inference]

regulation of bicellular tight junction assembly

Displaying **all 3** entries
GO Term	Evidence Code	PMID
receptor complex	IDA	12419312 12524422
plasma membrane	IBA IDA TAS	12419312 12524422
cytoplasm	IDA	12524422

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	31978385
G protein-coupled bile acid receptor activity	IBA IDA NAS	12419312 12524422

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled bile acid receptor activity

bile acid receptor activity [inference]

G protein-coupled bile acid receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

G-protein coupled bile acid receptor 1

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
G protein-coupled bile acid receptor activity

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0080322	polycystic kidney disease	Alliance of Genome Resources
DOID:0080547	metabolic dysfunction-associated steatohepatitis	Alliance of Genome Resources
DOID:0110861	autosomal recessive polycystic kidney disease	Alliance of Genome Resources
DOID:898	autosomal dominant polycystic kidney disease	Alliance of Genome Resources