GlyCosmos Portal

Submissions

cytochrome P450 family 2 subfamily B member 6

Summary

Gene Symbol

CYP2B6

Aliases

CPB6
CYPIIB6

Organism

Homo sapiens (human)

External Links

NCBI Gene

1555

HGNC

2615

KEGG Gene ID

hsa:1555

PubChem

1555

Alliance of Genome Resources

HGNC:2615

Annotation

Keyword

3D-structure
Alternative splicing
Heme
Lipid metabolism
Membrane
Microsome
Monooxygenase
NADP
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P20813	1,4-cineole 2-exo-monooxygenase CYPIIB6 Cytochrome P450 IIB1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
epoxygenase P450 pathway	IBA
xenobiotic catabolic process	IDA	19029318
cellular ketone metabolic process	IDA	19651758
steroid metabolic process	IMP	18356043
xenobiotic metabolic process	IBA IDA IMP TAS	18356043 19651758 20061448

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

xenobiotic catabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

xenobiotic metabolic process

xenobiotic catabolic process

cellular ketone metabolic process

cellular catabolic process [inference]

xenobiotic catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

cellular ketone metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

lipid metabolic process [inference]

steroid metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

cellular ketone metabolic process

olefinic compound metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

organic cyclic compound metabolic process [inference]

steroid metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

xenobiotic metabolic process

xenobiotic catabolic process

cellular ketone metabolic process

cellular catabolic process [inference]

xenobiotic catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

Displaying **all 3** entries
GO Term	Evidence Code	PMID
intracellular membrane-bounded organelle	IBA
cytoplasm	IBA
endoplasmic reticulum membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying entry **11 - 11** of 11 in total

« First

‹ Prev

1

2

3
GO Term	Evidence Code	PMID
testosterone 16-alpha-hydroxylase activity	IDA	21289075

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity

arachidonic acid monooxygenase activity [inference]

arachidonic acid epoxygenase activity

steroid hydroxylase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

anandamide epoxidase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

testosterone 16-alpha-hydroxylase activity

arachidonic acid monooxygenase activity [inference]

arachidonic acid epoxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

anandamide epoxidase activity [inference]

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000197408

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K17709

Name

cytochrome P450 family 2 subfamily B6 [EC:1.14.14.-]

References

2573390

Disease

Disease Ontology

Displaying entries **421 - 426** of **426** in total

« First

‹ Prev

…

39

40

41

42

43
DO ID	Disease Name	Source
DOID:9854	lingual-facial-buccal dyskinesia	DisGeNET
DOID:9952	acute lymphoblastic leukemia	DisGeNET
DOID:9953	acute biphenotypic leukemia	DisGeNET
DOID:9970	obesity	DisGeNET Alliance of Genome Resources
DOID:9974	drug dependence	Alliance of Genome Resources
DOID:9976	heroin dependence	DisGeNET Alliance of Genome Resources

PubChem Disease

MedGen Diseases

Efavirenz response

OMIM Phenotypes

EFAVIRENZ, POOR METABOLISM OF

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000449
Gene Name: cytochrome P450, family 2, subfamily B, polypeptide 6

Ortholog

Displaying entries **1 - 10** of 98 in total

1

2

3

4

5

…

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	178695	WB:WBGene00016697
Caenorhabditis elegans	178704	WB:WBGene00018413
Caenorhabditis elegans	178803	WB:WBGene00019472
Caenorhabditis elegans	179148	WB:WBGene00015709
Caenorhabditis elegans	181850	WB:WBGene00015043
Caenorhabditis elegans	181851	WB:WBGene00015044
Caenorhabditis elegans	181852	WB:WBGene00015045
Caenorhabditis elegans	182176	WB:WBGene00015399
Caenorhabditis elegans	182177	WB:WBGene00015400
Caenorhabditis elegans	182888	WB:WBGene00016092

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements