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Peroxidasin homolog pxn-2

Summary

Gene Symbol

pxn-2

Organism

Caenorhabditis elegans

External Links

NCBI Gene

181288

PubChem

181288

Alliance of Genome Resources

WB:WBGene00004257

Annotation

Keyword

Basement membrane
Disulfide bond
Glycoprotein
Heme
Leucine-rich repeat
Peroxidase
Reference proteome
Repeat
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
G5EG78

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
muscle attachment	IMP	20876652
cellular oxidant detoxification	IEA
embryonic body morphogenesis	IMP	20876652
negative regulation of axon regeneration	IMP	20876652
axon guidance	IMP	20876652

GO Hierarchy

biological process

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

extracellular structure organization [inference]

extracellular matrix organization [inference]

basement membrane organization

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

basement membrane organization

cellular detoxification [inference]

cellular oxidant detoxification

multicellular organismal process [inference]

muscle attachment

developmental process [inference]

anatomical structure morphogenesis [inference]

body morphogenesis [inference]

embryonic body morphogenesis

embryonic morphogenesis [inference]

embryonic body morphogenesis

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of axon regeneration

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration

negative regulation of response to wounding [inference]

negative regulation of axon regeneration

negative regulation of developmental process [inference]

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of axon regeneration

regulation of axon regeneration [inference]

negative regulation of axon regeneration

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of axon regeneration

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration

negative regulation of response to wounding [inference]

negative regulation of axon regeneration

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of neuron projection regeneration [inference]

regulation of axon regeneration [inference]

negative regulation of axon regeneration

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration

regulation of response to wounding [inference]

regulation of axon regeneration [inference]

negative regulation of axon regeneration

negative regulation of response to wounding [inference]

negative regulation of axon regeneration

regulation of developmental process [inference]

negative regulation of developmental process [inference]

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration

regulation of neuron projection regeneration [inference]

regulation of axon regeneration [inference]

negative regulation of axon regeneration

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration

regulation of cellular process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

negative regulation of neuron projection development [inference]

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration

regulation of neuron projection regeneration [inference]

regulation of axon regeneration [inference]

negative regulation of axon regeneration

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration

regulation of extracellular matrix organization [inference]

regulation of basement membrane organization

regulation of cellular response to stress [inference]

regulation of neuron projection regeneration [inference]

regulation of axon regeneration [inference]

negative regulation of axon regeneration

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

Displaying **all 3** entries
GO Term	Evidence Code	PMID
basement membrane	IDA IEA	20876652 25475546
extracellular region	IEA
extracellular space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix [inference]

basement membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
lactoperoxidase activity	IEA
metal ion binding	IEA
peroxidase activity	IBA IEA
heme binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity

lactoperoxidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

antioxidant activity [inference]

peroxidase activity

lactoperoxidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

peroxidase

Functional Category

M: Cell wall/membrane/envelope biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
cellular oxidant detoxification
heme binding
metal ion binding
response to oxidative stress

Displaying **all 3** entries
InterPro
Haem peroxidase domain superfamily, animal type
Haem peroxidase superfamily
Haem peroxidase, animal-type

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
cytoplasm	PMID:20876652
neuron projection	PMID:16049479
basement membrane	PMID:20876652

Disease

Disease Ontology

Displaying entries **21 - 23** of 23 in total

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DO ID	Disease Name	Source
DOID:874	bacterial pneumonia	Alliance of Genome Resources
DOID:9362	status asthmaticus	Alliance of Genome Resources
DOID:9415	allergic asthma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 22 in total

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Species	Gene ID	Alliance of Genome Resources
Homo sapiens	4025	HGNC:6678
Homo sapiens	4353	HGNC:7218
Homo sapiens	7837	HGNC:14966
Homo sapiens	8288	HGNC:3423
Mus musculus	13861	MGI:107569
Mus musculus	17523	MGI:97137
Drosophila melanogaster	38326	FB:FBgn0011828
Mus musculus	69675	MGI:1916925
Mus musculus	76113	MGI:1923363
Homo sapiens	137902	HGNC:26359