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cadherin EGF LAG seven-pass G-type receptor 3

Summary

Gene Symbol

CELSR3

Organism

Homo sapiens (human)

External Links

NCBI Gene

1951

PubChem

1951

Alliance of Genome Resources

HGNC:3230

Annotation

Keyword

Alternative splicing
Calcium
Cell membrane
Developmental protein
Disulfide bond
EGF-like domain
G-protein coupled receptor
Glycoprotein
Hydroxylation
Laminin EGF-like domain
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NYQ7	Cadherin family member 11 Epidermal growth factor-like protein 1 Flamingo homolog 1 Multiple epidermal growth factor-like domains protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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2

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GO Term	Evidence Code	PMID
cell-cell adhesion	IBA
serotonergic neuron axon guidance	ISS
dopaminergic neuron axon guidance	ISS
homophilic cell adhesion via plasma membrane adhesion molecules	IEA
Wnt signaling pathway, planar cell polarity pathway	NAS	24431302

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

homophilic cell adhesion via plasma membrane adhesion molecules

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

non-canonical Wnt signaling pathway [inference]

Wnt signaling pathway, planar cell polarity pathway

G protein-coupled receptor signaling pathway

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

non-canonical Wnt signaling pathway [inference]

Wnt signaling pathway, planar cell polarity pathway

G protein-coupled receptor signaling pathway

Displaying **all 2** entries
GO Term	Evidence Code	PMID
membrane	TAS	15203201
plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	17474147
calcium ion binding	IEA
G protein-coupled receptor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cadherin EGF LAG seven-pass G-type receptor 3

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis

Displaying **all 2** entries
Gene Ontology
calcium ion binding
cell surface receptor signaling pathway

Displaying 1 entry
InterPro
GPCR, family 2-like, 7TM

Ortholog

Displaying entries **41 - 50** of 66 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Callithrix jacchus	103788239		CALJA12622
Pongo abelii	103890185	9601_0:000fd6	PONAB26203
Saimiri boliviensis boliviensis	104651102		SAIBB10742
Rhinopithecus roxellana	104667738		RHIRO14055
Macaca nemestrina	105480415		MACNE06961
Mandrillus leucophaeus	105540377		MANLE07333
Cercocebus atys	105573665		CERAT32295
Aotus nancymaae	105727668		AOTNA35649
Propithecus coquereli	105805055		PROCO00226
Salmo salar	106566780		SALSA32135