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MIRAGE
epidermal growth factor receptor
Summary
- Gene Symbol
-
- EGFR
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Cell membrane
- Developmental protein
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Endoplasmic reticulum
- Endosome
- Glycoprotein
- Golgi apparatus
- Host cell receptor for virus entry
- Host-virus interaction
- Hydroxylation
- Isopeptide bond
- Methylation
- Nucleus
- Palmitate
- Phosphoprotein
- Proteomics identification
- Proto-oncogene
- Receptor
- Reference proteome
- Repeat
- Secreted
- Signal
- Transmembrane helix
- Tyrosine-protein kinase
- Ubl conjugation
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of cell population proliferation | ||
| positive regulation of cell population proliferation | ||
| insulin receptor signaling pathway | ||
| fibroblast growth factor receptor signaling pathway | ||
| regulation of cell communication |
|
GO Hierarchy
- insulin receptor signaling pathway
- fibroblast growth factor receptor signaling pathway
- brain-derived neurotrophic factor receptor signaling pathway
- collagen-activated tyrosine kinase receptor signaling pathway
- vascular endothelial growth factor signaling pathway
- Kit signaling pathway
- insulin-like growth factor receptor signaling pathway
- hepatocyte growth factor receptor signaling pathway
- ephrin receptor signaling pathway
- positive regulation of cell growth
- insulin receptor signaling pathway
- fibroblast growth factor receptor signaling pathway
- brain-derived neurotrophic factor receptor signaling pathway
- collagen-activated tyrosine kinase receptor signaling pathway
- vascular endothelial growth factor signaling pathway
- Kit signaling pathway
- insulin-like growth factor receptor signaling pathway
- hepatocyte growth factor receptor signaling pathway
- ephrin receptor signaling pathway
- positive regulation of cell growth
biological process
metabolic process [inference]
cellular process [inference]
signal transduction
cell surface receptor signaling pathway
enzyme-linked receptor protein signaling pathway [inference]
transmembrane receptor protein tyrosine kinase signaling pathway [inference]
cellular response to stimulus [inference]
response to stimulus [inference]
response to endogenous stimulus [inference]
response to chemical [inference]
cellular response to stimulus [inference]
localization [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of metabolic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of nitrogen compound metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
positive regulation of phosphorus metabolic process [inference]
regulation of phosphate metabolic process [inference]
regulation of phosphorylation [inference]
regulation of protein phosphorylation [inference]
positive regulation of phosphorylation
regulation of kinase activity [inference]
positive regulation of phosphate metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of nitrogen compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of protein modification process [inference]
regulation of protein phosphorylation [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of protein modification process [inference]
regulation of protein phosphorylation [inference]
regulation of primary metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of protein modification process [inference]
regulation of protein phosphorylation [inference]
regulation of signaling
regulation of localization [inference]
positive regulation of biological process [inference]
positive regulation of metabolic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of nitrogen compound metabolic process [inference]
positive regulation of cellular process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cell cycle [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
signal transduction
cell surface receptor signaling pathway
enzyme-linked receptor protein signaling pathway [inference]
transmembrane receptor protein tyrosine kinase signaling pathway [inference]
regulation of cell communication
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
positive regulation of phosphorus metabolic process [inference]
regulation of phosphate metabolic process [inference]
regulation of phosphorylation [inference]
regulation of protein phosphorylation [inference]
positive regulation of phosphorylation
regulation of kinase activity [inference]
positive regulation of phosphate metabolic process [inference]
regulation of cell population proliferation
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cell cycle [inference]
regulation of cell cycle [inference]
regulation of cellular localization [inference]
regulation of multicellular organismal process [inference]
regulation of molecular function [inference]
positive regulation of molecular function [inference]
regulation of catalytic activity [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| endoplasmic reticulum membrane | ||
| Golgi apparatus | ||
| cytosol | ||
| plasma membrane | ||
| plasma membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| virus receptor activity | ||
| chromatin binding | ||
| double-stranded DNA binding | ||
| MAP kinase kinase kinase activity | ||
| protein tyrosine kinase activity |
GO Hierarchy
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
molecular function
catalytic activity [inference]
transferase activity [inference]
transferase activity, transferring phosphorus-containing groups [inference]
kinase activity [inference]
protein kinase activity [inference]
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
transmembrane receptor protein kinase activity [inference]
transmembrane receptor protein tyrosine kinase activity
phosphotransferase activity, alcohol group as acceptor [inference]
protein kinase activity [inference]
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
transmembrane receptor protein kinase activity [inference]
transmembrane receptor protein tyrosine kinase activity
catalytic activity, acting on a protein [inference]
protein kinase activity [inference]
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
transmembrane receptor protein kinase activity [inference]
transmembrane receptor protein tyrosine kinase activity
binding [inference]
molecular transducer activity [inference]
signaling receptor activity [inference]
transmembrane signaling receptor activity
transmembrane receptor protein kinase activity [inference]
transmembrane receptor protein tyrosine kinase activity
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- tyrosine-protein kinase receptor
- Functional Category
-
- K: Transcription
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050589 | inflammatory bowel disease | |
| DOID:10283 | prostate cancer | |
| DOID:1324 | lung cancer | |
| DOID:1793 | pancreatic cancer | |
| DOID:2957 | pulmonary tuberculosis | |
| DOID:3459 | breast carcinoma | |
| DOID:3908 | lung non-small cell carcinoma | |
| DOID:3910 | lung adenocarcinoma | |
| DOID:4926 | bronchiolo-alveolar adenocarcinoma | |
| DOID:9256 | colorectal cancer |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 1956 | Xenbase:XB-GENE-6067152 | ||
| 2064 | FB:FBgn0003731 | ||
| 2065 | FB:FBgn0003731 | ||
| 2066 | FB:FBgn0003731 | ||
| 13649 | Xenbase:XB-GENE-6067152 | MOUSE07215 | |
| 13866 | FB:FBgn0003731 | ||
| 13867 | FB:FBgn0003731 | ||
| 13869 | FB:FBgn0003731 | ||
| 24329 | RATNO08169 | ||
| 29496 | FB:FBgn0003731 |
