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NEDD4 like E3 ubiquitin protein ligase

Summary

Gene Symbol

NEDD4L

Organism

Homo sapiens (human)

External Links

NCBI Gene

23327

PubChem

23327

Alliance of Genome Resources

HGNC:7728

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cytoplasm
Differentiation
Direct protein sequencing
Disease variant
Endosome
Golgi apparatus
Host-virus interaction
Phosphoprotein
Reference proteome
Repeat
Transferase
Ubl conjugation
Ubl conjugation pathway

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B7Z6K0
B7Z2P9
Q96PU5	HECT-type E3 ubiquitin transferase NED4L NEDD4.2 Nedd4-2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 34 in total

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GO Term	Evidence Code	PMID
regulation of membrane depolarization	IDA	15217910
ubiquitin-dependent protein catabolic process	IDA	17502380 21463633
ubiquitin-dependent protein catabolic process	IBA
protein monoubiquitination	IEA
neuromuscular junction development	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

protein K48-linked ubiquitination

protein monoubiquitination

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

catabolic process [inference]

cellular catabolic process [inference]

receptor catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

receptor catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

receptor catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

protein K48-linked ubiquitination

protein monoubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

receptor catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

protein K48-linked ubiquitination

protein monoubiquitination

receptor metabolic process [inference]

receptor catabolic process

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

protein K48-linked ubiquitination

protein monoubiquitination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

protein K48-linked ubiquitination

protein monoubiquitination

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

receptor catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

cellular metabolic process [inference]

cellular catabolic process [inference]

receptor catabolic process

cellular developmental process [inference]

cell differentiation

transmembrane transport [inference]

monoatomic ion transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development

cell junction organization [inference]

synapse organization [inference]

neuromuscular junction development

developmental process [inference]

cellular developmental process [inference]

cell differentiation

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic ion transmembrane transport

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

transmembrane transport [inference]

monoatomic ion transmembrane transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

regulation of potassium ion transmembrane transporter activity

negative regulation of potassium ion transmembrane transporter activity

regulation of sodium ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion transmembrane transporter activity

negative regulation of sodium ion transmembrane transport

regulation of ion transmembrane transport

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion transmembrane transporter activity

negative regulation of sodium ion transmembrane transport

regulation of monoatomic cation transmembrane transport [inference]

regulation of potassium ion transmembrane transport [inference]

regulation of potassium ion transmembrane transporter activity

negative regulation of potassium ion transmembrane transporter activity

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion transmembrane transporter activity

regulation of sodium ion transmembrane transport

negative regulation of sodium ion transmembrane transport

regulation of sodium ion import across plasma membrane [inference]

negative regulation of sodium ion import across plasma membrane

regulation of sodium ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion transmembrane transporter activity

negative regulation of sodium ion transmembrane transport

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of sodium ion transport [inference]

negative regulation of sodium ion transport [inference]

negative regulation of sodium ion transmembrane transport

regulation of sodium ion transmembrane transport

negative regulation of sodium ion transmembrane transport

regulation of sodium ion import across plasma membrane [inference]

negative regulation of sodium ion import across plasma membrane

regulation of sodium ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

regulation of potassium ion transport [inference]

negative regulation of potassium ion transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion transmembrane transporter activity

regulation of potassium ion transmembrane transport [inference]

regulation of potassium ion transmembrane transporter activity

negative regulation of potassium ion transmembrane transporter activity

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion transmembrane transporter activity

regulation of ion transmembrane transport

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion transmembrane transporter activity

negative regulation of sodium ion transmembrane transport

regulation of monoatomic cation transmembrane transport [inference]

regulation of potassium ion transmembrane transport [inference]

regulation of potassium ion transmembrane transporter activity

negative regulation of potassium ion transmembrane transporter activity

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion transmembrane transporter activity

regulation of sodium ion transmembrane transport

negative regulation of sodium ion transmembrane transport

regulation of sodium ion import across plasma membrane [inference]

negative regulation of sodium ion import across plasma membrane

regulation of sodium ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion transmembrane transporter activity

negative regulation of sodium ion transmembrane transport

negative regulation of monoatomic ion transport [inference]

negative regulation of sodium ion transport [inference]

negative regulation of sodium ion transmembrane transport

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion transmembrane transporter activity

negative regulation of sodium ion transmembrane transport

negative regulation of potassium ion transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion transmembrane transporter activity

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of caveolin-mediated endocytosis

negative regulation of transport [inference]

negative regulation of transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion transmembrane transporter activity

negative regulation of sodium ion transmembrane transport

negative regulation of monoatomic ion transport [inference]

negative regulation of sodium ion transport [inference]

negative regulation of sodium ion transmembrane transport

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion transmembrane transporter activity

negative regulation of sodium ion transmembrane transport

negative regulation of potassium ion transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion transmembrane transporter activity

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of caveolin-mediated endocytosis

regulation of caveolin-mediated endocytosis [inference]

positive regulation of caveolin-mediated endocytosis

regulation of cellular localization [inference]

regulation of protein localization [inference]

negative regulation of protein localization [inference]

negative regulation of protein localization to cell surface

regulation of protein localization to cell surface [inference]

negative regulation of protein localization to cell surface

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

regulation of dendrite extension [inference]

positive regulation of dendrite extension

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

regulation of developmental growth [inference]

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

regulation of dendrite extension [inference]

positive regulation of dendrite extension

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

positive regulation of cellular process [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of caveolin-mediated endocytosis

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of caveolin-mediated endocytosis

positive regulation of developmental process [inference]

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion transmembrane transporter activity

negative regulation of sodium ion transmembrane transport

negative regulation of protein localization [inference]

negative regulation of protein localization to cell surface

negative regulation of transport [inference]

negative regulation of transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion transmembrane transporter activity

negative regulation of sodium ion transmembrane transport

negative regulation of monoatomic ion transport [inference]

negative regulation of sodium ion transport [inference]

negative regulation of sodium ion transmembrane transport

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion transmembrane transporter activity

negative regulation of sodium ion transmembrane transport

negative regulation of potassium ion transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion transmembrane transporter activity

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of dendrite extension [inference]

positive regulation of dendrite extension

regulation of dendrite morphogenesis

regulation of developmental growth [inference]

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

regulation of dendrite extension [inference]

positive regulation of dendrite extension

regulation of dendrite development [inference]

regulation of dendrite morphogenesis

positive regulation of developmental process [inference]

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

regulation of cellular process [inference]

regulation of membrane depolarization

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

regulation of potassium ion transmembrane transporter activity

negative regulation of potassium ion transmembrane transporter activity

regulation of sodium ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion transmembrane transporter activity

negative regulation of sodium ion transmembrane transport

regulation of ion transmembrane transport

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion transmembrane transporter activity

negative regulation of sodium ion transmembrane transport

regulation of monoatomic cation transmembrane transport [inference]

regulation of potassium ion transmembrane transport [inference]

regulation of potassium ion transmembrane transporter activity

negative regulation of potassium ion transmembrane transporter activity

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion transmembrane transporter activity

regulation of sodium ion transmembrane transport

negative regulation of sodium ion transmembrane transport

regulation of sodium ion import across plasma membrane [inference]

negative regulation of sodium ion import across plasma membrane

regulation of sodium ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion transmembrane transporter activity

negative regulation of sodium ion transmembrane transport

positive regulation of cellular process [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of caveolin-mediated endocytosis

negative regulation of cellular process [inference]

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport

negative regulation of potassium ion transmembrane transporter activity

negative regulation of sodium ion transmembrane transport

negative regulation of protein localization [inference]

negative regulation of protein localization to cell surface

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

regulation of dendrite extension [inference]

positive regulation of dendrite extension

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of caveolin-mediated endocytosis

regulation of caveolin-mediated endocytosis [inference]

positive regulation of caveolin-mediated endocytosis

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of dendrite development [inference]

regulation of dendrite morphogenesis

regulation of synapse organization

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of caveolin-mediated endocytosis

regulation of cellular localization [inference]

regulation of protein localization [inference]

negative regulation of protein localization [inference]

negative regulation of protein localization to cell surface

regulation of protein localization to cell surface [inference]

negative regulation of protein localization to cell surface

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of caveolin-mediated endocytosis

regulation of caveolin-mediated endocytosis [inference]

positive regulation of caveolin-mediated endocytosis

regulation of membrane repolarization

regulation of biological quality [inference]

regulation of protein stability

regulation of membrane potential

action potential [inference]

cardiac muscle cell action potential [inference]

cardiac muscle cell action potential involved in contraction [inference]

ventricular cardiac muscle cell action potential

regulation of molecular function [inference]

regulation of transporter activity [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

regulation of potassium ion transmembrane transporter activity

negative regulation of potassium ion transmembrane transporter activity

regulation of sodium ion transmembrane transporter activity [inference]

negative regulation of sodium ion transmembrane transporter activity

negative regulation of transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of molecular function [inference]

negative regulation of transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

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GO Term	Evidence Code	PMID
nucleoplasm	TAS
cytoplasm	IBA
multivesicular body	IEA
Golgi apparatus	IEA
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	PMID
ubiquitin-protein transferase activity	NAS	11244092
ubiquitin-protein transferase activity	TAS
protein binding	IPI	11244092 15677482 18577513 19664597 19706893 20086093 20936779 22024150 22921829 23236378 23529131 23686771 23873930 25416956 26854353 27445338 28514442 31980649 32296183 33961781 34927784 35271311 36931259 38270169
potassium channel regulator activity	IDA	17289006
sodium channel regulator activity	IDA	11244092

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

catalytic activity, acting on a protein [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

binding [inference]

protein binding

transmembrane transporter binding

molecular function regulator activity [inference]

molecular function inhibitor activity [inference]

transporter inhibitor activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

transporter regulator activity [inference]

channel regulator activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

ion channel regulator activity [inference]

ion channel inhibitor activity [inference]

potassium channel regulator activity

potassium channel inhibitor activity

sodium channel regulator activity

sodium channel inhibitor activity

transporter inhibitor activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Ubiquitin-protein ligase E3

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
proteasome-mediated ubiquitin-dependent protein catabolic process
protein polyubiquitination

Displaying **all 2** entries
InterPro
HECT domain
HECT, E3 ligase catalytic domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050454	periventricular nodular heterotopia	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	4734	SGD:S000000927
Saccharomyces cerevisiae S288C	11060	SGD:S000000927
Saccharomyces cerevisiae S288C	17999	SGD:S000000927
Xenopus tropicalis	23327	Xenbase:XB-GENE-489248
Saccharomyces cerevisiae S288C	66894	SGD:S000000927
Mus musculus	83814		MOUSE23773
Rattus norvegicus	291553		RATNO14091
Pan troglodytes	455443		PANTR16357
Canis lupus familiaris	476189		CANLF00085
Bos taurus	510003		BOVIN19822

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements