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MIRAGE
brain-derived neurotrophic factor
Summary
- Gene Symbol
-
- Bdnf
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
-
- Cleavage on pair of basic residues
- Disulfide bond
- Glycoprotein
- Growth factor
- Reference proteome
- Secreted
- Signal
- Proteins
| UniProt | Protein Name |
|---|---|
| A6HP02 |
|
| A6HP04 |
|
| P23363 |
|
| A6HP01 |
|
| A0A0G2K624 |
|
| A0A0H2UI28 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of neuron projection development | ||
| behavioral fear response | ||
| positive regulation of peptidyl-serine phosphorylation | ||
| neuron differentiation | ||
| neuron projection extension |
GO Hierarchy
- response to activity
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
response to endogenous stimulus [inference]
response to chemical [inference]
cellular response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of signaling [inference]
signaling [inference]
regulation of growth [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of programmed cell death [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cellular component organization [inference]
regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| cytoplasmic vesicle | ||
| hippocampal mossy fiber to CA3 synapse | ||
| glutamatergic synapse | ||
| axon | ||
| synaptic vesicle |
| GO Term | Evidence Code | PMID |
|---|---|---|
| growth factor activity | ||
| neurotrophin TRKB receptor binding | ||
| nerve growth factor receptor binding |
OrthoDB (Group)
- Group level
- Rodentia
- Group Name
- Brain-derived neurotrophic factor
- Functional Category
-
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
| InterPro |
|---|
| Brain-derived neurotrophic factor |
| Cystine-knot cytokine |
| Nerve growth factor conserved site |
| Nerve growth factor-like |
| Nerve growth factor-related |
Alliance of Genome Resources
- Expression
| Location | References |
|---|---|
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050741 | alcohol dependence | |
| DOID:0050848 | obstructive sleep apnea | |
| DOID:0060001 | withdrawal disorder | |
| DOID:0060041 | autism spectrum disorder | |
| DOID:0060731 | congenital central hypoventilation syndrome | |
| DOID:0080855 | Parkinsonism | |
| DOID:10126 | keratoconus | |
| DOID:10652 | Alzheimer's disease | |
| DOID:1070 | primary open angle glaucoma | |
| DOID:10914 | amnestic disorder |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 627 | HGNC:1033 | HUMAN05100 | ||
| 12064 | 10090_1:0008db | MGI:88145 | MOUSE34601 | |
| 58118 | ZFIN:ZDB-GENE-000412-1 | DANRE39504 | ||
| 397495 | PIGXX17500 | |||
| 493690 | FELCA24057 | |||
| 503511 | PANTR02543 | |||
| 554233 | MONDO28037 | |||
| 617701 | BOVIN07322 | |||
| 701245 | MACMU09565 | |||
| 751584 | TAEGU25191 |
