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Guidelines

MIRAGE

leptin receptor

Summary

Gene Symbol

Lepr

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24536

PubChem

24536

Alliance of Genome Resources

RGD:3001

Annotation

Keyword

Alternative splicing
Cell membrane
Disease variant
Disulfide bond
Glycoprotein
Obesity
Phosphoprotein
Receptor
Reference proteome
Repeat
Secreted
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q62959	OB receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 73 in total

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GO Term	Evidence Code	PMID
angiogenesis	ISS
angiogenesis	ISO
angiogenesis	IMP	12393625
angiogenesis	IEA
ovulation from ovarian follicle	IEP	12959975

GO Hierarchy

biological process

reproduction [inference]

sexual reproduction

immune system process [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation

T cell activation [inference]

T cell differentiation

metabolic process [inference]

biosynthetic process [inference]

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

cellular metabolic process [inference]

generation of precursor metabolites and energy

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

glucan metabolic process [inference]

glycogen metabolic process

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

glucan metabolic process [inference]

glycogen metabolic process

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

macromolecule metabolic process [inference]

polysaccharide metabolic process [inference]

glucan metabolic process [inference]

glycogen metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation

T cell activation [inference]

T cell differentiation

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

leptin-mediated signaling pathway

receptor signaling pathway via STAT

cell population proliferation [inference]

glial cell proliferation

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis

cellular metabolic process [inference]

generation of precursor metabolites and energy

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to acetate

cellular response to lipid [inference]

cellular response to fatty acid [inference]

cellular response to butyrate

cellular response to nitrogen compound [inference]

cellular response to acetate

cellular response to oxygen-containing compound [inference]

cellular response to acetate

cellular response to fatty acid [inference]

cellular response to butyrate

cellular response to salt [inference]

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

ovulation cycle process [inference]

ovulation from ovarian follicle

multi-organism reproductive process [inference]

female pregnancy

multicellular organismal reproductive process [inference]

ovulation [inference]

ovulation from ovarian follicle

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation

T cell activation [inference]

T cell differentiation

behavior [inference]

feeding behavior [inference]

eating behavior

organ growth [inference]

bone growth

multi-multicellular organism process [inference]

female pregnancy

multicellular organismal-level homeostasis [inference]

energy homeostasis

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

animal organ development [inference]

gonad development [inference]

male gonad development

reproductive structure development [inference]

gonad development [inference]

male gonad development

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation

growth [inference]

developmental growth [inference]

organ growth [inference]

bone growth

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

energy homeostasis

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

rhythmic process [inference]

ovulation cycle process [inference]

ovulation from ovarian follicle

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to dexamethasone

response to chemical [inference]

response to nutrient

response to organic substance [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to dexamethasone

response to acetate [inference]

cellular response to acetate

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to dexamethasone

response to lipid

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to dexamethasone

response to fatty acid [inference]

cellular response to fatty acid [inference]

cellular response to butyrate

response to butyrate [inference]

cellular response to butyrate

cellular response to lipid [inference]

cellular response to fatty acid [inference]

cellular response to butyrate

cellular response to organic substance [inference]

cellular response to acetate

cellular response to lipid [inference]

cellular response to fatty acid [inference]

cellular response to butyrate

response to ketone [inference]

response to dexamethasone

response to nicotine

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to acetate

cellular response to lipid [inference]

cellular response to fatty acid [inference]

cellular response to butyrate

cellular response to nitrogen compound [inference]

cellular response to acetate

cellular response to oxygen-containing compound [inference]

cellular response to acetate

cellular response to fatty acid [inference]

cellular response to butyrate

cellular response to salt [inference]

response to nitrogen compound [inference]

response to acetate [inference]

cellular response to acetate

cellular response to nitrogen compound [inference]

cellular response to acetate

response to oxygen-containing compound [inference]

response to acetate [inference]

cellular response to acetate

response to fatty acid [inference]

cellular response to fatty acid [inference]

cellular response to butyrate

response to butyrate [inference]

cellular response to butyrate

response to ketone [inference]

response to dexamethasone

cellular response to oxygen-containing compound [inference]

cellular response to acetate

cellular response to fatty acid [inference]

cellular response to butyrate

response to salt [inference]

response to acetate [inference]

cellular response to acetate

cellular response to salt [inference]

response to butyrate [inference]

cellular response to butyrate

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to acetate

cellular response to lipid [inference]

cellular response to fatty acid [inference]

cellular response to butyrate

cellular response to nitrogen compound [inference]

cellular response to acetate

cellular response to oxygen-containing compound [inference]

cellular response to acetate

cellular response to fatty acid [inference]

cellular response to butyrate

cellular response to salt [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis

import into cell [inference]

endocytosis [inference]

phagocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

regulation of carbohydrate biosynthetic process [inference]

regulation of gluconeogenesis [inference]

negative regulation of gluconeogenesis

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

negative regulation of carbohydrate metabolic process [inference]

negative regulation of gluconeogenesis

negative regulation of small molecule metabolic process [inference]

negative regulation of gluconeogenesis

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

negative regulation of autophagy

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

negative regulation of autophagy

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of small molecule metabolic process [inference]

regulation of glucose metabolic process [inference]

regulation of gluconeogenesis [inference]

negative regulation of gluconeogenesis

negative regulation of small molecule metabolic process [inference]

negative regulation of gluconeogenesis

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of glucose metabolic process [inference]

regulation of gluconeogenesis [inference]

negative regulation of gluconeogenesis

regulation of carbohydrate biosynthetic process [inference]

regulation of gluconeogenesis [inference]

negative regulation of gluconeogenesis

negative regulation of carbohydrate metabolic process [inference]

negative regulation of gluconeogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of localization [inference]

regulation of transport

regulation of secretion [inference]

regulation of peptide secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide transport [inference]

regulation of peptide secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of circadian rhythm [inference]

negative regulation of circadian rhythm [inference]

negative regulation of locomotor rhythm

regulation of locomotor rhythm [inference]

negative regulation of locomotor rhythm

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

negative regulation of carbohydrate metabolic process [inference]

negative regulation of gluconeogenesis

negative regulation of small molecule metabolic process [inference]

negative regulation of gluconeogenesis

negative regulation of circadian rhythm [inference]

negative regulation of locomotor rhythm

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

negative regulation of multicellular organismal process [inference]

negative regulation of behavior [inference]

negative regulation of locomotor rhythm

negative regulation of feeding behavior [inference]

negative regulation of eating behavior

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

leptin-mediated signaling pathway

receptor signaling pathway via STAT

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

negative regulation of autophagy

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of multicellular organismal process [inference]

regulation of tissue remodeling [inference]

regulation of bone remodeling

regulation of behavior [inference]

negative regulation of behavior [inference]

negative regulation of locomotor rhythm

negative regulation of feeding behavior [inference]

negative regulation of eating behavior

regulation of feeding behavior

regulation of eating behavior [inference]

negative regulation of eating behavior

negative regulation of feeding behavior [inference]

negative regulation of eating behavior

regulation of locomotor rhythm [inference]

negative regulation of locomotor rhythm

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of behavior [inference]

negative regulation of locomotor rhythm

negative regulation of feeding behavior [inference]

negative regulation of eating behavior

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extracellular space	IDA	16037380
external side of plasma membrane	IBA
basolateral plasma membrane	IEA
receptor complex	ISO
receptor complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

extracellular space

membrane [inference]

plasma membrane region [inference]

basolateral plasma membrane

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
cytokine receptor activity	IBA
cytokine receptor activity	IEA
protein-hormone receptor activity	IDA	17023527 9070213
protein-hormone receptor activity	IMP	17023527
peptide hormone binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

amide binding [inference]

peptide binding [inference]

peptide hormone binding

hormone binding [inference]

peptide hormone binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity

leptin receptor activity

protein-hormone receptor activity

immune receptor activity [inference]

cytokine receptor activity

leptin receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

leptin receptor

Functional Category

C: Energy production and conversion
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
cytokine-mediated signaling pathway

Displaying **all 5** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin C2-set-like, ligand-binding
Immunoglobulin-like fold
Leptin receptor, immunoglobulin-like domain

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
extracellular space	PMID:16037380

Disease

Disease Ontology

Displaying entries **1 - 10** of 12 in total

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DO ID	Disease Name	Source
DOID:0050855	renal fibrosis	Alliance of Genome Resources
DOID:10603	glucose intolerance	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:2018	hyperinsulinism	Alliance of Genome Resources
DOID:4195	hyperglycemia	Alliance of Genome Resources
DOID:4989	pancreatitis	Alliance of Genome Resources
DOID:576	proteinuria	Alliance of Genome Resources
DOID:6000	congestive heart failure	Alliance of Genome Resources
DOID:784	chronic kidney disease	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 57 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Meleagris gallopavo	100125334		MELGA02504
Taeniopygia guttata	100229897		TAEGU29665
Oryctolagus cuniculus	100351924		RABIT03826
Callithrix jacchus	100408177		CALJA40387
Pongo abelii	100461924		PONAB19817
Ailuropoda melanoleuca	100470278		AILME08282
Nomascus leucogenys	100602850		NOMLE31149
Cavia porcellus	100725434		CAVPO01781
Cricetulus griseus	100756564		CRIGR17603
Sarcophilus harrisii	100914129		SARHA10730

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Last updated: April 7, 2025